AIMC Topic: HIV Infections

Clear Filters Showing 121 to 130 of 232 articles

Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy.

HIV research & clinical practice Feb 4, 2020
Chronic HIV is associated with increased inflammation and tissue fibrosis despite suppressive antiretroviral therapy (ART). Monocytes and macrophages have been implicated in the pathogenesis of fibrosis, facilitated by chemokine receptor interaction...
Cohort Studies Monocytes Inflammation Male Imidazoles Humans CCR5 Receptor Antagonists Middle Aged Macrophages Receptors, CCR2 HIV Infections Biomarkers Sulfoxides Anti-HIV Agents Female
View on PubMed DOI

Characterization of low level viraemia in HIV-infected patients receiving boosted protease inhibitor-based antiretroviral regimens.

HIV research & clinical practice Jan 30, 2020
To understand the pathogenesis of low level viraemia (LLV) in HIV-infected patients on boosted protease inhibitors (PI/b), we enrolled 34 subjects with a median HIV-RNA 79 copies/mL and followed them for 15 months. Samples for next generation sequenc...
gag Gene Products, Human Immunodeficiency Virus HIV Infections Viral Load Mutation Viremia Humans Female United Kingdom Anti-Retroviral Agents Adult Drug Resistance, Multiple, Viral Male Antiretroviral Therapy, Highly Active HIV Protease Middle Aged HIV-1 HIV Protease Inhibitors High-Throughput Nucleotide Sequencing
View on PubMed DOI

A comparison of machine learning techniques for classification of HIV patients with antiretroviral therapy-induced mitochondrial toxicity from those without mitochondrial toxicity.

BMC medical research methodology Nov 27, 2019
BACKGROUND: Antiretroviral therapy (ART) has significantly reduced HIV-related morbidity and mortality. However, therapeutic benefit of ART is often limited by delayed drug-associated toxicity. Nucleoside reverse transcriptase inhibitors (NRTIs) are ...
Humans HIV Infections Anti-Retroviral Agents Deoxyribonucleotides Ribonucleotides Dideoxynucleotides Machine Learning Algorithms Biomarkers Case-Control Studies
View on PubMed DOI

Accurate Prediction for Antibody Resistance of Clinical HIV-1 Isolates.

Scientific reports Oct 11, 2019
Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have promising utility in prevention and treatment of HIV-1 infection, and several are currently undergoing clinical trials. Due to the high sequence diversity an...
Immunoglobulin Idiotypes Neutralization Tests env Gene Products, Human Immunodeficiency Virus HIV Antibodies Epitope Mapping Humans Binding Sites, Antibody Computer Simulation Broadly Neutralizing Antibodies HIV Infections Prognosis Deep Learning HIV-1 Data Accuracy Drug Resistance, Viral
View on PubMed DOI

Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints.

Journal of chemical information and modeling Aug 19, 2019
Discovery and optimization of small molecule inhibitors as therapeutic drugs have immensely benefited from rational structure-based drug design. With recent advances in high-resolution structure determination, computational power, and machine learnin...
Humans Machine Learning Molecular Docking Simulation HIV-1 Drug Design Ligands Drug Discovery HIV Protease HIV Infections HIV Protease Inhibitors Protein Binding
View on PubMed DOI

Targeting HIV/HCV Coinfection Using a Machine Learning-Based Multiple Quantitative Structure-Activity Relationships (Multiple QSAR) Method.

International journal of molecular sciences Jul 22, 2019
Human immunodeficiency virus type-1 and hepatitis C virus (HIV/HCV) coinfection occurs when a patient is simultaneously infected with both human immunodeficiency virus type-1 (HIV-1) and hepatitis C virus (HCV), which is common today in certain popul...
Molecular Structure Bayes Theorem Hepacivirus Hepatitis C Anti-HIV Agents Antiviral Agents Protein Binding Models, Molecular Polypharmacology HIV-1 Molecular Conformation Quantitative Structure-Activity Relationship Databases, Pharmaceutical Humans Machine Learning Algorithms Drug Discovery HIV Infections
View on PubMed DOI

Incorporating causal factors into reinforcement learning for dynamic treatment regimes in HIV.

BMC medical informatics and decision making Apr 9, 2019
BACKGROUND: Reinforcement learning (RL) provides a promising technique to solve complex sequential decision making problems in health care domains. However, existing studies simply apply naive RL algorithms in discovering optimal treatment strategies...
HIV Infections Reinforcement, Psychology Clinical Protocols Humans Machine Learning Algorithms Clinical Decision-Making
View on PubMed DOI

Novel Machine Learning Identifies Brain Patterns Distinguishing Diagnostic Membership of Human Immunodeficiency Virus, Alcoholism, and Their Comorbidity of Individuals.

Biological psychiatry. Cognitive neuroscience and neuroimaging Mar 1, 2019
The incidence of alcohol use disorder (AUD) in human immunodeficiency virus (HIV) infection is twice that of the rest of the population. This study documents complex radiologically identified, neuroanatomical effects of AUD+HIV comorbidity by identif...
Humans HIV Infections Machine Learning Male Brain Magnetic Resonance Imaging Female Middle Aged Image Interpretation, Computer-Assisted Adult Comorbidity Alcoholism
View on PubMed DOI

Multiple Machine Learning Comparisons of HIV Cell-based and Reverse Transcriptase Data Sets.

Molecular pharmaceutics Feb 26, 2019
The human immunodeficiency virus (HIV) causes over a million deaths every year and has a huge economic impact in many countries. The first class of drugs approved were nucleoside reverse transcriptase inhibitors. A newer generation of reverse transcr...
HIV Reverse Transcriptase Humans Decision Trees Neural Networks, Computer Bayes Theorem Drug Discovery Machine Learning HIV HIV Infections Databases, Factual Reverse Transcriptase Inhibitors Anti-HIV Agents Support Vector Machine
View on PubMed DOI

Automated diagnosis of HIV-associated neurocognitive disorders using large-scale Granger causality analysis of resting-state functional MRI.

Computers in biology and medicine Jan 15, 2019
HIV-associated neurocognitive disorders (HAND) represent an important source of neurologic complications in individuals with HIV. The dynamic, often subclinical, course of HAND has rendered diagnosis, which currently depends on neuropsychometric (NP)...
HIV Infections Support Vector Machine Magnetic Resonance Imaging Neurocognitive Disorders Adult Male Middle Aged Diagnosis, Computer-Assisted Humans Brain Female
View on PubMed DOI
Popular Topics
Recent Journals