AIMC Topic: Mice, Inbred C57BL
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From Genes to Metabolites: HSP90B1's Role in Alzheimer's Disease and Potential for Therapeutic Intervention.
Neuromolecular medicine
Jan 6, 2025
Alzheimer's disease (AD) is a prototypical neurodegenerative disorder, predominantly affecting individuals in the presenile and elderly populations, with an etiology that remains elusive. This investigation aimed to elucidate the alterations in anoik...
Deciphering the cellular and molecular landscape of pulmonary fibrosis through single-cell sequencing and machine learning.
Journal of translational medicine
Jan 2, 2025
Pulmonary fibrosis is characterized by progressive lung scarring, leading to a decline in lung function and an increase in morbidity and mortality. This study leverages single-cell sequencing and machine learning to unravel the complex cellular and m...
A data-driven approach to establishing cell motility patterns as predictors of macrophage subtypes and their relation to cell morphology.
PloS one
Dec 31, 2024
The motility of macrophages in response to microenvironment stimuli is a hallmark of innate immunity, where macrophages play pro-inflammatory or pro-reparatory roles depending on their activation status during wound healing. Cell size and shape have ...
Machine learning and confirmatory factor analysis show that buprenorphine alters motor and anxiety-like behaviors in male, female, and obese C57BL/6J mice.
Journal of neurophysiology
Dec 30, 2024
Buprenorphine is an opioid approved for medication-assisted treatment of opioid use disorder. Used off-label, buprenorphine has been reported to contribute to the clinical management of anxiety. Although human anxiety is a highly prevalent disorder, ...
Application of deep learning models on single-cell RNA sequencing analysis uncovers novel markers of double negative T cells.
Scientific reports
Dec 28, 2024
Double negative T (DNT) cells are a unique subset of CD3 + TCRαβ + T lymphocytes that lack CD4, CD8, or NK1.1 expression and constitute 3-5% of the total T cell population in C57BL/6 mice. They have increasingly gained recognition for their novel rol...
Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse model.
Chinese medical journal
Dec 23, 2024
BACKGROUND: Retinal ganglion cell (RGC) death caused by acute ocular hypertension is an important characteristic of acute glaucoma. Receptor-interacting protein kinase 3 (RIPK3) that mediates necroptosis is a potential therapeutic target for RGC deat...
Integrating machine learning with bioinformatics for predicting idiopathic pulmonary fibrosis prognosis: developing an individualized clinical prediction tool.
Experimental biology and medicine (Maywood, N.J.)
Dec 23, 2024
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with a poor prognosis. Its non-specific clinical symptoms make accurate prediction of disease progression challenging. This study aimed to develop molecular-level prognostic m...
Identification and experimental validation of diagnostic and prognostic genes CX3CR1, PID1 and PTGDS in sepsis and ARDS using bulk and single-cell transcriptomic analysis and machine learning.
Frontiers in immunology
Dec 23, 2024
BACKGROUND: Sepsis is an uncontrolled reaction to infection that causes severe organ dysfunction and is a primary cause of ARDS. Patients suffering both sepsis and ARDS have a poor prognosis and high mortality. However, the mechanisms behind their si...
Enhancing automatic sleep stage classification with cerebellar EEG and machine learning techniques.
Computers in biology and medicine
Dec 10, 2024
Sleep disorders have become a significant health concern in modern society. To investigate and diagnose sleep disorders, sleep analysis has emerged as the primary research method. Conventional polysomnography primarily relies on cerebral electroencep...
Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation.
Neurobiology of disease
Dec 8, 2024
BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a high social burden and limited treatments. Hypoxic condition of the brain is considered an important pathological mechanism of ASD. HIF1A is a key participant in brain...
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