AIMC Topic: Mice, Inbred C57BL

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Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning.

Proceedings of the National Academy of Sciences of the United States of America Feb 26, 2019
A varying oxygen environment is known to affect cellular function in disease as well as activity of various therapeutics. For transient structures, whether they are unconstrained therapeutic transplants, migrating cells during tumor metastasis, or ce...
Magnetic Resonance Imaging Cluster Analysis Mice, Inbred C57BL Oxygen Machine Learning Animals Imaging, Three-Dimensional Alginates Islets of Langerhans Transplantation Prostheses and Implants Fluorine Immunity Halogenation Biocompatible Materials Partial Pressure Insulin Secretion
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Unlocking HDR-mediated nucleotide editing by identifying high-efficiency target sites using machine learning.

Scientific reports Feb 26, 2019
Editing individual nucleotides is a crucial component for validating genomic disease association. It is currently hampered by CRISPR-Cas-mediated "base editing" being limited to certain nucleotide changes, and only achievable within a small window ar...
Mice Mice, Inbred C57BL CRISPR-Cas Systems Mutation Gene Editing Oligodeoxyribonucleotides DNA Breaks, Double-Stranded DNA Repair RNA, Guide, CRISPR-Cas Systems Machine Learning Animals
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Craniobot: A computer numerical controlled robot for cranial microsurgeries.

Scientific reports Jan 31, 2019
Over the last few decades, a plethora of tools has been developed for neuroscientists to interface with the brain. Implementing these tools requires precisely removing sections of the skull to access the brain. These delicate cranial microsurgical pr...
Computer Simulation Animals Mice, Inbred C57BL Robotics Microsurgery Automation Skull Numerical Analysis, Computer-Assisted
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Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning.

eLife Jan 18, 2019
The highly organized spatial arrangement of sensory hair cells in the organ of Corti is essential for inner ear function. Here, we report a new analytical pipeline, based on optical clearing of tissue, for the construction of a single-cell resolution...
Machine Learning Animals Age Factors Mice, Inbred C57BL Microscopy, Fluorescence Hair Cells, Auditory Organ of Corti Spatial Analysis Pattern Recognition, Automated Immunohistochemistry Cochlea
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The onset and post-onset auditory responses of cochlear nucleus neurons are modulated differently by cortical activation.

Hearing research Dec 31, 2018
Auditory cortex exhibit a capacity of modulating the functions of subcortical auditory nuclei and even inner ear through descending pathways. The cochlear nucleus (CN), which acts as the gateway from the auditory periphery to the central auditory sys...
Mice, Inbred C57BL Auditory Pathways Female Reaction Time Cochlear Nerve Animals Cochlear Nucleus Acoustic Stimulation Time Factors Evoked Potentials, Auditory Auditory Cortex
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Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia.

Oxidative medicine and cellular longevity Dec 18, 2018
Postcardiac arrest syndrome yields poor neurological outcomes, but the mechanisms underlying this condition remain poorly understood. Autophagy plays an important role in neuronal apoptosis induced by ischemia. However, whether autophagy is involved ...
Transient Receptor Potential Channels Reperfusion Injury Astrocytes Autophagy Cells, Cultured Mice Neurons Phthalimides Animals Disease Models, Animal Ischemic Attack, Transient Male Apoptosis Microtubule-Associated Proteins Oxidative Stress Mice, Inbred C57BL Quinolines
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Morphometric analysis of peripheral myelinated nerve fibers through deep learning.

Journal of the peripheral nervous system : JPNS Dec 11, 2018
Irrespective of initial causes of neurological diseases, these disorders usually exhibit two key pathological changes-axonal loss or demyelination or a mixture of the two. Therefore, vigorous quantification of myelin and axons is essential in studyin...
Animals Pattern Recognition, Automated Deep Learning Nerve Fibers, Myelinated Mice, Knockout Microscopy Axons Mice Mice, Inbred C57BL
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Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1.

British journal of pharmacology Dec 4, 2018
BACKGROUND AND PURPOSE: Liquorice is the root of Glycyrrhiza glabra, which is a popular food in Europe and China that has previously shown benefits for skeletal fatigue and nutrient metabolism. However, the mechanism and active ingredients remain lar...
Glycyrrhiza Transcription, Genetic Muscular Atrophy Forkhead Box Protein O1 Mice, Inbred C57BL Dose-Response Relationship, Drug Muscle, Skeletal Structure-Activity Relationship Plant Roots Models, Molecular Molecular Structure Benzopyrans Male Mice Computational Biology Plant Extracts Machine Learning Animals
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Label-Free Identification of Lymphocyte Subtypes Using Three-Dimensional Quantitative Phase Imaging and Machine Learning.

Journal of visualized experiments : JoVE Nov 19, 2018
We describe here a protocol for the label-free identification of lymphocyte subtypes using quantitative phase imaging and machine learning. Identification of lymphocyte subtypes is important for the study of immunology as well as diagnosis and treatm...
Mice, Inbred C57BL Lymphocytes Humans Machine Learning Animals Imaging, Three-Dimensional Mice
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Automatic glomerular identification and quantification of histological phenotypes using image analysis and machine learning.

American journal of physiology. Renal physiology Sep 26, 2018
Current methods of scoring histological kidney samples, specifically glomeruli, do not allow for collection of quantitative data in a high-throughput and consistent manner. Neither untrained individuals nor computers are presently capable of identify...
Mice, Inbred C57BL Kidney Diseases Predictive Value of Tests Biopsy Workflow Kidney Glomerulus Microscopy Image Interpretation, Computer-Assisted Male Diagnosis, Computer-Assisted Rats Disease Models, Animal Humans Phenotype Machine Learning Pattern Recognition, Automated Female Software Species Specificity Reproducibility of Results Automation, Laboratory Mice, Transgenic Animals
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