AIMC Topic: HIV Infections
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Intelligent Network DisRuption Analysis (INDRA): A targeted strategy for efficient interruption of hepatitis C transmissions.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
May 31, 2018
Hepatitis C virus (HCV) infection is a global public health problem. The implementation of public health interventions (PHI) to control HCV infection could effectively interrupt HCV transmission. PHI targeting high-risk populations, e.g., people who ...
Spatial extreme learning machines: An application on prediction of disease counts.
Statistical methods in medical research
Apr 9, 2018
Extreme learning machines have gained a lot of attention by the machine learning community because of its interesting properties and computational advantages. With the increase in collection of information nowadays, many sources of data have missing ...
Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires.
Frontiers in immunology
Feb 21, 2018
The adaptive immune system recognizes antigens an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in...
Depression and alcohol use disorder at antiretroviral therapy initiation led to disengagement from care in South Africa.
PloS one
Dec 27, 2017
We sought to assess mental health at the time of antiretroviral therapy (ART) initiation and subsequent retention in care over a six-month follow-up period. A total of 136 people living with HIV in South Africa were administered surveys measuring dem...
Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats.
Journal of neurovirology
Dec 19, 2017
Binge drinking affects the onset and progression of human immunodeficiency virus (HIV)-associated neurological disorders. The HIV-1 transgenic (HIV-1Tg) rat was created with a gag- and pol-deleted HIV-1 viral genome to mimic HIV-infected patients rec...
Evaluation of a Urine-Based Rapid Molecular Diagnostic Test with Potential to Be Used at Point-of-Care for Pulmonary Tuberculosis: Cape Town Cohort.
The Journal of molecular diagnostics : JMD
Dec 18, 2017
Tuberculosis (TB) diagnosis among sputum-scarce patients is time consuming. Thus, a nonsputum diagnostic alternative is urgently needed. The Mycobacterium tuberculosis-specific transrenal (Tr) DNA from urine is a potential target for TB diagnostics. ...
Multivariate Analysis
Male
Point-of-Care Systems
Tuberculosis, Pulmonary
Middle Aged
Mycobacterium tuberculosis
HIV Infections
Diagnostic Tests, Routine
Humans
Young Adult
Polymerase Chain Reaction
Universities
Biomarkers
Adult
Cohort Studies
Female
Sputum
Sensitivity and Specificity
Molecular Diagnostic Techniques
Risk Factors
South Africa
Cross-Sectional Studies
DNA, Bacterial
Aged
Microscopy
Aged, 80 and over
Logistic Models
UPLC-MS/MS method for the simultaneous quantification of sofosbuvir, sofosbuvir metabolite (GS-331007) and daclatasvir in plasma of HIV/HCV co-infected patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 12, 2017
Direct-acting antiviral agents (DAAs) represent the major advance in hepatitis C virus (HCV) infection treatment leading to extremely high eradication rates in HCV mono- and HIV/HCV co-infected patients. In this scenery, availability of Therapeutic D...
What Is the most Important for Elite Control: Genetic Background of Patient, Genetic Background of Partner, both or neither? Description of Complete Natural History within a Couple of MSM.
EBioMedicine
Dec 7, 2017
BACKGROUND: We describe a homosexual man who strongly controlled HIV-1 for ten years despite lack of protective genetic background.
A survey of machine learning applications in HIV clinical research and care.
Computers in biology and medicine
Nov 9, 2017
A wealth of genetic, demographic, clinical and biomarker data is collected from routine clinical care of HIV patients and exists in the form of medical records available among the medical care and research communities. Machine learning (ML) methods h...
Improving fold resistance prediction of HIV-1 against protease and reverse transcriptase inhibitors using artificial neural networks.
BMC bioinformatics
Aug 15, 2017
BACKGROUND: Drug resistance in HIV treatment is still a worldwide problem. Predicting resistance to antiretrovirals (ARVs) before starting any treatment is important. Prediction accuracy is essential, as low-accuracy predictions increase the risk of ...
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