AIMC Topic: Gene Expression Regulation, Neoplastic

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A method of gene expression data transfer from cell lines to cancer patients for machine-learning prediction of drug efficiency.

Cell cycle (Georgetown, Tex.) Jan 17, 2018
Personalized medicine implies that distinct treatment methods are prescribed to individual patients according several features that may be obtained from, e.g., gene expression profile. The majority of machine learning methods suffer from the deficien...
Humans ROC Curve Gene Expression Regulation, Neoplastic Area Under Curve Machine Learning Kidney Neoplasms Databases, Factual Precision Medicine Antineoplastic Agents
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A Risk Stratification Model for Lung Cancer Based on Gene Coexpression Network and Deep Learning.

BioMed research international Jan 16, 2018
Risk stratification model for lung cancer with gene expression profile is of great interest. Instead of previous models based on individual prognostic genes, we aimed to develop a novel system-level risk stratification model for lung adenocarcinoma b...
Lung Neoplasms Gene Expression Regulation, Neoplastic Adenocarcinoma Models, Biological Humans Machine Learning Risk Assessment Gene Regulatory Networks Adenocarcinoma of Lung
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Support vector machine classifier for prediction of the metastasis of colorectal cancer.

International journal of molecular medicine Jan 2, 2018
Colorectal cancer (CRC) is one of the most common cancers and a major cause of mortality. The present study aimed to identify potential biomarkers for CRC metastasis and uncover the mechanisms underlying the etiology of the disease. The five datasets...
Gene Expression Regulation, Neoplastic Colorectal Neoplasms Humans Neoplasm Metastasis Gene Expression Profiling Support Vector Machine Reproducibility of Results Cell Line, Tumor Databases, Genetic Protein Interaction Maps Quality Control
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Tiresias: Context-sensitive Approach to Decipher the Presence and Strength of MicroRNA Regulatory Interactions.

Theranostics Jan 1, 2018
MicroRNAs (miRNAs) are short non-coding RNAs that regulate expression of target messenger RNAs (mRNAs) post-transcriptionally. Understanding the precise regulatory role of miRNAs is of great interest since miRNAs have been shown to play an important ...
Gene Expression Regulation, Neoplastic MicroRNAs Bayes Theorem Animals Humans Computational Biology Neural Networks, Computer RNA, Messenger Machine Learning
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HCV nonstructural protein 4 is associated with aggressiveness features of breast cancer.

Breast cancer (Tokyo, Japan) Dec 28, 2017
BACKGROUND: Hepatitis C virus (HCV) has the lymphotropic feature that is supposed to be the reason of related extrahepatic manifestation. HCV viral oncoproteins may participate in the regulation of some gene expression that has been implicated in tum...
Viral Nonstructural Proteins Mucin-1 Hepatitis C Antibodies Fibronectins Hepacivirus Hepatitis C Incidence Gene Expression Regulation, Neoplastic Enzyme-Linked Immunosorbent Assay Carcinogenesis Humans Adult Egypt Breast Neoplasms Female Neoplasm Staging Middle Aged Aged Neoplasm Grading Disease Progression
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Overexpression of EMMPRIN is associated with lymph node metastasis and advanced stage of non-small cell lung cancer: a retrospective study.

BMC pulmonary medicine Dec 28, 2017
BACKGROUND: Previous studies show that overexpression of EMMPRIN involved in the malignant biological behavior of tumors. This investigation was to disclose the expression status of EMMPRIN in non-small cell lung cancer (NSCLC) and its clinical value...
Humans Retrospective Studies Female Risk Factors Neoplasm Staging Biomarkers, Tumor Immunohistochemistry Gene Expression Regulation, Neoplastic Male Up-Regulation Lymph Nodes Basigin Carcinoma, Non-Small-Cell Lung Middle Aged Lymphatic Metastasis ROC Curve Lung Neoplasms
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Identification of the functional alteration signatures across different cancer types with support vector machine and feature analysis.

Biochimica et biophysica acta. Molecular basis of disease Dec 19, 2017
Cancers are regarded as malignant proliferations of tumor cells present in many tissues and organs, which can severely curtail the quality of human life. The potential of using plasma DNA for cancer detection has been widely recognized, leading to th...
DNA, Neoplasm Gene Ontology Genes, Neoplasm Humans Neoplasms Gene Expression Regulation, Neoplastic Support Vector Machine
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The Interplay Between Epithelial-Mesenchymal Transition (EMT) and the Thyroid Hormones-αvβ3 Axis in Ovarian Cancer.

Hormones & cancer Dec 19, 2017
Ovarian cancer is a highly metastatic disease. The metastatic potential is enhanced by epithelial to mesenchymal transition (EMT) in which αvβ3 integrin plays a role. Thyroid hormones (L-thyroxine, T4, and 3,5,3'-triiodo-L-thyronine, T3) bind this in...
Zinc Finger E-box-Binding Homeobox 1 Triiodothyronine beta Catenin Integrin alphaVbeta3 Humans Ovarian Neoplasms Snail Family Transcription Factors Female Zonula Occludens-1 Protein Cell Line, Tumor Cadherins Epithelial-Mesenchymal Transition Gene Expression Regulation, Neoplastic Thyroid Hormones Thyroxine Signal Transduction Vimentin
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Hybrid Method Based on Information Gain and Support Vector Machine for Gene Selection in Cancer Classification.

Genomics, proteomics & bioinformatics Dec 12, 2017
It remains a great challenge to achieve sufficient cancer classification accuracy with the entire set of genes, due to the high dimensions, small sample size, and big noise of gene expression data. We thus proposed a hybrid gene selection method, Inf...
Gene Expression Regulation, Neoplastic Support Vector Machine Databases, Genetic Genes, Neoplasm Humans Neoplasms Computational Biology
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Construction of a 26‑feature gene support vector machine classifier for smoking and non‑smoking lung adenocarcinoma sample classification.

Molecular medicine reports Dec 7, 2017
The present study aimed to identify the feature genes associated with smoking in lung adenocarcinoma (LAC) samples and explore the underlying mechanism. Three gene expression datasets of LAC samples were downloaded from the Gene Expression Omnibus da...
Gene Expression Regulation, Neoplastic Adenocarcinoma Support Vector Machine Databases, Genetic Cluster Analysis Smoking Adenocarcinoma of Lung Humans Gene Expression Profiling Protein Interaction Maps Lung Neoplasms
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