FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dec 15, 2025
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease in which endothelial cell senescence (ECS) plays a key role. By integrating two GEO transcriptome datasets (145 IPF patients and 84 controls) and applying LASSO, SVM-RFE, ...
SIGNIFICANCE: Molecular photoacoustic (PA) imaging with exogenous dyes faces a significant challenge due to the photobleaching of the dye that can compromise tissue visualization, particularly in 3D imaging. Addressing this limitation can revolutioni...
OBJECTIVE: Diagnosis of hepatocellular carcinoma (HCC) remains challenging for clinicians. Machine learning approaches and big data analyses are viable strategies for identifying HCC diagnostic markers.
IEEE transactions on bio-medical engineering
Dec 1, 2025
Chemical Exchange Saturation Transfer (CEST) MRI has demonstrated its remarkable ability to enhance the detection of macromolecules and metabolites with low concentrations. While CEST mapping is essential for quantifying molecular information, conven...
Therapeutic monoclonal antibodies (mAbs) are a successful class of biologic drugs that are frequently selected from phage display libraries and transgenic mice that produce fully human antibodies. However, binding affinity to the correct epitope is n...
Regulating inflammatory microglia presents a promising strategy for treating neurodegenerative and autoimmune disorders, yet effective therapeutic agents delivery to these cells remains a challenge. This study investigates modified lipid nanoparticle...
BACKGROUND: Renal fibrosis is a critical factor in chronic kidney disease progression, with limited diagnostic and therapeutic options. Emerging evidence suggests RNA-binding proteins (RBPs) are pivotal in regulating cellular mechanisms underlying fi...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Nov 30, 2025
Machine learning was employed to annotate images of the thoracic aorta, resulting in the identification of additional thoracic-related targets. However, genetic evaluation of the associations among thoracic aortic traits and their shared genes is lac...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Nov 5, 2025
Myocardial hypertrophy and heart failure are leading causes of mortality in cardiovascular diseases, yet current diagnostic techniques lack the resolution to monitor molecular changes effectively. In this study, we employed confocal Raman spectroscop...
Terahertz (THz) optical sensing and imaging offer significant potential in a range of biological and medical applications owing to their low-energy, non-ionizing nature, and ultra-broadband spectral information, which includes numerous molecular fing...
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