AIMC Topic: Antineoplastic Agents, Phytogenic

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Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway.

International journal of clinical and experimental pathology Nov 1, 2015
Increasing evidences have indicated the role of garlicin in inhibiting the progression of various tumors including glioma, pulmonary carcinoma and pancreatic carcinoma, via mediating cell apoptosis or cell cycle. The regulatory effect and related mol...
Disulfides Allyl Compounds Protein Kinase Inhibitors Cholangiocarcinoma Phosphatidylinositol 3-Kinase Phosphoinositide-3 Kinase Inhibitors Dose-Response Relationship, Drug Antineoplastic Agents, Phytogenic Phosphorylation Proto-Oncogene Proteins c-akt Bile Duct Neoplasms Cell Proliferation Signal Transduction Cell Movement Neoplasm Invasiveness Humans Cell Line, Tumor
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Unraveling the molecular mechanisms of paclitaxel in high-grade serous ovarian cancer through network pharmacology.

Scientific reports May 12, 2025
High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of epithelial ovarian cancer, often diagnosed at advanced stages with a poor prognosis. Paclitaxel (PTX), a standard chemotherapeutic agent for HGSOC, exerts cytotoxic...
Gene Regulatory Networks Computational Biology Gene Expression Regulation, Neoplastic Antineoplastic Agents, Phytogenic Ovarian Neoplasms Tumor Microenvironment Biomarkers, Tumor Molecular Docking Simulation Protein Interaction Maps Paclitaxel Kaplan-Meier Estimate Cystadenocarcinoma, Serous Network Pharmacology Humans Prognosis Female
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In-silico prediction of anti-breast cancer activity of ginger (Zingiber officinale) using machine learning techniques.

Breast disease Jan 1, 2024
INTRODUCTION: Indonesian civilization extensively uses traditional medicine to cure illnesses and preserve health. The lack of knowledge on the security and efficacy of medicinal plants is still a significant concern. Although the precise chemicals r...
Humans Molecular Docking Simulation Plant Extracts Antineoplastic Agents, Phytogenic Catechols Zingiber officinale Machine Learning Computer Simulation Female Breast Neoplasms
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Cytotoxicity and molecular docking analysis of racemolactone I, a new sesquiterpene lactone isolated from .

Pharmaceutical biology Dec 1, 2021
CONTEXT: Traditionally, Hook. f. (Asteraceae) has been reported to be effective in cancer treatment which motivated the authors to explore the plant for novel anticancer compounds.
HeLa Cells Inula Lactones Sesquiterpenes Cell Survival Humans Antineoplastic Agents, Phytogenic Molecular Docking Simulation A549 Cells Cell Line, Tumor Plant Roots Apoptosis Membrane Potential, Mitochondrial
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Volatile constituents and in vitro activity of Syzygium aromaticum flower buds (clove) against human cancer cell lines.

Pakistan journal of pharmaceutical sciences Nov 1, 2020
The methanolic extract (SA-EXT) of Syzygium aromaticum flower buds and its fractions tested against three human cancer cell lines viz uterine cervix (HeLa), breast (MCF-7) and lung NCI (H-460) using sulforhodamine-B assay. The ethyl acetate soluble s...
Eugenol Humans Flowers Methanol Cell Line, Tumor Syzygium Acetates Antineoplastic Agents, Phytogenic Volatile Organic Compounds Gas Chromatography-Mass Spectrometry Drug Screening Assays, Antitumor HeLa Cells MCF-7 Cells
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Investigation of the biochemical and apoptotic changes in breast cancer cells treated with leaf extract from tea (Camellia sinensis L.) grown with added boric acid.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
Tea obtained from the leaves of Camellia sinensis L., a medicinal plant, is a widely popular beverage. Deficiency in boron, a micronutrient for C. sinensis, affects the growth as well as the quality of tea. The aim of this study was to explore whethe...
Camellia sinensis MCF-7 Cells Boric Acids Humans Plant Extracts Female Cell Proliferation Breast Neoplasms Apoptosis Oxidative Stress Antineoplastic Agents, Phytogenic Antioxidants Plant Leaves
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Assessing the Anti-cancer Therapeutic Mechanism of a Herbal Combination for Breast Cancer on System-level by a Network Pharmacological Approach.

Anticancer research Sep 1, 2020
BACKGROUND/AIM: Accumulating evidence has shown therapeutic effects of herbals on breast cancer, a commonly diagnosed malignancy in women worldwide. However, their underlying mechanisms remain unclear. We aimed to explore the mode of action of a rece...
Humans Drugs, Chinese Herbal Neural Networks, Computer Workflow Female Technology, Pharmaceutical Systems Biology Breast Neoplasms Astragalus propinquus Medicine, Chinese Traditional Cell Line, Tumor Antineoplastic Agents, Phytogenic Computational Biology Drug Screening Assays, Antitumor
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Antioxidant and antiproliferative activities of protein hydrolysate from the rhizomes of Zingiberaceae plants.

Pakistan journal of pharmaceutical sciences Nov 1, 2016
Plant proteins have been investigated for their antioxidant activities, but there are still no reports detailing the antioxidant activity levels of plants in the Zingiberaceae family, which are popular food agents and used in folklore medicine. In th...
Humans Neoplasms Antioxidants Plant Extracts Cell Proliferation Molecular Weight Zingiberaceae Phytotherapy Inhibitory Concentration 50 Hep G2 Cells Plants, Medicinal Chromatography, Ion Exchange Plant Proteins Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Protein Hydrolysates Rhizome Dose-Response Relationship, Drug Biphenyl Compounds Antineoplastic Agents, Phytogenic Picrates Ascorbic Acid
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Diterpenoid Tanshinones, the extract from Danshen (Radix Salviae Miltiorrhizae) induced apoptosis in nine human cancer cell lines.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Aug 1, 2016
OBJECTIVE: To identify the active anti-tumor constituents in the extract from Danshen (Radix Salviae Miltiorrhizae) and investigate the mechanisms underlying the actions.
Drugs, Chinese Herbal Abietanes Poly(ADP-ribose) Polymerases Salvia miltiorrhiza Cell Line, Tumor Humans Cell Proliferation Apoptosis Caspase 3 Antineoplastic Agents, Phytogenic
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A systematic approach to prioritize drug targets using machine learning, a molecular descriptor-based classification model, and high-throughput screening of plant derived molecules: a case study in oral cancer.

Molecular bioSystems Dec 1, 2015
Systems-biology inspired identification of drug targets and machine learning-based screening of small molecules which modulate their activity have the potential to revolutionize modern drug discovery by complementing conventional methods. To utilize ...
Humans Machine Learning Drug Discovery Cell Line, Tumor ROC Curve Molecular Conformation Binding Sites Antineoplastic Agents, Phytogenic Protein Interaction Mapping Gene Regulatory Networks Receptors, CXCR4 Protein Binding Models, Molecular Computational Biology Mouth Neoplasms Gene Expression Regulation, Neoplastic High-Throughput Screening Assays
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