AIMC Topic: Aged

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Automated quantitative analysis of peri-articular bone microarchitecture in HR-pQCT knee images.

Computer methods and programs in biomedicine
UNLABELLED: Applying HR-pQCT to image the knee necessitates the development and validation of novel image analysis workflows. Here, we present and validate the first automated workflow for in vivo quantitative assessment of peri-articular bone densit...

Searching for peripheral proteomic markers of primary aldosteronism.

Endocrine
PURPOSE: Primary aldosteronism (PA) is prevalent among hypertensive patients, and associated with worsened cardiovascular outcomes compared to essential hypertension (HT). Screening and diagnostics for PA are currently complicated and invasive, why n...

Assessment of outcomes and machine Learning-based models to predict local failure risk following stereotactic radiosurgery for small brain metastases.

Journal of neuro-oncology
INTRODUCTION: We assessed the outcomes of stereotactic radiosurgery (SRS) for small intact brain metastases (SBM) (≤ 2 cm) and developed machine learning (ML) algorithms to predict the probability of local failure (LF).

Uncovering Image-Driven Subtypes with Distinct Pathology and Clinical Course in Autopsy-Confirmed Four Repeat Tauopathies.

Annals of neurology
OBJECTIVES: The four-repeat (4R) tauopathies are a group of neurodegenerative diseases, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and globular glial tauopathy (GGT). This study aimed to characterize spatiotempor...

Reimagining Resilience in Aging: Leveraging AI/ML, Big Data Analytics, and Systems Innovation.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
As the aging population in the United States grows, the need for an integrated approach to support older adults has become increasingly urgent. The SUNSHINE framework, Seniors Uniting Nationwide to Support Health, INtegrated Care, and Evolution, offe...

The knowledge distillation-assisted multimodal model for osteoporosis screening.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Osteoporosis is characterized by reduced bone mass and deterioration of bone structure, yet screening rates prior to fractures remain low. Given its high prevalence and severe consequences, developing an effective osteoporos...

Combining structural equation modeling analysis with machine learning for early malignancy detection in Bethesda Category III thyroid nodules.

Artificial intelligence in medicine
Atypia of Undetermined Significance (AUS), classified as Category III in the Bethesda Thyroid Cytopathology Reporting System, presents significant diagnostic challenges for clinicians. This study aims to develop a clinical decision support system tha...

Interpretable machine learning models based on body composition and inflammatory nutritional index (BCINI) to predict early postoperative recurrence of colorectal cancer: Multi-center study.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Colorectal cancer (CRC) ranks among the most prevalent cancers worldwide, with early postoperative recurrence remaining a major cause of mortality. Body composition and inflammatory-nutritional indices (BCINI) have demonstra...

Radiomics classification of fresh and old vertebral compression fractures: Impact of compression grade and morphology on diagnostic performance.

European journal of radiology
OBJECTIVES: To develop a radiomics model for identifying fresh or old vertebral compression fractures (VCFs) from CT images, thereby assisting physicians in making more effective decisions.