OBJECTIVE: Ulcerative colitis (UC) is a chronic inflammatory bowel disease for which remission is dependent on corticosteroid (CS) treatment. The diversity of disease pathophysiology necessitates optimal case-specific treatment selection. This study ...
BACKGROUND: Gastric cancer (GC) is a highly heterogeneous disease, and the response of patients to clinical treatment varies substantially. There is no satisfactory strategy for predicting curative effects to date. We aimed to explore a new method fo...
BACKGROUND: Little is known about acute kidney injury (AKI) and acute kidney disease (AKD) in patients with chronic obstructive pulmonary disease (COPD) and COPD mortality based on the acute/subacute renal injury. This study develops machine learning...
OBJECTIVE: We aimed at identifying acute phase biomarkers in Severe Fever with Thrombocytopenia Syndrome (SFTS), and to establish a model to predict mortality outcomes.
Artificial cells, nanomedicine, and biotechnology
Dec 1, 2025
Gastric cancer remains one of the deadliest cancers globally due to delayed detection and limited treatment options, underscoring the critical need for innovative prognostic methods. Disulfidptosis, a recently discovered programmed cell death trigger...
BACKGROUND: Juvenile idiopathic arthritis (JIA), superseding juvenile rheumatoid arthritis (JRA), is a chronic autoimmune disease affecting children and characterized by various types of childhood arthritis. JIA manifests clinically with joint inflam...
Acute myeloid leukemia (AML) is characterized by a low 5-year survival rate. Despite having many clinical metrics to assess patient prognosis, there remain opportunities to improve risk stratification. We hypothesized that an underexplored resource t...
BACKGROUND: Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and fetal mortality worldwide. Early detection and risk stratification are critical for timely intervention to prevent severe complications such as eclampsia, strok...
The face, being central and exposed, is highly susceptible to trauma and subsequent scar formation. Laser therapy is a common and effective treatment method for facial scars. However, treatment outcomes vary substantially. Consequently, we aimed to i...
Clinical cancer research : an official journal of the American Association for Cancer Research
Nov 14, 2025
PURPOSE: Treatment with immune checkpoint inhibitors (ICI) in advanced melanoma can result in durable responses, yet an algorithm to decide which patients can safely discontinue ICI is still lacking.
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