AIMC Topic: Mice, Inbred C57BL

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Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia.

Oxidative medicine and cellular longevity Dec 18, 2018
Postcardiac arrest syndrome yields poor neurological outcomes, but the mechanisms underlying this condition remain poorly understood. Autophagy plays an important role in neuronal apoptosis induced by ischemia. However, whether autophagy is involved ...
Astrocytes Autophagy Neurons Phthalimides Ischemic Attack, Transient Microtubule-Associated Proteins Quinolines Transient Receptor Potential Channels Cells, Cultured Animals Male Oxidative Stress Mice Disease Models, Animal Apoptosis Mice, Inbred C57BL Reperfusion Injury
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Morphometric analysis of peripheral myelinated nerve fibers through deep learning.

Journal of the peripheral nervous system : JPNS Dec 11, 2018
Irrespective of initial causes of neurological diseases, these disorders usually exhibit two key pathological changes-axonal loss or demyelination or a mixture of the two. Therefore, vigorous quantification of myelin and axons is essential in studyin...
Animals Deep Learning Mice Mice, Inbred C57BL Mice, Knockout Microscopy Axons Pattern Recognition, Automated Nerve Fibers, Myelinated
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Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1.

British journal of pharmacology Dec 4, 2018
BACKGROUND AND PURPOSE: Liquorice is the root of Glycyrrhiza glabra, which is a popular food in Europe and China that has previously shown benefits for skeletal fatigue and nutrient metabolism. However, the mechanism and active ingredients remain lar...
Computational Biology Plant Extracts Mice, Inbred C57BL Dose-Response Relationship, Drug Muscle, Skeletal Machine Learning Animals Male Mice Benzopyrans Glycyrrhiza Structure-Activity Relationship Transcription, Genetic Muscular Atrophy Forkhead Box Protein O1 Plant Roots Models, Molecular Molecular Structure
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Label-Free Identification of Lymphocyte Subtypes Using Three-Dimensional Quantitative Phase Imaging and Machine Learning.

Journal of visualized experiments : JoVE Nov 19, 2018
We describe here a protocol for the label-free identification of lymphocyte subtypes using quantitative phase imaging and machine learning. Identification of lymphocyte subtypes is important for the study of immunology as well as diagnosis and treatm...
Animals Imaging, Three-Dimensional Mice Mice, Inbred C57BL Lymphocytes Humans Machine Learning
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Automatic glomerular identification and quantification of histological phenotypes using image analysis and machine learning.

American journal of physiology. Renal physiology Sep 26, 2018
Current methods of scoring histological kidney samples, specifically glomeruli, do not allow for collection of quantitative data in a high-throughput and consistent manner. Neither untrained individuals nor computers are presently capable of identify...
Animals Male Diagnosis, Computer-Assisted Rats Disease Models, Animal Automation, Laboratory Phenotype Female Reproducibility of Results Workflow Kidney Glomerulus Microscopy Image Interpretation, Computer-Assisted Pattern Recognition, Automated Mice, Inbred C57BL Kidney Diseases Predictive Value of Tests Biopsy Humans Machine Learning Software Species Specificity Mice, Transgenic
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Deep learning-based quantification of abdominal fat on magnetic resonance images.

PloS one Sep 20, 2018
Obesity is increasingly prevalent and associated with increased risk of developing type 2 diabetes, cardiovascular diseases, and cancer. Magnetic resonance imaging (MRI) is an accurate method for determination of body fat volume and distribution. How...
Magnetic Resonance Imaging Phenotype Mice, Inbred C57BL Adipose Tissue Automation Apolipoproteins E Female Mice, Knockout Animals Subcutaneous Fat Organ Specificity Body Weight Male Diet, Western Abdominal Fat Deep Learning Mice, Inbred C3H Intra-Abdominal Fat
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DeepLabCut: markerless pose estimation of user-defined body parts with deep learning.

Nature neuroscience Aug 20, 2018
Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior in diverse settings, yet extracting particular aspects of a behavior for further analysis ca...
Transfer, Psychology Posture Mice, Inbred C57BL Odorants Algorithms Video Recording Psychomotor Performance Animals Behavior, Animal Male Humans Drosophila melanogaster Deep Learning Nerve Net Mice Neural Networks, Computer Behavior
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A Robotic System for Adaptive Training and Function Assessment of Forelimb Retraction in Mice.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society Aug 8, 2018
Rodent models are decisive for translational research in healthy and pathological conditions of motor function thanks to specific similarities with humans. Here, we present an upgraded version of the M-Platform, a robotic device previously designed t...
Cerebral Cortex Isometric Contraction Stroke Rehabilitation Friction Conditioning, Operant Forelimb Male Mice Mice, Inbred C57BL Robotics Female Psychomotor Performance Biomechanical Phenomena Animals
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A Novel Morphological Marker for the Analysis of Molecular Activities at the Single-cell Level.

Cell structure and function Jun 29, 2018
For more than a century, hematoxylin and eosin (H&E) staining has been the de facto standard for histological studies. Consequently, the legacy of histological knowledge is largely based on H&E staining. Due to the recent advent of multi-photon excit...
Animals Single-Cell Analysis Imaging, Three-Dimensional Biosensing Techniques Mice, Inbred C57BL Microscopy, Fluorescence Dogs Madin Darby Canine Kidney Cells Fluorescence Resonance Energy Transfer Machine Learning MAP Kinase Signaling System Mice, Transgenic
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Cell dynamic morphology classification using deep convolutional neural networks.

Cytometry. Part A : the journal of the International Society for Analytical Cytology May 15, 2018
Cell morphology is often used as a proxy measurement of cell status to understand cell physiology. Hence, interpretation of cell dynamic morphology is a meaningful task in biomedical research. Inspired by the recent success of deep learning, we here ...
Mice Neural Networks, Computer Mice, Inbred BALB C Databases, Factual Mice, Inbred C57BL Animals Lymphocytes Male Deep Learning
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