AIMC Topic: Age of Onset
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Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation.
NeuroImage. Clinical
Mar 31, 2019
Adolescent binge drinking has been associated with higher risks for the development of many health problems throughout the lifespan. Adolescents undergo multiple changes that involve the co-development processes of brain, personality and behavior; th...
Development of Machine Learning Algorithms for Prediction of 5-Year Spinal Chordoma Survival.
World neurosurgery
Aug 8, 2018
BACKGROUND: Chordomas are locally invasive slow-growing tumors that are difficult to study because of the rarity of the tumors and the lack of significant volumes of patients with longitudinal follow-up. As such, there are currently no machine learni...
Identification of candidate serum biomarkers of childhood-onset growth hormone deficiency using SWATH-MS and feature selection.
Journal of proteomics
Jan 6, 2018
UNLABELLED: A typical clinical manifestation of growth hormone deficiency (GHD) is a short stature resulting from delayed growth, but GHD affects bone health, cardiovascular function and metabolic profile and therefore quality of life. Although early...
Broad clinical spectrum and diverse outcomes of prolactinoma with pediatric onset: medication-resistant and recurrent cases.
Endocrine journal
Dec 27, 2017
Prolactinoma is a benign tumor of the pituitary gland that rarely occurs in children and adolescents; thus, the clinical spectrum and long-term prognosis in these patients remain unknown. This study was performed to investigate the long-term outcomes...
Age at drinking onset, age at first intoxication, and delay to first intoxication: Assessing the concurrent validity of measures of drinking initiation with alcohol use and related problems.
Addictive behaviors
Dec 21, 2017
INTRODUCTION: Drinking at an early age (AO) and quickly progressing to drinking to intoxication (Delay=Age of Intoxication[AI]-AO) confer risk for alcohol use and alcohol-related problems. However, inconsistencies exist in the literature, which may r...
Optimal adjuvant endocrine treatment of ER+/HER2+ breast cancer patients by age at diagnosis: A population-based cohort study.
European journal of cancer (Oxford, England : 1990)
Dec 21, 2017
BACKGROUND: Prior randomised controlled trials on adjuvant hormonal therapy included HER2 patients; however, a differential effect of aromatase inhibitors (AIs) versus tamoxifen (TAM) may have been missed in ER+/HER2+ patients that comprise 7-15% of ...
Low vitamin D level in pediatric patients with new onset type 1 diabetes is common, especially if in ketoacidosis.
Pediatric diabetes
Dec 23, 2015
BACKGROUND: Vitamin D deficiency (VDD) adversely affects bone health. US data on prevalence of VDD or vitamin D insufficiency (VDI) at diagnosis of type 1 diabetes (T1D) is lacking. Low serum 25-hydroxyvitamin D (25OHD) is speculated to increase the ...
Machine learning approaches for integrating clinical and imaging features in late-life depression classification and response prediction.
International journal of geriatric psychiatry
Feb 17, 2015
OBJECTIVE: Currently, depression diagnosis relies primarily on behavioral symptoms and signs, and treatment is guided by trial and error instead of evaluating associated underlying brain characteristics. Unlike past studies, we attempted to estimate ...
An artificial intelligence model for Lhermitte's sign in patients with pediatric-onset multiple sclerosis: A follow-up study.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Feb 1, 2025
BACKGROUND: Lhermitte's sign (LS) is an important clinical marker for patients with multiple sclerosis (MS). Research on pediatric-onset MS (POMS) and LS is limited. To date, there has been no research conducted on the clinical and artificial intelli...
Paediatric/young versus adult patients with long QT syndrome.
Open heart
Sep 1, 2021
INTRODUCTION: Long QT syndrome (LQTS) is a less prevalent cardiac ion channelopathy than Brugada syndrome in Asia. The present study compared the outcomes between paediatric/young and adult LQTS patients.
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