AIMC Topic: Mice

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Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics.

Nature methods Oct 14, 2019
We engineered light-gated channelrhodopsins (ChRs) whose current strength and light sensitivity enable minimally invasive neuronal circuit interrogation. Current ChR tools applied to the mammalian brain require intracranial surgery for transgene deli...
HEK293 Cells Protein Engineering Optogenetics Channelrhodopsins Machine Learning Animals Mice Mice, Inbred C57BL Humans
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Visual Correspondences for Unsupervised Domain Adaptation on Electron Microscopy Images.

IEEE transactions on medical imaging Oct 9, 2019
We present an Unsupervised Domain Adaptation strategy to compensate for domain shifts on Electron Microscopy volumes. Our method aggregates visual correspondences-motifs that are visually similar across different acquisitions-to infer changes on the ...
Algorithms Microscopy, Electron Mice Brain Unsupervised Machine Learning Animals Mitochondria Image Processing, Computer-Assisted
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Pathway-Based Single-Cell RNA-Seq Classification, Clustering, and Construction of Gene-Gene Interactions Networks Using Random Forests.

IEEE journal of biomedical and health informatics Oct 1, 2019
Single-cell RNA-Sequencing (scRNA-Seq), an advanced sequencing technique, enables biomedical researchers to characterize cell-specific gene expression profiles. Although studies have adapted machine learning algorithms to cluster different cell popul...
Machine Learning Algorithms Mice Cells, Cultured Cluster Analysis Animals Decision Trees Single-Cell Analysis Stem Cells RNA-Seq Gene Regulatory Networks
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Task-Dependent Changes in the Large-Scale Dynamics and Necessity of Cortical Regions.

Neuron Sep 26, 2019
Neural activity throughout the cortex is correlated with perceptual decisions, but inactivation studies suggest that only a small number of areas are necessary for these behaviors. Here we show that the number of required cortical areas and their dyn...
Mice, Inbred C57BL Decision Making Cerebral Cortex Animals Male Neural Networks, Computer Mice Female
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An in vitro assay and artificial intelligence approach to determine rate constants of nanomaterial-cell interactions.

Scientific reports Sep 26, 2019
In vitro assays and simulation technologies are powerful methodologies that can inform scientists of nanomaterial (NM) distribution and fate in humans or pre-clinical species. For small molecules, less animal data is often needed because there are a ...
Toxicity Tests Spectrophotometry Artificial Intelligence Cell Line Software Quantum Dots Animals Lysosomes Drug Discovery Cell Membrane Mice
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Phasic dopamine release identification using convolutional neural network.

Computers in biology and medicine Sep 25, 2019
Dopamine has a major behavioral impact related to drug dependence, learning and memory functions, as well as pathologies such as schizophrenia and Parkinson's disease. Phasic release of dopamine can be measured in vivo with fast-scan cyclic voltammet...
Rats Humans Brain Dopamine Rats, Sprague-Dawley Animals Neural Networks, Computer Electrodes, Implanted Electrochemical Techniques Male Databases, Factual Mice
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Sequential Saliency Guided Deep Neural Network for Joint Mitosis Identification and Localization in Time-Lapse Phase Contrast Microscopy Images.

IEEE journal of biomedical and health informatics Sep 23, 2019
The analysis of cell mitotic behavior plays important role in many biomedical research and medical diagnostic applications. To improve the accuracy of mitosis detection in automated analysis systems, this paper proposes the sequential saliency guided...
Mice Stem Cells Mitosis Microscopy, Phase-Contrast Time-Lapse Imaging Cells, Cultured Animals Deep Learning Image Processing, Computer-Assisted Neural Networks, Computer
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Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning.

Nature communications Sep 19, 2019
Highly specific Cas9 nucleases derived from SpCas9 are valuable tools for genome editing, but their wide applications are hampered by a lack of knowledge governing guide RNA (gRNA) activity. Here, we perform a genome-scale screen to measure gRNA acti...
Humans Base Sequence CRISPR-Cas Systems Clustered Regularly Interspaced Short Palindromic Repeats Animals Deep Learning Endonucleases Gene Editing Internet Cell Line, Tumor Promoter Regions, Genetic INDEL Mutation HeLa Cells Mice RNA, Guide, CRISPR-Cas Systems HEK293 Cells
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Three-dimensional convolutional neural networks for simultaneous dual-tracer PET imaging.

Physics in medicine and biology Sep 19, 2019
Dual-tracer positron emission tomography (PET) is a promising technique to measure the distribution of two tracers in the body by a single scan, which can improve the clinical accuracy of disease diagnosis and can also serve as a research tool for sc...
Algorithms Brain Tomography, X-Ray Computed Female Humans Neural Networks, Computer Image Processing, Computer-Assisted Mice Mice, Inbred BALB C Positron-Emission Tomography Animals Deep Learning Cell Line, Tumor Imaging, Three-Dimensional Monte Carlo Method Neoplasm Transplantation
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Neuromuscular actuation of biohybrid motile bots.

Proceedings of the National Academy of Sciences of the United States of America Sep 16, 2019
The integration of muscle cells with soft robotics in recent years has led to the development of biohybrid machines capable of untethered locomotion. A major frontier that currently remains unexplored is neuronal actuation and control of such muscle-...
Embryonic Stem Cells Coculture Techniques Muscle Contraction Hydrodynamics Movement Flagella Robotics Optogenetics Equipment Design Mice Motor Neurons Myoblasts Animals Cell Line Collagen Muscle, Skeletal
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