AIMC Topic: Mice, Transgenic

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A Novel Morphological Marker for the Analysis of Molecular Activities at the Single-cell Level.

Cell structure and function Jun 29, 2018
For more than a century, hematoxylin and eosin (H&E) staining has been the de facto standard for histological studies. Consequently, the legacy of histological knowledge is largely based on H&E staining. Due to the recent advent of multi-photon excit...
Mice, Inbred C57BL Microscopy, Fluorescence Dogs Madin Darby Canine Kidney Cells Mice, Transgenic Fluorescence Resonance Energy Transfer MAP Kinase Signaling System Animals Single-Cell Analysis Imaging, Three-Dimensional Biosensing Techniques Machine Learning
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Fully automated, deep learning segmentation of oxygen-induced retinopathy images.

JCI insight Dec 21, 2017
Oxygen-induced retinopathy (OIR) is a widely used model to study ischemia-driven neovascularization (NV) in the retina and to serve in proof-of-concept studies in evaluating antiangiogenic drugs for ocular, as well as nonocular, diseases. The primary...
Mice, Inbred C57BL Deep Learning Oxygen Algorithms Retinal Neovascularization Image Processing, Computer-Assisted Observer Variation Microscopy, Confocal Female Mice, Transgenic Disease Models, Animal Animals Male
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and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.

The Journal of biological chemistry May 23, 2017
Tumor exomes provide comprehensive information on mutated, overexpressed genes and aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of particular interest are mutated tumor antigen T-cell epitopes, because neoepitope-s...
Antigens, Neoplasm Vaccines, Synthetic Membrane Proteins Neoplasm Proteins Reproducibility of Results Animals Computational Biology Cancer Vaccines Protein Stability Expert Systems Oligopeptides Immunogenicity, Vaccine Mice, Transgenic Mice, Knockout Peptide Fragments Epitopes HLA-A2 Antigen Artificial Intelligence Cells, Cultured Melanoma Humans Models, Immunological Protein Refolding T-Lymphocytes, Cytotoxic
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Contralateral artery enlargement predicts carotid plaque progression based on machine learning algorithm models in apoE mice.

Biomedical engineering online Dec 28, 2016
BACKGROUND: This study specifically focused on anatomical MRI characterization of the low shear stress-induced atherosclerotic plaque in mice. We used machine learning algorithms to analyze multiple correlation factors of plaque to generate predictiv...
Mice Algorithms Support Vector Machine Machine Learning Reproducibility of Results Carotid Arteries Decision Making Animals Magnetic Resonance Imaging Blood Flow Velocity Sensitivity and Specificity Plaque, Atherosclerotic Mice, Inbred C57BL Mice, Transgenic Lipids Apolipoproteins E Male Predictive Value of Tests Disease Progression Ultrasonography, Doppler Ultrasonography
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Metaplasticity and continual learning: mechanisms subserving brain computer interface proficiency.

Journal of neural engineering May 23, 2025
Brain computer interfaces (BCIs) require substantial cognitive flexibility to optimize control performance. Remarkably, learning this control is rapid, suggesting it might be mediated by neuroplasticity mechanisms operating on very short time scales....
Mice, Transgenic Optogenetics Neuronal Plasticity Models, Neurological Mice, Inbred C57BL Brain-Computer Interfaces Learning Animals Male Mice
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Forestwalk: A Machine Learning Workflow Brings New Insights Into Posture and Balance in Rodent Beam Walking.

The European journal of neuroscience Mar 1, 2025
The beam walk is widely used to study coordination and balance in rodents. While the task has ethological validity, the main endpoints of "foot slip counts" and "time to cross" are prone to human-rater variability and offer limited sensitivity and sp...
Machine Learning Mice, Inbred C57BL Postural Balance Workflow Walking Mice, Transgenic Animals Male Mice Posture
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Machine Learning-Supported Analyses Improve Quantitative Histological Assessments of Amyloid-β Deposits and Activated Microglia.

Journal of Alzheimer's disease : JAD Jan 1, 2021
BACKGROUND: Detailed pathology analysis and morphological quantification is tedious and prone to errors. Automatic image analysis can help to increase objectivity and reduce time. Here, we present the evaluation of the DeePathology STUDIO™ for automa...
Alzheimer Disease Mice, Transgenic Plaque, Amyloid Machine Learning Image Processing, Computer-Assisted Animals Mice Disease Models, Animal Microglia
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Complementary feature selection from alternative splicing events and gene expression for phenotype prediction.

Bioinformatics (Oxford, England) Sep 1, 2016
MOTIVATION: A central task of bioinformatics is to develop sensitive and specific means of providing medical prognoses from biomarker patterns. Common methods to predict phenotypes in RNA-Seq datasets utilize machine learning algorithms trained via g...
Lung Neoplasms Carcinoma, Non-Small-Cell Lung Amyotrophic Lateral Sclerosis Mice, Transgenic Alternative Splicing Algorithms Phenotype Pulmonary Disease, Chronic Obstructive Animals Humans Machine Learning
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Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.

Advances in experimental medicine and biology Jan 1, 2016
High content analysis (HCA) has become a leading methodology in phenotypic drug discovery efforts. Typical HCA workflows include imaging cells using an automated microscope and analyzing the data using algorithms designed to quantify one or more spec...
Phosphotransferases Photoreceptor Cells, Vertebrate Animals Computational Biology Enzyme Inhibitors Machine Learning Neurites Algorithms Small Molecule Libraries Cells, Cultured Green Fluorescent Proteins Primary Cell Culture Reproducibility of Results Mice, Transgenic Cell Tracking
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Mapping Sub-Second Structure in Mouse Behavior.

Neuron Dec 16, 2015
Complex animal behaviors are likely built from simpler modules, but their systematic identification in mammals remains a significant challenge. Here we use depth imaging to show that 3D mouse pose dynamics are structured at the sub-second timescale. ...
Machine Learning Computer Simulation Imaging, Three-Dimensional Mice Mice, Inbred C57BL Animals Male Behavior, Animal Mice, Transgenic Optogenetics Kinesics
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