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Liver Cirrhosis

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Golgi protein 73: charting new territories in diagnosing significant fibrosis in MASLD: a prospective cross-sectional study.

Frontiers in endocrinology
OBJECTIVES: To explore the correlation between serum Golgi protein 73 (GP73) levels and the degree of fibrosis in Metabolic dysfunction associated steatotic liver disease (MASLD); to establish a non-invasive diagnostic algorithm based on serum GP73 a...

Deep Learning and Hyperspectral Imaging for Liver Cancer Staging and Cirrhosis Differentiation.

Journal of biophotonics
Liver malignancies, particularly hepatocellular carcinoma (HCC), pose a formidable global health challenge. Conventional diagnostic techniques frequently fall short in precision, especially at advanced HCC stages. In response, we have developed a nov...

A machine learning based algorithm accurately stages liver disease by quantification of arteries.

Scientific reports
A major histologic feature of cirrhosis is the loss of liver architecture with collapse of tissue and vascular changes per unit. We developed qVessel to quantify the arterial density (AD) in liver biopsies with chronic disease of varied etiology and ...

Development and validation of a machine learning-based prediction model for hepatorenal syndrome in liver cirrhosis patients using MIMIC-IV and eICU databases.

Scientific reports
Hepatorenal syndrome (HRS) is a key contributor to poor prognosis in liver cirrhosis. This study aims to leverage the database to build a predictive model for early identification of high-risk patients. From two sizable public databases, we retrieved...

MERIT: Multi-view evidential learning for reliable and interpretable liver fibrosis staging.

Medical image analysis
Accurate staging of liver fibrosis from magnetic resonance imaging (MRI) is crucial in clinical practice. While conventional methods often focus on a specific sub-region, multi-view learning captures more information by analyzing multiple patches sim...

FibrAIm - The machine learning approach to identify the early stage of liver fibrosis and steatosis.

International journal of medical informatics
BACKGROUND: Early recognition of steatosis (fatty liver) and fibrosis in liver health is crucial for effectively managing and preventing the possibility of liver dysfunction. Detecting steatosis helps identify individuals at risk of liver-related dis...

Machine learning-based plasma metabolomics for improved cirrhosis risk stratification.

BMC gastroenterology
BACKGROUND: Cirrhosis is a leading cause of mortality in patients with chronic liver disease (CLD). The rapid development of metabolomic technologies has enabled the capture of metabolic changes related to the progression of cirrhosis.

Identifying liver cirrhosis in patients with chronic hepatitis B: an interpretable machine learning algorithm based on LSM.

Annals of medicine
BACKGROUND: Chronic hepatitis B (CHB) is a common cause of liver cirrhosis (LC), a condition associated with an unfavourable prognosis. Therefore, timely diagnosis of LC in CHB patients is crucial.

Machine learning-based models for advanced fibrosis in non-alcoholic steatohepatitis patients: A cohort study.

World journal of gastroenterology
BACKGROUND: The global prevalence of non-alcoholic steatohepatitis (NASH) and its associated risk of adverse outcomes, particularly in patients with advanced liver fibrosis, underscores the importance of early and accurate diagnosis.

Factor enhanced DeepSurv: A deep learning approach for predicting survival probabilities in cirrhosis data.

Computers in biology and medicine
BACKGROUND: Over the years, various models, including both traditional and machine learning models, have been employed to predict survival probabilities for diverse survival datasets. The objective is to obtain models that provide more accurate estim...