AIMC Topic: Middle Aged

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Boi-Ogi-To, a Traditional Japanese Kampo Medicine, Promotes Cellular Excretion of Chloride and Water by Activating Volume-Sensitive Outwardly Rectifying Anion Channels.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
The Japanese Kampo medicine Boi-ogi-to (BOT) is known as an effective therapeutic agent for edema and nephrosis by promoting the excretion of excess body fluids. Despite its empirical effectiveness, scientific evidence supporting its effectiveness re...

Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research
PURPOSE: The Cancer Genome Atlas (TCGA) project defined four distinct molecular subtypes of esophagogastric adenocarcinoma: microsatellite instable (MSI), Epstein-Barr virus (EBV)-associated, genomically stable (GS), and chromosomally instable (CIN)....

Protein Profiles Predict Treatment Responses to the PI3K Inhibitor Umbralisib in Patients with Chronic Lymphocytic Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research
PURPOSE: The management of chronic lymphocytic leukemia (CLL) has significantly improved with targeted therapies. However, many patients experience a suboptimal response. To optimally select the best therapy, predictive biomarkers are necessary. In t...

A machine-learning-derived online prediction model for depression risk in COPD patients: A retrospective cohort study from CHARLS.

Journal of affective disorders
BACKGROUND: Depression associated with Chronic Obstructive Pulmonary Disease (COPD) is a detrimental complication that significantly impairs patients' quality of life. This study aims to develop an online predictive model to estimate the risk of depr...

Machine learning-based prognostic subgrouping of glioblastoma: A multicenter study.

Neuro-oncology
BACKGROUND: Glioblastoma (GBM) is the most aggressive adult primary brain cancer, characterized by significant heterogeneity, posing challenges for patient management, treatment planning, and clinical trial stratification.

Machine learning prediction model of prolonged delay to loop ileostomy closure after rectal cancer surgery: a retrospective study.

World journal of surgical oncology
BACKGROUND: Delayed closure of a temporary ileostomy in patients with rectal cancer may cause psychological, physiological, and socioeconomic burdens to patients.

Optimizing breast lesions diagnosis and decision-making with a deep learning fusion model integrating ultrasound and mammography: a dual-center retrospective study.

Breast cancer research : BCR
BACKGROUND: This study aimed to develop a BI-RADS network (DL-UM) via integrating ultrasound (US) and mammography (MG) images and explore its performance in improving breast lesion diagnosis and management when collaborating with radiologists, partic...

Prognostic value of circadian rhythm-associated genes in breast cancer.

World journal of surgical oncology
OBJECTIVE: Breast cancer (BC) remains the most prevalent malignancy among women. Clinical evidence indicates that genetic variations related to circadian rhythms, as well as the timing of therapeutic interventions, influence the response to radiation...

Development and application of an early prediction model for risk of bloodstream infection based on real-world study.

BMC medical informatics and decision making
BACKGROUND: Bloodstream Infection (BSI) is a severe systemic infectious disease that can lead to sepsis and Multiple Organ Dysfunction Syndrome (MODS), resulting in high mortality rates and posing a major public health burden globally. Early identifi...