AIMC Topic: Paclitaxel

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Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning.

Molecular oncology Aug 22, 2015
Increasingly, the effectiveness of adjuvant chemotherapy agents for breast cancer has been related to changes in the genomic profile of tumors. We investigated correspondence between growth inhibitory concentrations of paclitaxel and gemcitabine (GI5...
Antineoplastic Agents Cell Line, Tumor Female Breast Neoplasms Drug Resistance, Neoplasm Deoxycytidine Gemcitabine Support Vector Machine Paclitaxel Humans Machine Learning
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Unraveling the molecular mechanisms of paclitaxel in high-grade serous ovarian cancer through network pharmacology.

Scientific reports May 12, 2025
High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of epithelial ovarian cancer, often diagnosed at advanced stages with a poor prognosis. Paclitaxel (PTX), a standard chemotherapeutic agent for HGSOC, exerts cytotoxic...
Female Tumor Microenvironment Humans Prognosis Protein Interaction Maps Gene Regulatory Networks Computational Biology Biomarkers, Tumor Molecular Docking Simulation Kaplan-Meier Estimate Cystadenocarcinoma, Serous Network Pharmacology Ovarian Neoplasms Paclitaxel Gene Expression Regulation, Neoplastic Antineoplastic Agents, Phytogenic
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Efficacy and safety of carboplatin with nab-paclitaxel versus docetaxel in older patients with squamous non-small-cell lung cancer (CAPITAL): a randomised, multicentre, open-label, phase 3 trial.

The lancet. Healthy longevity Dec 1, 2021
BACKGROUND: In Japan, docetaxel, a cytotoxic monotherapy, is the standard drug administered to older patients with advanced non-small-cell lung cancer (NSCLC). Carboplatin plus nab-paclitaxel has shown a high objective response rate in patients with ...
Leukopenia Paclitaxel Carboplatin Docetaxel Lung Neoplasms Antineoplastic Combined Chemotherapy Protocols Carcinoma, Non-Small-Cell Lung Albumins Aged Aged, 80 and over Humans Carcinoma, Squamous Cell
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[A Case of Breast Cancer Liver Metastases with Jaundice Responding to Chemotherapy].

Gan to kagaku ryoho. Cancer & chemotherapy Dec 1, 2019
A 50-year-old woman was referred to our hospital due to breast cancer with multiple liver metastasis diagnosed by CT scan. Laboratory findings showed liver dysfunction(T-Bil 7.6mg/dL)with marked elevation of tumor markers(CEA 727.9 ng/mL). Breast tum...
Carcinoma, Ductal, Breast Jaundice Antineoplastic Combined Chemotherapy Protocols Paclitaxel Breast Neoplasms Middle Aged Liver Neoplasms Humans Female
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A comparative phase III clinical study to evaluate efficacy and safety of TrastuRel™ (biosimilar trastuzumab) and innovator trastuzumab in patients with metastatic human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer.

Indian journal of cancer Jan 1, 2017
INTRODUCTION: The present study for biosimilar trastuzumab was a multicentric, randomized, two-arm parallel-group, comparative phase III study in patients with metastatic breast cancer.
Trastuzumab Biosimilar Pharmaceuticals Drug-Related Side Effects and Adverse Reactions Adult Disease-Free Survival Aged Breast Neoplasms Receptor, ErbB-2 Antineoplastic Combined Chemotherapy Protocols Middle Aged Paclitaxel Remission Induction India Humans Female
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Paclitaxel-loaded niosomes for intravenous administration: pharmacokinetics and tissue distribution in rats.

Turkish journal of medical sciences Jan 1, 2015
BACKGROUND/AIM: The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, after intravenous injection to rats.
Injections, Intravenous Chromatography, High Pressure Liquid Liposomes Tissue Distribution Paclitaxel Rats, Wistar Antineoplastic Agents, Phytogenic Animals
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