Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Jun 10, 2021
Sarcomatoid mesothelioma is an aggressive malignancy that can be challenging to distinguish from benign spindle cell mesothelial proliferations based on biopsy, and this distinction is crucial to patient treatment and prognosis. A novel deep learning...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
May 20, 2021
The use of immunohistochemistry in the reporting of prostate biopsies is an important adjunct when the diagnosis is not definite on haematoxylin and eosin (H&E) morphology alone. The process is however inherently inefficient with delays while waiting...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Apr 26, 2021
The surgical margin status of breast lumpectomy specimens for invasive carcinoma and ductal carcinoma in situ (DCIS) guides clinical decisions, as positive margins are associated with higher rates of local recurrence. The "cavity shave" method of mar...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Mar 29, 2021
Prostate cancer is a leading cause of morbidity and mortality for adult males in the US. The diagnosis of prostate carcinoma is usually made on prostate core needle biopsies obtained through a transrectal approach. These biopsies may account for a si...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Dec 9, 2020
Non-alcoholic steatohepatitis (NASH) is a fatty liver disease characterized by accumulation of fat in hepatocytes with concurrent inflammation and is associated with morbidity, cirrhosis and liver failure. After extraction of a liver core biopsy, tis...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Nov 13, 2020
Recent advances in artificial intelligence, particularly in the field of deep learning, have enabled researchers to create compelling algorithms for medical image analysis. Histological slides of basal cell carcinomas (BCCs), the most frequent skin t...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Oct 16, 2020
Coronavirus disease 2019 (COVID-19) is a novel disease resulting from infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has quickly risen since the beginning of 2020 to become a global pandemic. As a result of the rap...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Oct 1, 2020
Tumor-infiltrating lymphocytes (TIL) have potential prognostic value in melanoma and have been considered for inclusion in the American Joint Committee on Cancer (AJCC) staging criteria. However, interobserver discordance continues to prevent the ado...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Sep 18, 2020
Hepatocellular carcinoma (HCC) is a representative primary liver cancer caused by long-term and repetitive liver injury. Surgical resection is generally selected as the radical cure treatment. Because the early recurrence of HCC after resection is as...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Sep 3, 2020
Phosphatase and tensin homolog (PTEN) loss is associated with adverse outcomes in prostate cancer and has clinical potential as a prognostic biomarker. The objective of this work was to develop an artificial intelligence (AI) system for automated det...