AIMC Topic: Predictive Value of Tests

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Circulating long non-coding RNAs as predictors of type 2 diabetes mellitus development: results from the CORDIOPREV study.

Cardiovascular diabetology
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a growing global health challenge. Conventional diagnostic tools have limited sensitivity and specificity for early-stage disease. In this context, long non-coding RNAs (lncRNAs) have emerged as promisin...

Both Infarcted and Noninfarcted Brain Regions Contribute to Deep Learning-Based MRI Prediction of Acute Stroke Outcome.

AJNR. American journal of neuroradiology
BACKGROUND AND PURPOSE: Predicting long-term clinical outcomes based on early acute ischemic stroke (AIS) information would be useful for many reasons, including patient counseling and clinical trial execution. This study investigates how different r...

Radiomics-based MRI models for predicting breast cancer axillary lymph node involvement in comparison with Node-RADS: a proof-of-concept study.

European radiology experimental
BACKGROUND: Detection of axillary lymph node (LN) involvement is essential for staging breast cancer and optimizing treatment. This proof-of-concept two-center study explored the feasibility of magnetic resonance imaging (MRI) radiomics-based machine...

Plasma metabolomics disentangles T2DM- and CAD-specific dysmetabolism and identifies potential biomarkers for CAD risk escalation in diabetic patients.

Cardiovascular diabetology
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major driver of coronary artery disease (CAD). Prior studies often conflate T2DM- and CAD-specific metabolic alterations, limiting insights into CAD pathogenesis in T2DM. This study aimed to distinguis...

C-reactive protein-triglyceride glucose index in predicting three-vessel coronary artery disease risk: a retrospective study using machine learning approaches.

Annals of medicine
BACKGROUND: Three-vessel coronary artery disease (TVD) is a severe subtype of coronary heart disease, strongly associated with inflammation and metabolic dysfunction. The C-reactive protein-triglyceride glucose index (CTI), an integrated measure of i...

Precision integrated identification of predictive first-trimester metabolomics signatures for early detection of gestational diabetes mellitus.

Cardiovascular diabetology
BACKGROUND AND AIM: Gestational diabetes mellitus (GDM), a common pregnancy-related metabolic disorder, often goes undiagnosed until the second trimester, limiting early intervention opportunities. Given the higher prevalence of GDM in India, there i...