AIMC Topic: Signal Transduction

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A system of recurrent neural networks for modularising, parameterising and dynamic analysis of cell signalling networks.

Bio Systems
In this paper, we show how to extend our previously proposed novel continuous time Recurrent Neural Networks (RNN) approach that retains the advantage of continuous dynamics offered by Ordinary Differential Equations (ODE) while enabling parameter es...

Basic fibroblast growth factor is critical to reprogramming buffalo (Bubalus bubalis) primordial germ cells into embryonic germ stem cell-like cells.

Theriogenology
Primordial germ cells (PGCs) are destined to form gametes in vivo, and they can be reprogrammed into pluripotent embryonic germ (EG) cells in vitro. Buffalo PGC have been reported to be reprogrammed into EG-like cells, but the identities of the major...

Spatial dispersal of bacterial colonies induces a dynamical transition from local to global quorum sensing.

Physical review. E
Bacteria communicate using external chemical signals called autoinducers (AI) in a process known as quorum sensing (QS). QS efficiency is reduced by both limitations of AI diffusion and potential interference from neighboring strains. There is thus a...

Predictive diagnosis of major depression using NMR-based metabolomics and least-squares support vector machine.

Clinica chimica acta; international journal of clinical chemistry
BACKGROUND: Major depressive (MD) disorder is a serious psychiatric disorder that can result in suicidal behavior if not treated. The MD diagnosis using a standardized instrument instead of a structured interview will be advantageous for treatment an...

The method for breast cancer grade prediction and pathway analysis based on improved multiple kernel learning.

Journal of bioinformatics and computational biology
Breast cancer histologic grade represents the morphological assessment of the tumor's malignancy and aggressiveness, which is vital in clinically planning treatment and estimating prognosis for patients. Therefore, the prediction of breast cancer gra...

Analysis of Important Gene Ontology Terms and Biological Pathways Related to Pancreatic Cancer.

BioMed research international
Pancreatic cancer is a serious disease that results in more than thirty thousand deaths around the world per year. To design effective treatments, many investigators have devoted themselves to the study of biological processes and mechanisms underlyi...

Modelling with ANIMO: between fuzzy logic and differential equations.

BMC systems biology
BACKGROUND: Computational support is essential in order to reason on the dynamics of biological systems. We have developed the software tool ANIMO (Analysis of Networks with Interactive MOdeling) to provide such computational support and allow insigh...