Identifying selective sweeps in populations that have complex demographic histories remains a difficult problem in population genetics. We previously introduced a supervised machine learning approach, S/HIC, for finding both hard and soft selective s...
Chronic fatigue syndrome (CFS) is a disorder associated with fatigue, pain, and structural/functional abnormalities seen during magnetic resonance brain imaging (MRI). Therefore, we evaluated the performance of structural MRI (sMRI) abnormalities in ...
BACKGROUND: Gene-expression companion diagnostic tests, such as the Oncotype DX test, assess the risk of early stage Estrogen receptor (ER) positive (+) breast cancers, and guide clinicians in the decision of whether or not to use chemotherapy. Howev...
IEEE/ACM transactions on computational biology and bioinformatics
May 29, 2018
Likely drug candidates which are identified in traditional pre-clinical drug screens often fail in patient trials, increasing the societal burden of drug discovery. A major contributing factor to this phenomenon is the failure of traditional in vitro...
International journal of computer assisted radiology and surgery
May 29, 2018
PURPOSE: Understanding decisions of deep learning techniques is important. Especially in the medical field, the reasons for a decision in a classification task are as crucial as the pure classification results. In this article, we propose a new appro...
International journal of computer assisted radiology and surgery
May 29, 2018
PURPOSE: Detection of eye diseases and their treatment is a key to reduce blindness, which impacts human daily needs like driving, reading, writing, etc. Several methods based on image processing have been used to monitor the presence of macular dise...
Computational intelligence and neuroscience
May 27, 2018
Multispectral palmprint recognition system (MPRS) is an essential technology for effective human identification and verification tasks. To improve the accuracy and performance of MPRS, a novel approach based on autoencoder (AE) and regularized extrem...
Neuroimaging studies have been steadily explored in Bipolar Disorder (BD) in the last decades. Neuroanatomical changes tend to be more pronounced in patients with repeated episodes. Although the role of such changes in cognition and memory is well es...
IEEE transactions on pattern analysis and machine intelligence
May 24, 2018
We present a method combining affinity prediction with region agglomeration, which improves significantly upon the state of the art of neuron segmentation from electron microscopy (EM) in accuracy and scalability. Our method consists of a 3D U-Net, t...
Computational and mathematical methods in medicine
May 24, 2018
The clinical assistant diagnosis has a high requirement for the visual effect of medical images. However, the low frequency subband coefficients obtained by the NSCT decomposition are not sparse, which is not conducive to maintaining the details of t...
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