The combination of chemotherapy can enhance the efficacy of immune checkpoint inhibitors (ICIs), but requires precise patient stratification and biomarker screening. Cytokines influence immunotherapy outcomes, and multiplex cytokine profiling aids in...
This study evaluates post-vaccination adverse events by analyzing a large dataset of patients with major autoimmune diseases, including Hashimoto's n=26,330; Rheumatoid Arthritis n=9,251; psoriasis n=5,589; Systemic Lupus Erythematosus n=4,208; Infla...
AIM: Parkinson's disease (PD) and progressive supranuclear palsy (PSP) present similar clinical symptoms, but their treatment options and clinical prognosis differ significantly. Therefore, we aimed to discriminate between PD and PSP based on multi-l...
Existing multiple instance learning (MIL) methods treat whole slide image (WSI) as collections of independent patches, neglecting these crucial spatial and morphological connections. This paper proposes K-Stage Transformer with multiple instance lear...
Ecotoxicology and environmental safety
Jul 22, 2025
BACKGROUND: Breast cancer (BRCA) is the most common malignancy in women worldwide. Selenium (Se), a crucial trace element, significantly impacts BRCA patient survival, although its roles in tumorigenesis, the tumor immune microenvironment (TIME), and...
BACKGROUND AND OBJECTIVES: Although disease-modifying therapies (DMTs) may suppress coronavirus disease 2019 (COVID-19) vaccine responses in people with multiple sclerosis (pwMS), limited data are available on the cumulative effect of additional boos...
Despite advancements in in vitro fertilization (IVF) over the past 30 years, its outcome effectiveness remains low (20-40%). This study introduces a microfluidic-based machine learning framework to improve predictive accuracy in oocyte quality assess...
With the rapid advancement of generative artificial intelligence (AI), its potential applications in higher education have attracted significant attention. This study investigated how 148 students from diverse engineering disciplines and regions acro...
BACKGROUND: Ambient fine particulate matter (PM) is a significant global public health concern. However, large-scale research has yet to explore the effects of long-term PM exposure on the pulmonary nodule characteristics.
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with heterogeneous symptomatology, making accurate diagnosis challenging. Traditional methods rely on subjective behavioral assessments, often overlooking subtle neural biomarke...
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