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Combining machine learning and single-cell sequencing to identify key immune genes in sepsis.

Scientific reports
This research aimed to identify novel indicators for sepsis by analyzing RNA sequencing data from peripheral blood samples obtained from sepsis patients (n = 23) and healthy controls (n = 10). 5148 differentially expressed genes were identified using...

Glycosylation profiling of triple-negative breast cancer: clinical and immune correlations and identification of LMAN1L as a biomarker and therapeutic target.

Frontiers in immunology
INTRODUCTION: Breast cancer (BC) is the most prevalent malignant tumor in women, with triple-negative breast cancer (TNBC) showing the poorest prognosis among all subtypes. Glycosylation is increasingly recognized as a critical biomarker in the tumor...

Developing and validating a machine learning model to predict multidrug-resistant -related septic shock.

Frontiers in immunology
BACKGROUND: Multidrug-resistant Klebsiella pneumoniae (MDR-KP) infections pose a significant global healthcare challenge, particularly due to the high mortality risk associated with septic shock. This study aimed to develop and validate a machine lea...

The influence of factors related to public health campaigns on vaccination behavior among population of Wuxi region, China.

Frontiers in public health
BACKGROUND: Public health campaigns are essential for promoting vaccination behavior, but factors such as socioeconomic status, geographical location, campaign quality, and service accessibility influence vaccine uptake. In the Wuxi region of China, ...

Evaluating the effect of noise reduction strategies in CT perfusion imaging for predicting infarct core with deep learning.

The neuroradiology journal
This study evaluates the efficacy of deep learning models in identifying infarct tissue on computed tomography perfusion (CTP) scans from patients with acute ischemic stroke due to large vessel occlusion, specifically addressing the potential influen...

Multiple constraint network classification reveals functional brain networks distinguishing 0-back and 2-back task.

Canadian journal of experimental psychology = Revue canadienne de psychologie experimentale
Working memory is associated with general intelligence and is crucial for performing complex cognitive tasks. Neuroimaging investigations have recognized that working memory is supported by a distribution of activity in regions across the entire brai...

Noninvasive identification of HER2 status by integrating multiparametric MRI-based radiomics model with the vesical imaging-reporting and data system (VI-RADS) score in bladder urothelial carcinoma.

Abdominal radiology (New York)
PURPOSE: HER2 expression is crucial for the application of HER2-targeted antibody-drug conjugates. This study aims to construct a predictive model by integrating multiparametric magnetic resonance imaging (mpMRI) based multimodal radiomics and the Ve...

Risk prediction for elderly cognitive impairment by radiomic and morphological quantification analysis based on a cerebral MRA imaging cohort.

European radiology
OBJECTIVE: To establish morphological and radiomic models for early prediction of cognitive impairment associated with cerebrovascular disease (CI-CVD) in an elderly cohort based on cerebral magnetic resonance angiography (MRA).

Machine Learning Algorithms in Controlled Donation After Circulatory Death Under Normothermic Regional Perfusion: A Graft Survival Prediction Model.

Transplantation
BACKGROUND: Several scores have been developed to stratify the risk of graft loss in controlled donation after circulatory death (cDCD). However, their performance is unsatisfactory in the Spanish population, where most cDCD livers are recovered usin...