AIMC Topic: Mice, Inbred C57BL

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Recognition of early stage thigmotaxis in Morris water maze test with convolutional neural network.

PloS one May 3, 2018
The Morris water maze test (MWM) is a useful tool to evaluate rodents' spatial learning and memory, but the outcome is susceptible to various experimental conditions. Thigmotaxis is a commonly observed behavioral pattern which is thought to be relate...
Carotid Stenosis Spatial Memory Taxis Response Animals Male Mice Mice, Inbred C57BL Neural Networks, Computer Reaction Time Machine Learning Sensitivity and Specificity Swimming Carotid Artery, Common Maze Learning
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Computational Analysis of Cell Dynamics in Videos with Hierarchical-Pooled Deep-Convolutional Features.

Journal of computational biology : a journal of computational molecular cell biology Apr 25, 2018
Computational analysis of cellular appearance and its dynamics is used to investigate physiological properties of cells in biomedical research. In consideration of the great success of deep learning in video analysis, we first introduce two-stream co...
Algorithms Animals Male Mice Computational Biology Neural Networks, Computer Lymphocytes Mice, Inbred BALB C Mice, Inbred C57BL Video Recording Skin Diseases Skin Transplantation Cell Physiological Phenomena
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Cortical frequency-specific plasticity is independently induced by intracortical circuitry.

Neuroscience letters Dec 21, 2017
Auditory learning induces frequency-specific plasticity in the auditory cortex. Both the auditory cortex and thalamus are involved in the cortical plasticity; however, the precise role of the intracortical circuity remains unclear until the contribut...
Lidocaine Neurons Acoustic Stimulation Evoked Potentials, Auditory Auditory Cortex Animals Neuronal Plasticity Electric Stimulation Mice Action Potentials Thalamus Mice, Inbred C57BL Voltage-Gated Sodium Channel Blockers
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Fully automated, deep learning segmentation of oxygen-induced retinopathy images.

JCI insight Dec 21, 2017
Oxygen-induced retinopathy (OIR) is a widely used model to study ischemia-driven neovascularization (NV) in the retina and to serve in proof-of-concept studies in evaluating antiangiogenic drugs for ocular, as well as nonocular, diseases. The primary...
Algorithms Female Animals Male Deep Learning Image Processing, Computer-Assisted Observer Variation Mice, Transgenic Retinal Neovascularization Microscopy, Confocal Disease Models, Animal Mice, Inbred C57BL Oxygen
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Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway.

Biochemical and biophysical research communications Dec 18, 2017
Linarin, a natural flavonoid glycoside widely found in plants, has been reported to possess anti-inflammation, neuroprotection and osteogenic properties. However, its impact on osteoclast remains unclear. In the present study, the effects of linarin ...
Osteoblasts Glycosides Cells, Cultured Dose-Response Relationship, Drug Macrophages NF-kappa B Animals Osteogenesis Mice Signal Transduction RAW 264.7 Cells RANK Ligand Mice, Inbred C57BL
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Kaempferol modulates Angiopoietin-like protein 2 expression to lessen the mastitis in mice.

Pharmacological reports : PR Nov 22, 2017
BACKGROUND: Mastitis is inflammation of a breast (or udder). Angiopoietin-like protein 2 (ANGPTL2) has been found as a key inflammatory mediator in mastitis. Purpose of this research was to investigate the mechanisms about repressing effect of kaempf...
Mice, Inbred C57BL Animals Angiopoietin-Like Protein 2 Epithelial Cells Tumor Necrosis Factor-alpha Mice Peroxidase Kaempferols Mastitis Interleukin-6 Angiopoietin-like Proteins Inflammation Female
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Sparse Supervised Classification Methods Predict and Characterize Nanomaterial Exposures: Independent Markers of MWCNT Exposures.

Toxicologic pathology Sep 22, 2017
Recent experimental evidence indicates significant pulmonary toxicity of multiwalled carbon nanotubes (MWCNTs), such as inflammation, interstitial fibrosis, granuloma formation, and carcinogenicity. Although numerous studies explored the adverse pote...
Animals Male Lung Mice Biomarkers Bronchoalveolar Lavage Fluid Support Vector Machine Mice, Inbred C57BL Nanotubes, Carbon
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A Machine Learning Approach to Automated Gait Analysis for the Noldus Catwalk System.

IEEE transactions on bio-medical engineering Aug 24, 2017
OBJECTIVE: Gait analysis of animal disease models can provide valuable insights into in vivo compound effects and thus help in preclinical drug development. The purpose of this paper is to establish a computational gait analysis approach for the Nold...
Walking Gait Parkinsonian Disorders Pattern Recognition, Automated Mice Disease Models, Animal Mice, Inbred C57BL Signal Processing, Computer-Assisted Gait Analysis Foot Oxidopamine Machine Learning Female Animals Male
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Identification of non-activated lymphocytes using three-dimensional refractive index tomography and machine learning.

Scientific reports Jul 27, 2017
Identification of lymphocyte cell types are crucial for understanding their pathophysiological roles in human diseases. Current methods for discriminating lymphocyte cell types primarily rely on labelling techniques with magnetic beads or fluorescenc...
Animals Lymphocyte Activation Single-Cell Analysis Mice Machine Learning Mice, Inbred C57BL Lymphocytes Refractometry Tomography
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Automated gesture tracking in head-fixed mice.

Journal of neuroscience methods Jul 17, 2017
BACKGROUND: The preparation consisting of a head-fixed mouse on a spherical or cylindrical treadmill offers unique advantages in a variety of experimental contexts. Head fixation provides the mechanical stability necessary for optical and electrophys...
Head Behavior, Animal Locomotion Behavioral Research Mice Mice, Inbred C57BL Supervised Machine Learning Image Interpretation, Computer-Assisted Animals Male Gestures
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