AIMC Topic: Antineoplastic Combined Chemotherapy Protocols
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Artificial Intelligence-Powered Human Epidermal Growth Factor Receptor 2 and Tumor Microenvironment Analysis in Human Epidermal Growth Factor Receptor 2-Amplified Metastatic Colorectal Cancer: Exploratory Analysis of Phase II TRIUMPH Trial.
JCO precision oncology
Jan 17, 2025
PURPOSE: Human epidermal growth factor receptor 2 (HER2)-targeted therapies have shown promise in treating -amplified metastatic colorectal cancer (mCRC). Identifying optimal biomarkers for treatment decisions remains challenging. This study explores...
First-line combination therapy of immunotherapy plus anti-angiogenic drug for thoracic SMARCA4-deficient undifferentiated tumors in AIDS: a case report and review of the literature.
Frontiers in immunology
Jan 9, 2025
BACKGROUND: Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UT) exhibit a notably aggressive phenotype, which is associated with poor patient survival outcomes. These tumors are generally resistant to conventional cytotoxic chemotherapy, ...
Hepatoid adenocarcinoma of the stomach with ideal response to neoadjuvant chemo-immunotherapy: a case report.
Frontiers in immunology
Jan 8, 2025
Hepatoid adenocarcinoma of the stomach (HAS) is a rare subtype of gastric cancer characterized by histological features resembling hepatocellular carcinoma. Surgical intervention remains the preferred treatment modality for eligible patients. However...
Identification of key gene signatures for predicting chemo-immunotherapy efficacy in extensive-stage small-cell lung cancer using machine learning.
Lung cancer (Amsterdam, Netherlands)
Jan 2, 2025
OBJECTIVES: The lack of definitive biomarkers presents a significant challenge for chemo-immunotherapy in extensive-stage small-cell lung cancer (ES-SCLC). We aimed to identify key genes associated with chemo-immunotherapy efficacy in ES-SCLC through...
Female
Aged
Biomarkers, Tumor
Male
Middle Aged
Gene Expression Regulation, Neoplastic
Humans
Gene Expression Profiling
Antineoplastic Combined Chemotherapy Protocols
Transcriptome
Treatment Outcome
Machine Learning
Lung Neoplasms
Neoplasm Staging
Prospective Studies
Immunotherapy
Small Cell Lung Carcinoma
Prognosis
Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma.
CPT: pharmacometrics & systems pharmacology
Dec 25, 2024
We employed a mechanistic learning approach, integrating on-treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post-progression survival (PPS)-the duration from the time of document...
Improving the prediction of patient survival with the aid of residual convolutional neural network (ResNet) in colorectal cancer with unresectable liver metastases treated with bevacizumab-based chemotherapy.
Cancer imaging : the official publication of the International Cancer Imaging Society
Dec 18, 2024
BACKGROUND: To verify overall survival predictions made with residual convolutional neural network-determined morphological response (ResNet-MR) in patients with unresectable synchronous liver-only metastatic colorectal cancer (mCRC) treated with bev...
Predicting chemotherapy responsiveness in gastric cancer through machine learning analysis of genome, immune, and neutrophil signatures.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Dec 2, 2024
BACKGROUND: Gastric cancer is a major oncological challenge, ranking highly among causes of cancer-related mortality worldwide. This study was initiated to address the variability in patient responses to combination chemotherapy, highlighting the nee...
Using Machine Learning Models to Predict Pathologic Complete Response to Neoadjuvant Chemotherapy in Breast Cancer.
JCO clinical cancer informatics
Nov 22, 2024
PURPOSE: Neoadjuvant chemotherapy (NAC) is increasingly used in breast cancer. Predictive modeling is useful in predicting pathologic complete response (pCR) to NAC. We test machine learning (ML) models to predict pCR in breast cancer and explore met...
Association of artificial intelligence-based immunoscore with the efficacy of chemoimmunotherapy in patients with advanced non-squamous non-small cell lung cancer: a multicentre retrospective study.
Frontiers in immunology
Nov 6, 2024
PURPOSE: Currently, chemoimmunotherapy is effective only in a subset of patients with advanced non-squamous non-small cell lung cancer. Robust biomarkers for predicting the efficacy of chemoimmunotherapy would be useful to identify patients who would...
Computed Tomography-Based Radiomics with Machine Learning Outperforms Radiologist Assessment in Estimating Colorectal Liver Metastases Pathologic Response After Chemotherapy.
Annals of surgical oncology
Oct 5, 2024
OBJECTIVES: This study was designed to assess computed tomography (CT)-based radiomics of colorectal liver metastases (CRLM), extracted from posttreatment scans in estimating pathologic treatment response to neoadjuvant therapy, and to compare treatm...
Machine Learning
Prognosis
Retrospective Studies
Tomography, X-Ray Computed
Humans
Radiomics
Male
Middle Aged
Liver Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Female
Aged
Adult
Colorectal Neoplasms
Neoadjuvant Therapy
Follow-Up Studies
Radiologists
Response Evaluation Criteria in Solid Tumors
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