AIMC Topic: Signal Transduction

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Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice.

Journal of food and drug analysis Apr 19, 2017
Cinnamomum osmophloeum Kanehira is a Taiwan native plant that belongs to genus Cinnamomum and is also known as pseudocinnamomum or indigenous cinnamon. Its leaf is traditionally used by local people in cooking and as folk therapy. We previously demon...
Endotoxins Male Inflammation Anti-Inflammatory Agents Humans Oils, Volatile Signal Transduction Cytokines NLR Family, Pyrin Domain-Containing 3 Protein Mice Plant Leaves Biomarkers Inflammation Mediators Plant Extracts NF-kappa B Animals Acrolein Cinnamomum
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Sensitive detection of rare disease-associated cell subsets via representation learning.

Nature communications Apr 6, 2017
Rare cell populations play a pivotal role in the initiation and progression of diseases such as cancer. However, the identification of such subpopulations remains a difficult task. This work describes CellCnn, a representation learning approach to de...
Rare Diseases Neoplasm, Residual Leukemia Immunologic Memory Single-Cell Analysis Monocytes Signal Transduction Acquired Immunodeficiency Syndrome Cytomegalovirus Infections Supervised Machine Learning Humans Survival Analysis Neural Networks, Computer Killer Cells, Natural Cytokines T-Lymphocyte Subsets Prognosis
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Identification of transcription factors that may reprogram lung adenocarcinoma.

Artificial intelligence in medicine Apr 1, 2017
BACKGROUND: Lung adenocarcinoma is one of most threatening disease to human health. Although many efforts have been devoted to its genetic study, few researches have been focused on the transcription factors which regulate tumor initiation and progre...
Humans Artificial Intelligence Gene Regulatory Networks Lung Neoplasms Computational Biology Adenocarcinoma Databases, Genetic Cell Transformation, Neoplastic Transcription, Genetic Adenocarcinoma of Lung Epigenesis, Genetic Gene Expression Regulation, Neoplastic Signal Transduction Transcription Factors
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Computational methods using genome-wide association studies to predict radiotherapy complications and to identify correlative molecular processes.

Scientific reports Feb 24, 2017
The biological cause of clinically observed variability of normal tissue damage following radiotherapy is poorly understood. We hypothesized that machine/statistical learning methods using single nucleotide polymorphism (SNP)-based genome-wide associ...
Polymorphism, Single Nucleotide Gene Expression Regulation, Neoplastic Signal Transduction Neoplasm Proteins Prostatic Neoplasms Male Middle Aged Genome-Wide Association Study Cohort Studies Radiation Tolerance Gamma Rays Prostate Rectum Hemorrhage Erectile Dysfunction Humans Machine Learning Prognosis Aged Biomarkers, Tumor
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Analysis of cancer-related lncRNAs using gene ontology and KEGG pathways.

Artificial intelligence in medicine Feb 13, 2017
BACKGROUND: Cancer is a disease that involves abnormal cell growth and can invade or metastasize to other tissues. It is known that several factors are related to its initiation, proliferation, and invasiveness. Recently, it has been reported that lo...
Computational Biology Signal Transduction RNA, Long Noncoding Gene Ontology Humans Neoplasms
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A system of recurrent neural networks for modularising, parameterising and dynamic analysis of cell signalling networks.

Bio Systems Feb 4, 2017
In this paper, we show how to extend our previously proposed novel continuous time Recurrent Neural Networks (RNN) approach that retains the advantage of continuous dynamics offered by Ordinary Differential Equations (ODE) while enabling parameter es...
Humans Neural Networks, Computer Reproducibility of Results Cell Cycle Feedback Animals Signal Transduction Models, Biological
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Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.

The Kaohsiung journal of medical sciences Dec 30, 2016
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
Chondrocytes Saponins Tumor Suppressor Protein p53 Gene Expression Regulation Proliferating Cell Nuclear Antigen Cyclooxygenase 2 Cartilage, Articular Matrix Metalloproteinase 3 Primary Cell Culture Male Plant Roots Plant Extracts Interleukin-1beta Achyranthes Rats NF-kappa B bcl-Associated Death Protein Inflammation Matrix Metalloproteinase 9 bcl-X Protein Signal Transduction bcl-2-Associated X Protein Rats, Sprague-Dawley Apoptosis Animals Caspase 3 Anti-Inflammatory Agents, Non-Steroidal
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Basic fibroblast growth factor is critical to reprogramming buffalo (Bubalus bubalis) primordial germ cells into embryonic germ stem cell-like cells.

Theriogenology Dec 29, 2016
Primordial germ cells (PGCs) are destined to form gametes in vivo, and they can be reprogrammed into pluripotent embryonic germ (EG) cells in vitro. Buffalo PGC have been reported to be reprogrammed into EG-like cells, but the identities of the major...
Cell Differentiation Fibroblast Growth Factors Buffaloes MAP Kinase Signaling System Animals Cell Lineage Cell Culture Techniques Signal Transduction Embryonic Germ Cells Cellular Reprogramming Pluripotent Stem Cells
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Identification of DEP domain-containing proteins by a machine learning method and experimental analysis of their expression in human HCC tissues.

Scientific reports Dec 21, 2016
The Dishevelled/EGL-10/Pleckstrin (DEP) domain-containing (DEPDC) proteins have seven members. However, whether this superfamily can be distinguished from other proteins based only on the amino acid sequences, remains unknown. Here, we describe a com...
GTPase-Activating Proteins Algorithms Dishevelled Proteins Humans Phylogeny Signal Transduction Machine Learning Gene Expression Profiling Cluster Analysis Real-Time Polymerase Chain Reaction Liver Neoplasms Protein Domains Carcinoma, Hepatocellular Amino Acid Motifs Computational Biology RNA, Messenger Gene Expression Regulation, Neoplastic
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Spatial dispersal of bacterial colonies induces a dynamical transition from local to global quorum sensing.

Physical review. E Dec 21, 2016
Bacteria communicate using external chemical signals called autoinducers (AI) in a process known as quorum sensing (QS). QS efficiency is reduced by both limitations of AI diffusion and potential interference from neighboring strains. There is thus a...
Models, Biological Bacterial Physiological Phenomena Quorum Sensing Signal Transduction
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