AIMC Topic: Mice, Inbred C57BL
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3-Dimensional Immunostaining and Automated Deep-Learning Based Analysis of Nerve Degeneration.
International journal of molecular sciences
Nov 26, 2022
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease driven by inflammation and demyelination in the brain, spinal cord, and optic nerve. Optic neuritis, characterized by inflammation and demyelination of the optic nerve, is a sympt...
Deep learning-based approach to the characterization and quantification of histopathology in mouse models of colitis.
PloS one
Aug 29, 2022
Inflammatory bowel disease (IBD) is a chronic immune-mediated disease of the gastrointestinal tract. While therapies exist, response can be limited within the patient population. Researchers have thus studied mouse models of colitis to further unders...
Protection against ulcerative colitis and colorectal cancer by evodiamine via anti‑inflammatory effects.
Molecular medicine reports
Apr 1, 2022
Evodiamine (Evo) is an alkaloid that can be extracted from the berry fruit and has been reported to exert various pharmacological effects, such as antidiarrheal, antiemetic and antiulcer effects. , the potential effects of Evo were investigated in a...
Deep learning approach identified a gene signature predictive of the severity of renal damage caused by chronic cadmium accumulation.
Journal of hazardous materials
Mar 27, 2022
Epidemiology studies have indicated that environmental cadmium exposure, even at low levels, will result in chronic cadmium accumulation in the kidney with profound adverse consequences and that the diabetic population is more susceptible. However, t...
Automated characterisation of microglia in ageing mice using image processing and supervised machine learning algorithms.
Scientific reports
Feb 2, 2022
The resident macrophages of the central nervous system, microglia, are becoming increasingly implicated as active participants in neuropathology and ageing. Their diverse and changeable morphology is tightly linked with functions they perform, enabli...
Automated procedure to assess pup retrieval in laboratory mice.
Scientific reports
Jan 31, 2022
All mammalian mothers form some sort of caring bond with their infants that is crucial to the development of their offspring. The Pup Retrieval Test (PRT) is the leading procedure to assess pup-directed maternal care in laboratory rodents, used in a ...
Integrated deep learning framework for accelerated optical coherence tomography angiography.
Scientific reports
Jan 25, 2022
Label-free optical coherence tomography angiography (OCTA) has become a premium imaging tool in clinics to obtain structural and functional information of microvasculatures. One primary technical drawback for OCTA, however, is its imaging speed. The ...
The Anti-Adiposity Mechanisms of Ampelopsin and Vine Tea Extract in High Fat Diet and Alcohol-Induced Fatty Liver Mouse Models.
Molecules (Basel, Switzerland)
Jan 18, 2022
(AG) is an ancient medicinal plant that is mainly distributed and used in southwest China. It exerts therapeutic effects, such as antioxidant, anti-diabetic, and anti-inflammatory activities, reductions in blood pressure and cholesterol and hepatopr...
Rapid video-based deep learning of cognate versus non-cognate T cell-dendritic cell interactions.
Scientific reports
Jan 11, 2022
Identification of cognate interactions between antigen-specific T cells and dendritic cells (DCs) is essential to understanding immunity and tolerance, and for developing therapies for cancer and autoimmune diseases. Conventional techniques for selec...
Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and deficient mice.
Aging
Dec 19, 2021
Pelvic organ prolapse is a worldwide health problem to elderly women. Understanding its pathogenesis and an ideal animal model are crucial to developing promising treatments. The present study aimed to investigate new clinical significance and detail...
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