AIMC Topic: Gene Regulatory Networks

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Machine learning combined with multi-omics to identify immune-related LncRNA signature as biomarkers for predicting breast cancer prognosis.

Scientific reports Jul 4, 2025
This study developed an immune-related long non-coding RNAs (lncRNAs)-based prognostic signature by integrating multi-omics data and machine learning algorithms to predict survival and therapeutic responses in breast cancer patients. Utilizing transc...
Machine Learning Prognosis Female Breast Neoplasms Humans Gene Regulatory Networks Multiomics Gene Expression Regulation, Neoplastic RNA, Long Noncoding Biomarkers, Tumor Gene Expression Profiling Transcriptome Immune Checkpoint Inhibitors
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Cohesive data analysis for the identification of prognostic hub genes and significant pathways associated with HER2 + and TN breast cancer types.

Scientific reports Jul 2, 2025
Breast cancer is the most prevalent and lethal form of cancer being the utmost common medical concern of women. Breast cancer etiology implicates numerous cellular protein receptors such as estrogen receptors (ER), progesterone receptors (PR), and hu...
Humans Prognosis Female Breast Neoplasms Gene Regulatory Networks Biomarkers, Tumor Gene Expression Regulation, Neoplastic Receptor, ErbB-2 Gene Expression Profiling Triple Negative Breast Neoplasms Transcriptome Support Vector Machine
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Integrating bioinformatics and machine learning to investigate the mechanisms by which three major respiratory infectious diseases exacerbate heart failure.

Scientific reports Jul 2, 2025
Heart failure (HF) is a severe cardiovascular disease often worsened by respiratory infections like influenza, COVID-19, and community-acquired pneumonia (CAP). This study aims to uncover the molecular commonalities among these respiratory diseases a...
Humans Machine Learning COVID-19 Influenza, Human SARS-CoV-2 Heart Failure ROC Curve Community-Acquired Infections Gene Regulatory Networks Computational Biology
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Unveiling diagnostic biomarkers and therapeutic targets in lung adenocarcinoma using bioinformatics and experimental validation.

Scientific reports Jul 2, 2025
Lung adenocarcinoma (LUAD) is a major challenge in oncology due to its complex molecular structure and generally poor prognosis. The aim of this study was to find diagnostic markers and therapeutic targets for LUAD by integrating differential gene ex...
Prognosis Biomarkers, Tumor Gene Expression Profiling Transcriptome Gene Regulatory Networks Lung Neoplasms Computational Biology Gene Expression Regulation, Neoplastic Humans Machine Learning Databases, Genetic Adenocarcinoma of Lung
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Identification of exosome-related genes in NSCLC via integrated bioinformatics and machine learning analysis.

Scientific reports Jul 2, 2025
Exosomes are crucial in the development of non-small cell lung cancer (NSCLC), yet exosome-associated genes in NSCLC remain insufficiently explored. The present study identified 59 exosome-associated differentially expressed genes (EA-DEGs) from the ...
Gene Regulatory Networks Lung Neoplasms Machine Learning Computational Biology Prognosis Humans Carcinoma, Non-Small-Cell Lung Biomarkers, Tumor Gene Expression Regulation, Neoplastic Databases, Genetic Gene Expression Profiling Exosomes
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Integrating machine learning and bioinformatics approaches to identify novel diagnostic gene biomarkers for diabetic mice.

Scientific reports Jul 2, 2025
Diabetes is a complex metabolic disorder, and its pathogenesis involves the interplay of genetic, environmental factors, and lifestyle choices. With the rising prevalence and increasing associated chronic complications, identifying and understanding ...
Gene Regulatory Networks Mice Computational Biology Databases, Genetic Animals Gene Expression Profiling Protein Interaction Maps HMGB1 Protein Diabetes Mellitus, Experimental Sirtuin 1 Gene Ontology Machine Learning Biomarkers
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Lactylation associated biomarkers and immune infiltration in aortic dissection.

Scientific reports Jul 1, 2025
Protein lactylation, a novel post-translational modification (PTM), has emerged as a critical factor in disease processes related to glycolysis and immune responses. However, its role in aortic dissection (AD) has yet to be thoroughly investigated. T...
Gene Regulatory Networks Animals Aortic Dissection Humans Mice Phosphoglycerate Kinase Male Machine Learning Computational Biology Gene Expression Profiling Biomarkers Protein Processing, Post-Translational Transcriptome
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Identification of potential pathogenic genes associated with the comorbidity of rheumatoid arthritis and renal fibrosis using bioinformatics and machine learning.

Scientific reports Jul 1, 2025
This study aimed to identify the potential pathogenic genes associated with the comorbidity of rheumatoid arthritis (RA) and renal fibrosis (RF). Transcriptomic data related to RA and RF were retrieved from the GEO database. Differential expression g...
Gene Regulatory Networks Databases, Genetic Arthritis, Rheumatoid Comorbidity MicroRNAs Computational Biology Humans Gene Expression Profiling Machine Learning Kidney Diseases Kidney Transcriptome Fibrosis
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Machine learning unveils hypoxia-immune gene hub for clinical stratification of thyroid-associated ophthalmopathy.

Scientific reports Jul 1, 2025
Thyroid-associated ophthalmopathy (TAO) is an autoimmune disorder affecting the orbit, potentially resulting in blindness. This study focused on the role of hypoxia in its pathogenesis through integrative bioinformatics and experimental validation. F...
Hypoxia Gene Expression Regulation Gene Regulatory Networks Humans Computational Biology Machine Learning Fibroblasts Graves Ophthalmopathy Protein Interaction Maps
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Decoding the diagnostic biomarkers of mitochondrial dysfunction related gene variants in pediatric T cell acute lymphoblastic leukemia.

Scientific reports Jul 1, 2025
Mitochondrial dysfunction is crucial in the pathogenesis and drug resistance of pediatric T-cell acute lymphoblastic leukemia (T-ALL), a malignant hematological disorder with unrestrained proliferation of immature T-cells. Therefore, the primary obje...
Gene Regulatory Networks RNA, Messenger MicroRNAs Mitochondria Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Gene Expression Regulation, Leukemic Gene Expression Profiling Adolescent Child, Preschool Humans Child Female Biomarkers, Tumor Male
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