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A Machine Learning-Based Strategy Predicts Selective and Synergistic Drug Combinations for Relapsed Acute Myeloid Leukemia.

Cancer research
UNLABELLED: Combination therapies are one potential approach to improve the outcomes of patients with relapsed/refractory (R/R) disease. However, comprehensive testing in scarce primary patient material is hampered by the many drug combination possib...

A Transformer-Based Framework for Counterfactual Estimation of Antihypertensive Treatment Effect on COVID-19 Infection Risk - A Proof-of-Concept Study.

American journal of hypertension
BACKGROUND: Transformer-based neural networks excel in modelling high-dimensional, time-series data with complex dependencies. This proof-of-concept study applies a transformer-X-learner framework to estimate treatment effects using real-world data, ...

Machine learning-driven risk prediction and feature identification for major depressive disorder and its progression: an exploratory study based on five years of longitudinal data from the US national health survey.

Journal of affective disorders
BACKGROUND: Major depressive disorder (MDD) presents significant public health challenges due to its increasing prevalence and complex risk factors. This study systematically analyzed data from 2019 to 2023 to explore trends in MDD incidence, symptom...

Multimodal depression recognition and analysis: Facial expression and body posture changes via emotional stimuli.

Journal of affective disorders
BACKGROUND: Clinical studies have shown that facial expressions and body posture in depressed patients differ significantly from those of healthy individuals. Combining relevant behavioral features with artificial intelligence technology can effectiv...

EEG-based prediction of reaction time during sleep deprivation.

Sleep
Prolonged wakefulness is known to adversely affect basic cognitive abilities such as object recognition and decision-making. It affects the dynamics of neuronal networks in the brain and can even lead to hallucinations and epileptic seizures. In cogn...

Artificial intelligence or sleep experts: comparing polysomnographic sleep staging in children and adolescents.

Sleep
STUDY OBJECTIVES: The manual annotation of polysomnography (PSG) hypnograms is difficult and time-consuming. U-Sleep is an alternative, fast, and publicly available, automated sleep staging system evaluated in adult PSGs. In this study, we compare th...

Towards real time efficient and robust ECoG decoding for mobile brain-computer interface.

Journal of neural engineering
. Decoding locomotion-related brain activities from electrocorticographic (ECoG) signals is essential in brain-computer interfaces (BCIs). Most previous ECoG decoders are computationally demanding and sensitive to noises/outliers. Mobile and robust B...

Mid-level data fusion of pleural effusion SERS spectra and serum CEA levels using machine learning algorithms for precise lung cancer detection.

Nanoscale
Accurate identification of clinically malignant pleural effusions is critical for cancer diagnosis and subsequent treatment planning. Here, surface-enhanced Raman spectroscopy (SERS) data of pleural effusions and serum carcinoembryonic antigen (CEA) ...

Clinical Application of Large Language Models for Intervention Plan Development in Speech-Language Pathology.

American journal of speech-language pathology
PURPOSE: This study investigates the speech and language intervention plan outputs generated by six different artificial intelligence (AI) tools powered by large language models (LLMs), currently available for clinical writing in the field of speech-...