AIMC Topic: Membrane Potential, Mitochondrial
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Mitochondrial dysfunction and cell death induced by Toona sinensis leaf extracts through MEK/ERK signaling in glioblastoma cells.
PloS one
May 9, 2025
Toona sinensis, a kind of phytochemicals in traditional Chinese medicine widely used in South-East Asia, has been recognized for its anticancer properties, particularly against various types of cancer. We aimed to evaluate the effectiveness of T. sin...
Hybrid non-animal modeling: A mechanistic approach to predict chemical hepatotoxicity.
Journal of hazardous materials
Apr 12, 2024
Developing mechanistic non-animal testing methods based on the adverse outcome pathway (AOP) framework must incorporate molecular and cellular key events associated with target toxicity. Using data from an in vitro assay and chemical structures, we a...
Machine learning models on chemical inhibitors of mitochondrial electron transport chain.
Journal of hazardous materials
Dec 10, 2021
Chemicals can induce adverse effects in humans by inhibiting mitochondrial electron transport chain (ETC) such as disrupting mitochondrial membrane potential, enhancing oxidative stress and causing some diseases. Thus, identifying ETC inhibitors (ETC...
Smart Plasmonic Nanorobot for Real-Time Monitoring Cytochrome c Release and Cell Acidification in Apoptosis during Electrostimulation.
Analytical chemistry
Dec 4, 2018
Cytochrome c (Cyt c) release and cellular pH change are two important mediators of apoptosis. Effective methods to regulate or monitor such two events are therefore highly desired for apoptosis research and cancer cell therapy. Herein, we exploited e...
Transcriptomic alterations in Sitophilus zeamais in response to allyl isothiocyanate fumigation.
Pesticide biochemistry and physiology
Oct 11, 2016
To study the fumigation mechanisms of Allyl isothiocyanate (AITC) a promising biorational alternative to present fumigants (phosphine and methyl bromide), and provide theoretical basis for its further development in the control of stored grain pests,...
Cytotoxic response of platinum-coated gold nanorods in human breast cancer cells at very low exposure levels.
Environmental toxicology
Apr 6, 2015
Because of unique optical behavior gold nanorods (GNRs) have attracted attention for the application in biomedical field such as bio-sensing, bio-imaging and hyperthermia. However, toxicological response of GNRs is controversial due to their differen...
Breast Neoplasms
Real-Time Polymerase Chain Reaction
RNA, Messenger
Apoptosis
Reactive Oxygen Species
Caspase 3
Particle Size
MCF-7 Cells
Humans
Female
Caspase 9
G1 Phase Cell Cycle Checkpoints
Down-Regulation
Gold
Up-Regulation
Membrane Potential, Mitochondrial
Nanotubes
Platinum
Acetylcysteine
Proto-Oncogene Proteins c-bcl-2
Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning.
Scientific reports
Jan 26, 2015
In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and mitochondrial morpho-functional changes. Empirical evidence suggests these aberratio...
Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning.
Biochimica et biophysica acta
Nov 13, 2014
Understanding the processes of mitochondrial dynamics (fission, fusion, biogenesis, and mitophagy) has been hampered by the lack of automated, deterministic methods to measure mitochondrial morphology from microscopic images. A method to quantify mit...
Imaging, Three-Dimensional
Mice
Cell Line
Cell Survival
Artificial Intelligence
Phenotype
Animals
Stress, Physiological
Cell Membrane
Electron Transport
tert-Butylhydroperoxide
Membrane Potential, Mitochondrial
Oxidants
Mitochondria
Sodium-Potassium-Exchanging ATPase
Carbonyl Cyanide m-Chlorophenyl Hydrazone
Cell Respiration
IGF-1 stabilizes goat sperm mitochondrial transmembrane potential and reduces dna fragmentation.
Cryo letters
Jan 1, 2023
BACKGROUND: Antioxidant present in sperm cells protects them from oxidative damage. However, sperm are more susceptible to peroxidative damages due to the loss of these enzymes during cryopreservation and their survival and fertility may be compromis...
Cytotoxicity and molecular docking analysis of racemolactone I, a new sesquiterpene lactone isolated from .
Pharmaceutical biology
Dec 1, 2021
CONTEXT: Traditionally, Hook. f. (Asteraceae) has been reported to be effective in cancer treatment which motivated the authors to explore the plant for novel anticancer compounds.
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