AIMC Topic: Antineoplastic Agents, Phytogenic

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Revealing the anti-tumor mechanisms of aromatic oil from Amomum villosum through integrated network pharmacology, bioinformatics, machine learning, single-cell sequencing, and cell experiments.

Biochemical and biophysical research communications
The dry fruits of Amomum villosum (Av) are a traditional Chinese medicine used for gastrointestinal disease. Aromatic oil has been reported to have anti-tumor properties. However, its therapeutic potential and molecular mechanisms remain unclear. Int...

Systems pharmacology approaches decipher the anti-cancer efficacy of ethnopharmacological agents in hepatocellular carcinoma.

Scientific reports
Hepatocellular carcinoma (HCC) poses a significant global health burden with limited therapeutic efficacy. Chinese herbal medicines (CHMs) offer multi-target potential, yet their systematic screening and mechanistic elucidation remain challenging. We...

Machine learning-based fabrication of phytogenic NiO nanoparticles for anticancer activity in HepG2 Cell Culture.

Journal of materials science. Materials in medicine
Metal oxide nanomaterials play a central role in biomedical applications due to their unique physicochemical properties. In particular, various treatment methods such as drug delivery, hyperthermia therapy, radiation, and chemotherapy are used for th...

Evaluation of antioxidant, anticholinesterase and antiproliferative potential of Artemisia herba-alba by artificial intelligence-assisted extraction optimization.

Scientific reports
In this study, in order to maximize the biological activity of Artemisia herba-alba Asso, extraction conditions were optimized by two different methods: Response Surface Methodology (RSM) and Artificial Neural Network-Genetic Algorithm (ANN-GA). A to...

Targeting cancer epigenetics with PPD-type ginsenosides: A systematic review of mechanisms and therapeutic potential.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: For centuries, Panax ginseng C.A. Meyer has been widely employed in traditional medicine, and its primary therapeutic constituents are a class of compounds known as ginsenosides. In particular, protopanaxadiol (PPD)-type ginsenosides exhi...

Glabridin from L. Exhibits Anti-Triple-Negative Breast Cancer Effects by Regulating Various Cell Cycle Genes.

Journal of agricultural and food chemistry
Glabridin (GLA), a characteristic polyphenolic extracted from the renowned sweet plant L., demonstrates potent anticancer effects. This study aims to investigate the effects of GLA on triple-negative breast cancer (TNBC) and its underlying mechanisms...

An integrative analysis reveals mechanisms of Prunella vulgaris in thyroid cancer metastasis.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) is a major contributor to poor prognosis. Prunella vulgaris (P. vulgaris), a traditional medicinal herb, has shown potential in inhibiting PTC metastasis, but its molecular ...

Machine learning modeling and response surface methodology driven antioxidant and anticancer activities of chitosan nanoparticle-mediated extracts of Bacopa monnieri.

International journal of biological macromolecules
This study investigates the potential of chitosan nanoparticles (CNPs) in enhancing the bioavailability and efficacy of Bacopa monnieri extracts, known for their neuroprotective, antioxidant, and anticancer properties. Different concentrations of CNP...

Bioactive components of Jiedu Sangen decoction against colorectal cancer: A novel and comprehensive research strategy for natural drug development.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Jiedu Sangen Decoction (JSD) is widely used in the treatment of colorectal cancer (CRC) patients in southern China due to its good clinical efficacy, but the effective active ingredients are still unknown.