BACKGROUND: Prognostic tools for determining patients with indolent breast cancers (BCs) are far from optimal, leading to extensive overtreatment. Several studies have demonstrated mRNAs, lncRNAs and miRNAs to have prognostic potential in BC. Because...
An underlying association between primary open-angle glaucoma (POAG) and COVID-19 has been hypothesized, but the causal link and shared mechanisms remain unclear. This study integrates epidemiological and bioinformatics approaches to investigate thei...
This study aims to explore the association between anoikis-related genes (ARGs) and asthma. The dataset GSE143303 for asthma were sourced from the GEO database, while ARGs were retrieved from the Harmonizome web portal and the GeneCards database. Dif...
This study aimed to identify the potential pathogenic genes associated with the comorbidity of rheumatoid arthritis (RA) and renal fibrosis (RF). Transcriptomic data related to RA and RF were retrieved from the GEO database. Differential expression g...
Mitochondrial dysfunction is crucial in the pathogenesis and drug resistance of pediatric T-cell acute lymphoblastic leukemia (T-ALL), a malignant hematological disorder with unrestrained proliferation of immature T-cells. Therefore, the primary obje...
Acute myocardial infarction (AMI) poses a significant global mortality burden. Utilizing bio informatics, this study explored cellular aging-related genes (CARGs) and mitochondrial-related genes (MRGs). in AMI Public AMI datasets were analyzed using ...
PURPOSE: Pancreatic cancer (PC) is one of the most lethal malignancies, often presenting with nonspecific symptoms and a dismal prognosis. Despite advancements in treatments, the 5-year survival rate remains low, highlighting the urgent need for effe...
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Jun 30, 2025
BACKGROUND: Medulloblastoma (MB) is the most common malignant brain tumor in children. Current diagnostic methods, such as MRI and lumbar puncture, are invasive and not sensitive enough, making early diagnosis challenging. MicroRNAs (miRNAs) have eme...
BACKGROUND: Major depressive disorder (MDD) exhibits a multifactorial etiopathogenesis, yet current diagnosis still relies on clinician-rated symptom scales and phenomenological interviews, lacking validated biomarkers.
Through multi-faceted comparative analysis of MITEs across six pear genomes, we revealed their distribution patterns, functional impacts and their significant role as genomic origins for miRNAs, with copy number being the most critical factor for MIT...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.