BACKGROUND: The incidence of cardiovascular metabolic diseases (CMD) is increasing, and depression in CMD patients significantly impacts prognosis. Therefore, this study aimed to develop and validate a predictive model for depression in CMD patients ...
A significant barrier to developing disease-modifying therapies for spinocerebellar ataxias (SCAs) and multiple system atrophy of the cerebellar type (MSA-C) is the scarcity of tools to measure disease progression sensitively in clinical trials. Wear...
Journal of applied clinical medical physics
Sep 1, 2025
BACKGROUND: Efficient workflows are essential for timely, high-quality radiotherapy. In 2020, an internal audit identified key workflow bottlenecks, including long patient wait times, suboptimal treatment planning, and inadequate quality control. Acc...
Journal of neuroradiology = Journal de neuroradiologie
Sep 1, 2025
INTRODUCTION: Early-onset Alzheimer's disease (EOAD) population is a clinically, genetically and pathologically heterogeneous condition. Identifying biomarkers related to disease progression is crucial for advancing clinical trials and improving ther...
BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS characterized by a heterogeneous disease trajectory, highlighting the need for biomarkers to predict disease activity. Current disease-monitorin...
Overtraining syndrome (OTS) poses a critical challenge in youth soccer, particularly during periods of rapid physiological maturation combined with high training demands. This study aimed to develop and validate a multidimensional prediction model fo...
Preterm birth and very low birthweight (VP/VLBW) are associated with poorer health-related quality of life (HRQoL) outcomes extending into adulthood, yet it remains unclear how these effects differ across sociodemographic subgroups. This study aimed ...
The impact of social determinants of health (SDoH) on periodontal disease (PD) is critical to study, as a deeper understanding of SDoH offers significant potential to inform policy and help clinicians provide holistic patient care. The use of machine...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Aug 1, 2025
INTRODUCTION: Clinical diagnosis (normal cognition, mild cognitive impairment [MCI], dementia) is critical for understanding cognitive impairment and dementia but can be resource intensive and subject to inconsistencies due to complex clinical judgme...
Ecotoxicology and environmental safety
Aug 1, 2025
BACKGROUND: Exposure to heavy metals represents a significant risk factor for hypertension and blood pressure disorders. Notably, current evidence indicates that the key biological processes of oxidative stress, inflammation, and endothelial dysfunct...
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