AIMC Topic: Hep G2 Cells

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Design and synthesis of new phthalazine-based derivatives as potential EGFR inhibitors for the treatment of hepatocellular carcinoma.

Bioorganic chemistry Dec 31, 2018
Searching for new leads in the battle of cancer will never ends, we herein disclose the design and synthesis of new phthalazine derivatives and their in vitro and in vivo testing for their antiproliferative activity. Phthalazine was selected as a pri...
Doxorubicin Carcinoma, Hepatocellular ErbB Receptors Humans Phthalazines Molecular Docking Simulation Cell Proliferation Protein Kinase Inhibitors Antineoplastic Agents Hep G2 Cells Liver Neoplasms Drug Screening Assays, Antitumor Cisplatin
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Putative identification of components in Zengye Decoction and their effects on glucose consumption and lipogenesis in insulin-induced insulin-resistant HepG2 cells.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Dec 12, 2017
Zengye Decoction (ZYD) is a well-known traditional medicine in China used for treating diseases associated with "Yin deficiency" such as diabetes. However, little information is available on its components, pharmacological effects and underlying mech...
Humans Insulin Glycolysis Glucose Insulin Resistance Lipogenesis Hep G2 Cells Drugs, Chinese Herbal AMP-Activated Protein Kinases
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The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury.

Expert review of gastroenterology & hepatology Oct 9, 2017
Drug-induced liver injury (DILI) is challenging for drug development, clinical practice and regulation. The Liver Toxicity Knowledge Base (LTKB) provides essential data for DILI study. Areas covered: The LTKB provided various types of data that can b...
Animals Risk Assessment Drug Discovery Severity of Illness Index Incidence Humans Databases, Factual Pharmaceutical Preparations Knowledge Bases Toxicology Chemical and Drug Induced Liver Injury Toxicogenetics Hep G2 Cells Liver Structure-Activity Relationship Molecular Structure
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Exploration of Wedelia chinensis leaf-assisted silver nanoparticles for antioxidant, antibacterial and in vitro cytotoxic applications.

Journal of food and drug analysis Aug 31, 2017
Green synthetic route of silver nanoparticles (AgNPs) has already been proved to be an advantageous over other physico-chemical approaches due to its simplicity, cost effectiveness, ecofriendly and nontoxicity. In this finding, aqueous Wedelia chinen...
Surface Plasmon Resonance Wedelia Hep G2 Cells Cell Survival Humans Metal Nanoparticles Anti-Bacterial Agents Silver Bacteria Antioxidants Plant Extracts
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Imputation for transcription factor binding predictions based on deep learning.

PLoS computational biology Feb 24, 2017
Understanding the cell-specific binding patterns of transcription factors (TFs) is fundamental to studying gene regulatory networks in biological systems, for which ChIP-seq not only provides valuable data but is also considered as the gold standard....
Protein Interaction Mapping Chromatin Immunoprecipitation Machine Learning Reproducibility of Results Sensitivity and Specificity Protein Binding Transcription Factors Hep G2 Cells Humans High-Throughput Nucleotide Sequencing Neural Networks, Computer K562 Cells Binding Sites
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Graphene oxide as a nanocarrier for controlled release and targeted delivery of an anticancer active agent, chlorogenic acid.

Materials science & engineering. C, Materials for biological applications Dec 5, 2016
We have synthesized graphene oxide using improved Hummer's method in order to explore the potential use of the resulting graphene oxide as a nanocarrier for an active anticancer agent, chlorogenic acid (CA). The synthesized graphene oxide and chlorog...
Thermogravimetry X-Ray Diffraction Delayed-Action Preparations Hydrogen Bonding Microscopy, Electron, Transmission Cell Survival A549 Cells Nanocomposites Humans Oxides Drug Liberation Antineoplastic Agents Hydrogen-Ion Concentration HeLa Cells Spectrum Analysis, Raman Graphite Spectroscopy, Fourier Transform Infrared Chlorogenic Acid Hep G2 Cells
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Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction.

Nucleic acids research Nov 29, 2016
The binding and contribution of transcription factors (TF) to cell specific gene expression is often deduced from open-chromatin measurements to avoid costly TF ChIP-seq assays. Thus, it is important to develop computational methods for accurate TF b...
Humans Machine Learning Algorithms Cell Line, Tumor Protein Binding DNA CD4-Positive T-Lymphocytes Hepatocytes Gene Expression Regulation Organ Specificity Transcription Factors Hep G2 Cells Cell Line Principal Component Analysis Chromatin K562 Cells Chromatin Assembly and Disassembly Histones Human Embryonic Stem Cells Binding Sites Primary Cell Culture
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PHENOLIC PROFILE OF L. GROWING IN EGYPT AND ITS CYTOTOXIC AND ANTIVIRAL ACTIVITIES.

African journal of traditional, complementary, and alternative medicines : AJTCAM Sep 29, 2016
BACKGROUND: L (Asteraceae), is one of the most attractive plants growing wildly in Sinai, and is not well investigated for its phytochemical constituents. This study represents the first in-depth characterization of the phenolic profile of the aeria...
Humans HeLa Cells Antiviral Agents Antineoplastic Agents, Phytogenic HCT116 Cells Plant Extracts Phenols Plant Components, Aerial MCF-7 Cells Hep G2 Cells Centaurea Egypt Tandem Mass Spectrometry
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PHYTOCHEMISTRY, CYTOTOXICITY AND APOPTOSIS STUDIES OF B-SITOSTEROL-3--GLUCOSIDE AND Β -AMYRIN FROM .

African journal of traditional, complementary, and alternative medicines : AJTCAM Jul 3, 2016
BACKGROUND: is used traditionally in many countries for the treatment of cancer and benign prostate hyperplasia.
Humans Glucosides Plant Extracts HEK293 Cells Hep G2 Cells Apoptosis Oleanolic Acid Cell Survival Sitosterols Plant Leaves Prunus africana Caco-2 Cells
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Application of artificial neural network to investigate the effects of 5-fluorouracil on ribonucleotides and deoxyribonucleotides in HepG2 cells.

Scientific reports Nov 18, 2015
Endogenous ribonucleotides and deoxyribonucleotides are essential metabolites that play important roles in a broad range of key cellular functions. Their intracellular levels could also reflect the action of nucleoside analogues. We investigated the ...
Guanine Nucleotides Ribonucleotides Thymine Nucleotides Uracil Nucleotides Chromatography, Liquid Metabolic Networks and Pathways Models, Biological Fluorouracil Humans Tandem Mass Spectrometry Neural Networks, Computer Inhibitory Concentration 50 Hep G2 Cells Adenine Nucleotides Cell Survival Cytosine Nucleotides Deoxyribonucleotides
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