AIMC Topic: Interleukin-6
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Influences of Edaravone on Necroptosis-Related Proteins and Oxidative Stress in Rats with Lower Extremity Ischemia/Reperfusion Injury.
Cellular and molecular biology (Noisy-le-Grand, France)
Jul 31, 2022
The study aimed to investigate the influences of edaravone on necroptosis-related proteins and oxidative stress in rats with lower extremity ischemia/reperfusion (I/R) injury. The normal group (n=10), model group (lower extremity I/R injury model, n=...
COVID-19 IgG/IgM patterns, early IL-6 elevation and long-term radiological sequelae in 75 patients hospitalized due to interstitial pneumonia followed up from 3 to 12 months.
PloS one
Feb 22, 2022
BACKGROUND: COVID-19 pandemic resulted in about 165 million infections and 3.4 million deaths all over the world across 15 months. The most severe clinical presentation of COVID-19 diseases is interstitial pneumonia.
Computational models in inflammatory bowel disease.
Clinical and translational science
Feb 5, 2022
Inflammatory bowel disease (IBD) is a chronic and relapsing disease with multiple underlying influences and notable heterogeneity among its clinical and response-to-treatment phenotypes. There is no cure for IBD, and none of the currently available t...
Novel in Vivo and in Vitro Pharmacokinetic/Pharmacodynamic-Based Human Starting Dose Selection for Glofitamab.
Journal of pharmaceutical sciences
Dec 22, 2021
We present a novel approach for first-in-human (FIH) dose selection of the CD20xCD3 bispecific antibody, glofitamab, based on pharmacokinetic/pharmacodynamic (PKPD) assessment in cynomolgus monkeys to select a high, safe starting dose, with cytokine ...
Prospective comparative study of postoperative systemic inflammatory syndrome in robot-assisted vs. open kidney transplantation.
World journal of urology
Oct 16, 2021
PURPOSE: Robot-assisted kidney transplant (RAKT) recently proved to provide functional results similar to the preferred open kidney transplant (OKT), but with inferior wound morbidity. In a comparative prospective study, we explored the systemic infl...
The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCT.
PloS one
Mar 23, 2021
The characteristics and evolution of pulmonary fibrosis in patients with coronavirus disease 2019 (COVID-19) have not been adequately studied. AI-assisted chest high-resolution computed tomography (HRCT) was used to investigate the proportion of COVI...
Host-dependent molecular factors mediating SARS-CoV-2 infection to gain clinical insights for developing effective targeted therapy.
Molecular genetics and genomics : MGG
Mar 20, 2021
Coronavirus disease 2019 (COVID-19), a recent viral pandemic that first began in December 2019, in Hunan wildlife market, Wuhan, China. The infection is caused by a coronavirus, SARS-CoV-2 and clinically characterized by common symptoms including fev...
IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysis.
PLoS computational biology
Sep 30, 2020
During these days of global emergency for the COVID-19 disease outbreak, there is an urgency to share reliable information able to help worldwide life scientists to get better insights and make sense of the large amount of data currently available. I...
Computer-assisted prediction of atherosclerotic intimal thickness based on weight of adrenal gland, interleukin-6 concentration, and neural networks.
The Journal of international medical research
Apr 30, 2019
OBJECTIVE: Atherosclerosis (AS) is the main pathological basis of ischemic cardio-cerebrovascular diseases, and the intimal thickness (IT) of large arteries is regarded as a powerful evaluation indicator for AS. We established an effective neural net...
Neuroprotective role of 6-Gingerol-rich fraction of Zingiber officinale (Ginger) against acrylonitrile-induced neurotoxicity in male Wistar rats.
Journal of basic and clinical physiology and pharmacology
Dec 22, 2018
Background Acrylonitrile (AN) is a neurotoxin that is widely used to manufacture synthetic fibres, plastics and beverage containers. Recently, we reported the ameliorative role of 6-gingerol-rich fraction from Zingiber officinale (Ginger, GRF) on the...
Cerebral Cortex
Fatty Alcohols
Rats
Zingiber officinale
Nitric Oxide
Glutathione Transferase
Malondialdehyde
Superoxide Dismutase
Catechols
Inflammation
Glutathione Peroxidase
Neuroprotection
Glutathione
Catalase
Acrylonitrile
Lipid Peroxidation
Tumor Necrosis Factor-alpha
Oxidative Stress
Interleukin-6
Antioxidants
Animals
Plant Extracts
Male
Rats, Wistar
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