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Comprehensive integration of single-cell and bulk transcriptome to reveal plasma cell heterogeneity and a prognosis signature in head and neck squamous cell carcinoma.
Oral oncology
Aug 14, 2025
Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy with a low five-year survival rate, emphasising the urgent need for effective prognostic biomarkers to guide patient stratification and personalised treatment. Plasma cells (PCs)...
Screening, Validation, and Machine Learning-Based Evaluation of Serum Protein Biomarkers for Esophageal Squamous Cell Carcinoma Based on Single-Cell Subtype-Specific Genes.
Journal of proteome research
Aug 12, 2025
Cellular heterogeneity of epithelial cells and fibroblasts is critical in esophageal squamous cell carcinoma development (ESCC). Identifying dysregulated subtype-specific genes in these cells is essential for early diagnosis and treatment. In this st...
Robotic arm vs. stereotactic frame in deep brain stimulation surgery for movement disorders: a retrospective cohort study.
Acta neurochirurgica
Aug 12, 2025
BACKGROUND: Recently, robotic arms have been incorporated into the implantation of electrodes for deep brain stimulation (DBS).This study aimed to determine the accuracy of brain electrode placement, initial clinical efficacy, and safety profile of t...
MRI-derived quantification of hepatic vessel-to-volume ratios in chronic liver disease using a deep learning approach.
European radiology experimental
Aug 12, 2025
BACKGROUND: We aimed to quantify hepatic vessel volumes across chronic liver disease stages and healthy controls using deep learning-based magnetic resonance imaging (MRI) analysis, and assess correlations with biomarkers for liver (dys)function and ...
The association of symptoms, pulmonary function test and computed tomography in interstitial lung disease at the onset of connective tissue disease: an observational study with artificial intelligence analysis of high-resolution computed tomography.
Rheumatology international
Aug 12, 2025
Interstitial lung disease (ILD) is a common and serious organ manifestation in patients with connective tissue disease (CTD), but it is uncertain whether there is a difference in ILD between symptomatic and asymptomatic patients. Therefore, we conduc...
Exploring GPT-4o's multimodal reasoning capabilities with panoramic radiograph: the role of prompt engineering.
Clinical oral investigations
Aug 12, 2025
OBJECTIVES: The aim of this study was to evaluate GPT-4o's multimodal reasoning ability to review panoramic radiograph (PR) and verify its radiologic findings, while exploring the role of prompt engineering in enhancing its performance.
Domain Knowledge Inclusive Monotonic Neural Network Guides Patient-Specific Induction of General Anesthesia Dosing.
A&A practice
Aug 12, 2025
BACKGROUND: Postinduction hypotension is a well-known risk factor for adverse postoperative outcomes. Anesthesiologists estimate anesthetic dosages based on a patient's chart and domain knowledge. Machine learning is increasingly applied in predictin...
Screening for Parkinson's disease using "computer vision".
PloS one
Aug 12, 2025
BACKGROUND: Identifying bradykinesia is crucial for diagnosing Parkinson's disease (PD). Traditionally, the finger-tapping test has been used, relying on subjective assessments by physicians. Computer vision offers a non-contact and cost-effective al...
Multimodal data fusion with irregular PSA kinetics for automated prostate cancer grading.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Aug 11, 2025
Prostate cancer (PCa) detection and accurate grading remain critical challenges in medical diagnostics. While deep learning has shown promise in medical image analysis, existing computer-aided diagnosis approaches primarily focus on image recognition...
Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome.
Proceedings of the National Academy of Sciences of the United States of America
Aug 11, 2025
People living with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) experience heterogeneous and debilitating symptoms that lack sufficient biological explanation, compounded by the absence of accurate, noninvasive diagnostic tools. To add...
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