AIMC Topic: Liver Cirrhosis

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Fibro predict a machine learning risk score for advanced liver fibrosis in the general population using Israeli electronic health records.

Scientific reports
Liver diseases, notably cirrhosis, pose a substantial global health challenge, resulting in millions of annual deaths. Existing diagnostic methods primarily target high-risk groups, leaving a significant portion of patients undiagnosed. This study ai...

MRI-based machine-learning radiomics of the liver to predict liver-related events in hepatitis B virus-associated fibrosis.

European radiology experimental
BACKGROUND: The onset of liver-related events (LREs) in fibrosis indicates a poor prognosis and worsens patients' quality of life, making the prediction and early detection of LREs crucial. The aim of this study was to develop a radiomics model using...

Serological proteomic characterization for monitoring liver fibrosis regression in chronic hepatitis B patients on treatment.

Nature communications
Longitudinal serological proteomic dynamics during antiviral therapy (AVT) in chronic hepatitis B (CHB) patients with liver fibrosis remain poorly characterized. Here, using four-dimensional data-independent acquisition mass spectrometry (4D-DIA-MS),...

Deep Learning-aided H-MR Spectroscopy for Differentiating between Patients with and without Hepatocellular Carcinoma.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
PURPOSE: Among patients with hepatitis B virus-associated liver cirrhosis (HBV-LC), there may be differences in the hepatic parenchyma between those with and without hepatocellular carcinoma (HCC). Proton MR spectroscopy (H-MRS) is a well-established...

A Machine Learning-Based Prognostication Model Enhances Prediction of Early Hepatic Encephalopathy in Patients With Noncancer-Related Cirrhosis: Multicenter Longitudinal Cohort Study in Taiwan.

JMIR medical informatics
BACKGROUND: Hepatic encephalopathy (HE) contributes significantly to mortality among patients with liver cirrhosis. Early prediction of HE is essential for clinical decision-making, yet remains challenging-particularly in noncancer-related cirrhosis ...

In-depth bioinformatics analysis uncovers the crosstalk genes and immune interactions among diagnostic markers linked to natural killer cells in patients with cirrhosis and sepsis.

Clinical and experimental medicine
Patients with cirrhosis face an elevated risk of developing sepsis, leading to an escalating mortality rate. This study focuses on the link between natural killer (NK) cells, cirrhosis, and sepsis. Our goal is to identify NK cell-related genes that c...

Innovative machine learning approach for liver fibrosis and disease severity evaluation in MAFLD patients using MRI fat content analysis.

Clinical and experimental medicine
This study employed machine learning models to quantitatively analyze liver fat content from MRI images for the evaluation of liver fibrosis and disease severity in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). A total o...

Identification of CTSK as a TLR-related critical biomarker in liver cirrhosis via integrative bioinformatics and pathological characterization.

Scientific reports
Liver cirrhosis (LC) is a common chronic disease worldwide with a poor prognosis, and its pathogenesis has not been fully elucidated. Toll-like receptors (TLRs) are crucial in LC progression. Here, we identified TLR-related genes, providing novel ins...

Predicting Morbidity and Mortality After Transjugular Intrahepatic Portosystemic Shunt Placement: A Review of Existing Models and Future Directions.

Techniques in vascular and interventional radiology
Transjugular intrahepatic portosystemic shunt (TIPS) is a key therapeutic intervention in the management of portal hypertension and its complications, such as variceal bleeding, hepatic hydrothorax, and refractory ascites. TIPS has historically been ...