STUDY OBJECTIVES: Chronic wounds represent a significant economic and personal burden. For their successful treatment, the causes must be known and treated. Wounds caused by pyoderma gangrenosum (PG), a rare inflammatory skin disease, are often misdi...
BACKGROUND: Drug-drug interactions (DDIs) are a major concern, especially for older adults taking multiple medications. Although Health Canada and the US Food and Drug Administration (FDA) use population-based studies to identify adverse drug events,...
BACKGROUND: Machine learning (ML) has shown great potential in recognizing complex disease patterns and supporting clinical decision-making. Diabetic foot ulcers (DFUs) represent a significant multifactorial medical problem with high incidence and se...
BACKGROUND: Offline reinforcement learning (RL) has been increasingly applied to clinical decision-making problems. However, due to the lack of a standardized pipeline, prior work often relied on strategies that may lead to overfitted policies and in...
Archives of orthopaedic and trauma surgery
Oct 10, 2025
AIMS: The aim of this retrospective study was the evaluation of the patient-reported and radiological outcome of intravenous Iloprost therapy in the treatment of spontaneous osteonecrosis of the knee (SONK).
BACKGROUND: Controlling delayed cerebral ischemia (DCI) is crucial for improving the prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH). This study aimed to identify prognostic factors in patients with aSAH in Japan.
Type 2 diabetes mellitus (T2DM) is a severe metabolic disorder in which pancreatic injury plays a pivotal role in disease progression. Tanshinone IIA (TanIIA), a bioactive compound extracted from Salvia miltiorrhiza, has shown therapeutic potential i...
BACKGROUND: Lysosomal storage diseases (LSDs) are a group of genetically heterogeneous inherited metabolic disorders that affect the functions of the lysosomes in different human tissues. Mucopolysaccharidosis IIIB (MPS IIIB), Sanfilippo B syndrome, ...
Medical science monitor : international medical journal of experimental and clinical research
Oct 10, 2025
BACKGROUND Perineural invasion (PNI) is strongly associated with poor clinical outcomes in colorectal cancer (CRC). However, no machine learning diagnostic model based on pathomics has been established for PNI detection in CRC. To address this issue,...
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