AIMC Topic: Liver
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Excited state kinetics of tryptophan and NAD(P)H in blood plasma of normal and abnormal liver conditions: A tool to understand the metabolic changes and classification.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Feb 6, 2025
Early diagnosis at the metabolomic level is crucial for the treatment of liver cirrhosis and hepatocellular carcinoma (HCC). In this study, attempts were made to investigate the excited-state kinetics of intrinsic fluorophores, tryptophan and nicotin...
Evaluating the synergistic use of advanced liver models and AI for the prediction of drug-induced liver injury.
Expert opinion on drug metabolism & toxicology
Feb 2, 2025
INTRODUCTION: Drug-induced liver injury (DILI) is a leading cause of acute liver failure. Hepatotoxicity typically occurs only in a subset of individuals after prolonged exposure and constitutes a major risk factor for the termination of drug develop...
SDR-Former: A Siamese Dual-Resolution Transformer for liver lesion classification using 3D multi-phase imaging.
Neural networks : the official journal of the International Neural Network Society
Feb 1, 2025
Automated classification of liver lesions in multi-phase CT and MR scans is of clinical significance but challenging. This study proposes a novel Siamese Dual-Resolution Transformer (SDR-Former) framework, specifically designed for liver lesion class...
Identification of hub biomarkers in liver post-metabolic and bariatric surgery using comprehensive machine learning (experimental studies).
International journal of surgery (London, England)
Feb 1, 2025
BACKGROUND: The global prevalence of non-alcoholic fatty liver disease (NAFLD) is approximately 30%, and the condition can progress to non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. Metabolic and bariatric surgery (MBS) has b...
Impact of deep learning reconstructions on image quality and liver lesion detectability in dual-energy CT: An anthropomorphic phantom study.
Medical physics
Jan 30, 2025
BACKGROUND: Deep learning image reconstruction (DLIR) algorithms allow strong noise reduction while preserving noise texture, which may potentially improve hypervascular focal liver lesions.
The impact of the novel CovBat harmonization method on enhancing radiomics feature stability and machine learning model performance: A multi-center, multi-device study.
European journal of radiology
Jan 29, 2025
PURPOSE: This study aims to assess whether the novel CovBat harmonization method can further reduce radiomics feature variability from different imaging devices in multi-center studies and improve machine learning model performance compared to the Co...
A machine learning based algorithm accurately stages liver disease by quantification of arteries.
Scientific reports
Jan 24, 2025
A major histologic feature of cirrhosis is the loss of liver architecture with collapse of tissue and vascular changes per unit. We developed qVessel to quantify the arterial density (AD) in liver biopsies with chronic disease of varied etiology and ...
Machine learning model to predict the adherence of tuberculosis patients experiencing increased levels of liver enzymes in Indonesia.
PloS one
Jan 24, 2025
Indonesia is still the second-highest tuberculosis burden country in the world. The antituberculosis adverse drug reaction and adherence may influence the success of treatment. The objective of this study is to define the model for predicting the adh...
iDIA-QC: AI-empowered data-independent acquisition mass spectrometry-based quality control.
Nature communications
Jan 21, 2025
Quality control (QC) in mass spectrometry (MS)-based proteomics is mainly based on data-dependent acquisition (DDA) analysis of standard samples. Here, we collect 2754 files acquired by data independent acquisition (DIA) and paired 2638 DDA files fro...
Analyzing the relationship between gene expression and phenotype in space-flown mice using a causal inference machine learning ensemble.
Scientific reports
Jan 18, 2025
Spaceflight has several detrimental effects on human and rodent health. For example, liver dysfunction is a common phenotype observed in space-flown rodents, and this dysfunction is partially reflected in transcriptomic changes. Studies linking trans...
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