AIMC Topic: Middle Aged

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Small, dense high-density lipoprotein 3 particles exhibit defective antioxidative and anti-inflammatory function in familial hypercholesterolemia: Partial correction by low-density lipoprotein apheresis.

Journal of clinical lipidology
BACKGROUND: Familial hypercholesterolemia (FH) features elevated oxidative stress and accelerated atherosclerosis driven by elevated levels of atherogenic lipoproteins relative to subnormal levels of atheroprotective high-density lipoprotein (HDL). S...

Pain Intensity Recognition Rates via Biopotential Feature Patterns with Support Vector Machines.

PloS one
BACKGROUND: The clinically used methods of pain diagnosis do not allow for objective and robust measurement, and physicians must rely on the patient's report on the pain sensation. Verbal scales, visual analog scales (VAS) or numeric rating scales (N...

Estimation of ground reaction forces and ankle moment with multiple, low-cost sensors.

Journal of neuroengineering and rehabilitation
BACKGROUND: Wearable sensor systems can provide data for at-home gait analyses and input to controllers for rehabilitation devices but they often have reduced estimation accuracy compared to laboratory systems. The goal of this study is to evaluate a...

Prediction of delayed graft function after kidney transplantation: comparison between logistic regression and machine learning methods.

BMC medical informatics and decision making
BACKGROUND: Predictive models for delayed graft function (DGF) after kidney transplantation are usually developed using logistic regression. We want to evaluate the value of machine learning methods in the prediction of DGF.

The advantages of combination therapy on hypertension: development of immediate release perindopril-indapamide tablet and assessment of bioequivalence studies.

Pharmaceutical development and technology
Hypertension has a major associated risk for organ damage and mortality, which is further heightened in patients with prior cardiovascular events, comorbid diabetes mellitus, microalbuminuria and renal impairment. Convers Plus tablet including perind...

Opinion versus practice regarding the use of rehabilitation services in home care: an investigation using machine learning algorithms.

BMC medical informatics and decision making
BACKGROUND: Resources for home care rehabilitation are limited, and many home care clients who could benefit do not receive rehabilitation therapy. The interRAI Contact Assessment (CA) is a new screening instrument comprised of a subset of interRAI H...

Feasibility study into self-administered training at home using an arm and hand device with motivational gaming environment in chronic stroke.

Journal of neuroengineering and rehabilitation
BACKGROUND: Assistive and robotic training devices are increasingly used for rehabilitation of the hemiparetic arm after stroke, although applications for the wrist and hand are trailing behind. Furthermore, applying a training device in domestic set...

Long-term Effectiveness of Intensive Therapy in Chronic Stroke.

Neurorehabilitation and neural repair
Background While recent clinical trials involving robot-assisted therapy have failed to show clinically significant improvement versus conventional therapy, it is possible that a broader strategy of intensive therapy-to include robot-assisted rehabil...

Real alerts and artifact classification in archived multi-signal vital sign monitoring data: implications for mining big data.

Journal of clinical monitoring and computing
Huge hospital information system databases can be mined for knowledge discovery and decision support, but artifact in stored non-invasive vital sign (VS) high-frequency data streams limits its use. We used machine-learning (ML) algorithms trained on ...