AIMC Topic: Mice, Inbred C57BL

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[Determination of dacarbazine in the urine of mice with melanoma by high performance liquid chromatography].

Se pu = Chinese journal of chromatography Nov 8, 2020
Dacarbazine (DTIC) is a first-line chemotherapy drug that is widely used in clinical practice for malignant melanoma. DTIC is metabolized by the liver . Some drugs are excreted in urine in the form of a prototype. Hence, DTIC in urine can be monitore...
Mice, Inbred C57BL Melanoma Chromatography, High Pressure Liquid Animals Dacarbazine Mice
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A Deep Learning Approach to Antibiotic Discovery.

Cell Feb 20, 2020
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed pr...
Animals Drug Discovery Mice Mice, Inbred BALB C Machine Learning Anti-Bacterial Agents Clostridioides difficile Mice, Inbred C57BL Small Molecule Libraries Mycobacterium tuberculosis Cheminformatics Acinetobacter baumannii Thiadiazoles Databases, Chemical
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Machine learning-based automated phenotyping of inflammatory nocifensive behavior in mice.

Molecular pain Jan 1, 2020
The discovery and development of new and potentially nonaddictive pain therapeutics requires rapid, yet clinically relevant assays of nociception in preclinical models. A reliable and scalable automated scoring system for nocifensive behavior of mice...
Behavior, Animal Nociception Female Reproducibility of Results Animals Machine Learning Male Algorithms Mice Mice, Inbred C57BL Video Recording Automation
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Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body.

Cell Dec 12, 2019
Reliable detection of disseminated tumor cells and of the biodistribution of tumor-targeting therapeutic antibodies within the entire body has long been needed to better understand and treat cancer metastasis. Here, we developed an integrated pipelin...
Antibodies Neoplasm Metastasis Mice, SCID Drug Therapy, Computer-Assisted Animals Neoplasms Diagnosis, Computer-Assisted Deep Learning Mice Mice, Nude Mice, Inbred C57BL MCF-7 Cells Humans Software Tumor Microenvironment
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Machine Learning Approach for Predicting Past Environmental Exposures From Molecular Profiling of Post-Exposure Human Serum Samples.

Journal of occupational and environmental medicine Dec 1, 2019
OBJECTIVE: To develop an approach for a retrospective analysis of post-exposure serum samples using diverse molecular profiles.
Humans Machine Learning Biomarkers Female Adolescent Support Vector Machine Age Factors Disease Models, Animal Young Adult Adult Animals Male Smoking Tobacco Smoke Pollution Mice, Inbred C57BL Cotinine Environmental Exposure Sex Factors
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An End-to-end System for Automatic Characterization of Iba1 Immunopositive Microglia in Whole Slide Imaging.

Neuroinformatics Jul 1, 2019
Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. Detailed studies of the microglial response after TBI require high throughput quantification of changes in microglial count and morphology in histological se...
White Matter Brain Injuries, Traumatic Brain Mice, Inbred C57BL Animals Microglia Deep Learning Image Processing, Computer-Assisted Mice
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[Astragalus polysaccharide combined with cisplatin inhibits growth of recurrent tumor and down-regulats the expression of CD44, CD62P and osteopontin in tumor tissues in mice bearing Lewis lung cancer].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology Dec 1, 2018
Objective To investigate the effects of Astragalus polysaccharide (APS) combined with cisplatin (DDP) on the pathological morphology of recurrent tumor and the expression of metastasis-related proteins CD44, CD62P and osteopontin (OPN) following Lewi...
Mice, Inbred C57BL Neoplasm Recurrence, Local Polysaccharides Cisplatin Animals Cell Line, Tumor Lung Neoplasms Mice Hyaluronan Receptors P-Selectin Osteopontin Random Allocation Astragalus Plant Carcinoma, Lewis Lung
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[Effects of treatment on ultrastructure of olfactory bulb and GFAP expression in mice with Parkinson's disease].

Zhongguo zhen jiu = Chinese acupuncture & moxibustion Oct 12, 2018
OBJECTIVE: To observe the effects of treatment on the ultrastructure of olfactory bulb and the expression of substantia nigra glial fibrillary acidic protein (GFAP) in mice with Parkinson's disease (PD) induced by lipopolysaccharide (LPS), and to pr...
Male Rats Animals Parkinson Disease Rats, Sprague-Dawley Glial Fibrillary Acidic Protein Mice, Inbred C57BL Electroacupuncture Olfactory Bulb
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Single subject transcriptome analysis to identify functionally signed gene set or pathway activity.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing Jan 1, 2018
Analysis of single-subject transcriptome response data is an unmet need of precision medicine, made challenging by the high dimension, dynamic nature and difficulty in extracting meaningful signals from biological or stochastic noise. We have propose...
Humans Precision Medicine Female Animals Male Mice, 129 Strain Gene Expression Profiling Gene Regulatory Networks Mice, Inbred DBA Mice, Inbred NZB Diet, High-Fat Gene Ontology Oligonucleotide Array Sequence Analysis Mice, Inbred Strains Mice Computational Biology Databases, Genetic Mice, Inbred C57BL
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[Excessive fluoride increases the expression of osteocalcin in the mouse testis].

Zhonghua nan ke xue = National journal of andrology Sep 1, 2017
OBJECTIVE: To observe the influence of excessive fluoride on the levels of osteocalcin and testosterone in the testis of the male mouse.
Sodium Fluoride Osteocalcin Fluorides Random Allocation Animals Fluoride Poisoning Male Mice Testis Mice, Inbred C57BL
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