AIMC Topic: Mice

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Anticancer and anti-inflammatory activities of girinimbine isolated from .

Drug design, development and therapy Dec 28, 2016
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a...
Zebrafish Alkaloids HT29 Cells Tumor Cells, Cultured Antineoplastic Agents, Phytogenic Drug Screening Assays, Antitumor Structure-Activity Relationship Anti-Inflammatory Agents, Non-Steroidal Murraya Cytokines Animals Mice Nitric Oxide Lipopolysaccharides Dose-Response Relationship, Drug Cell Survival Cell Proliferation Apoptosis Humans
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Contralateral artery enlargement predicts carotid plaque progression based on machine learning algorithm models in apoE mice.

Biomedical engineering online Dec 28, 2016
BACKGROUND: This study specifically focused on anatomical MRI characterization of the low shear stress-induced atherosclerotic plaque in mice. We used machine learning algorithms to analyze multiple correlation factors of plaque to generate predictiv...
Algorithms Reproducibility of Results Sensitivity and Specificity Animals Ultrasonography Blood Flow Velocity Predictive Value of Tests Mice Mice, Transgenic Ultrasonography, Doppler Support Vector Machine Apolipoproteins E Carotid Arteries Magnetic Resonance Imaging Male Plaque, Atherosclerotic Mice, Inbred C57BL Machine Learning Disease Progression Decision Making Lipids
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The injury of serotonin on intestinal epithelium cell renewal of weaned diarrhoea mice.

European journal of histochemistry : EJH Dec 28, 2016
Diarrhoea is a common cause of death in children and weaned animals. Recent research has found that serotonin (5-HT) in the gastrointestinal tract plays an important role in regulating growth and the maintenance of mucosa, which protect against diarr...
Mice Disease Models, Animal Apoptosis Intestinal Mucosa Mice, Inbred ICR Animals Male Diarrhea Intestine, Small Serotonin Senna Extract
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An LC-MS/MS method for the determination of digitoxigenin in skin samples and its application to skin permeation and metabolic stability studies.

Journal of pharmaceutical and biomedical analysis Dec 23, 2016
An LC-MS/MS method was developed for the determination of digitoxigenin in mice skin samples. Chromatographic separation was achieved on an Agilent Poroshell 120 EC-C18 column. Mass spectrometric detection was achieved by a triple-quadrupole mass spe...
Drug Stability Calibration Reproducibility of Results Chromatography, Liquid Digitoxigenin Swine Skin Tandem Mass Spectrometry Mice Permeability Mice, Inbred C57BL Sensitivity and Specificity Animals
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Anticancer activity of biologically synthesized silver and gold nanoparticles on mouse myoblast cancer cells and their toxicity against embryonic zebrafish.

Materials science & engineering. C, Materials for biological applications Dec 23, 2016
The aim of this study was to evaluate the anticancer activity of bioinspired silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) against mouse myoblast cancer cells (CC). Both AgNPs and AuNPs were biologically synthesized using Spinacia olera...
Myoblasts Toxicity Tests X-Ray Diffraction Embryo, Nonmammalian Metal Nanoparticles Cell Line, Tumor Silver Mice Zebrafish Staining and Labeling Caspases Apoptosis Animals Plant Extracts Spinacia oleracea Cell Survival Antineoplastic Agents Acridine Orange Plant Leaves Gold Cell Shape Ethidium Photoacoustic Techniques
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Interspecies gene function prediction using semantic similarity.

BMC systems biology Dec 23, 2016
BACKGROUND: Gene Ontology (GO) is a collaborative project that maintains and develops controlled vocabulary (or terms) to describe the molecular function, biological roles and cellular location of gene products in a hierarchical ontology. GO also pro...
Natural Language Processing Zebrafish Semantics Saccharomyces cerevisiae Gene Ontology Animals Species Specificity Humans Mice Molecular Sequence Annotation Computational Biology Databases, Genetic
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Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit.

eLife Dec 23, 2016
The hippocampal theta rhythm plays important roles in information processing; however, the mechanisms of its generation are not well understood. We developed a data-driven, supercomputer-based, full-scale (1:1) model of the rodent CA1 area and studie...
Neuroglia Spatio-Temporal Analysis Mice Interneurons Neural Networks, Computer Rats Theta Rhythm CA1 Region, Hippocampal Animals
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Icariin improves eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null mice.

Canadian journal of physiology and pharmacology Dec 22, 2016
Impaired endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway induces atherogenesis. The present study examined whether icariin improves the eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null (ApoE) mice. In vitro, p...
Apolipoproteins E Gene Deletion Nitric Oxide Synthase Type III Mice, Inbred C57BL Humans Flavonoids Animals Atherosclerosis Mice Gene Expression Regulation, Enzymologic Nitric Oxide
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Phenolic constituents of Pulicaria undulata (L.) C.A. Mey. sub sp. undulata (Asteraceae): Antioxidant protective effects and chemosystematic significances.

Journal of food and drug analysis Dec 22, 2016
One new naturally isoflavone compound, 5,7,2',3',4' penta hydroxyl isoflavone-4'-O-β-glucopyranoside (1) was isolated from the aqueous methanol extract (AME) of Pulicaria undulata subsp. undulata, together with seven known compounds: kaempferol (2), ...
Picrates Animals Pulicaria Mice Antioxidants Biphenyl Compounds
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Dendritic spine classification using shape and appearance features based on two-photon microscopy.

Journal of neuroscience methods Dec 18, 2016
BACKGROUND: Neuronal morphology and function are highly coupled. In particular, dendritic spine morphology is strongly governed by the incoming neuronal activity. The first step towards understanding the structure-function relationships is to classif...
Machine Learning Data Interpretation, Statistical Hippocampus Pattern Recognition, Automated Tissue Culture Techniques Dendritic Spines Animals Imaging, Three-Dimensional Mice Microscopy, Confocal
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