AIMC Topic: Apoptosis

Clear Filters Showing 81 to 90 of 222 articles

Exploring a specialized programmed-cell death patterns to predict the prognosis and sensitivity of immunotherapy in cutaneous melanoma via machine learning.

Apoptosis : an international journal on programmed cell death Apr 14, 2024
The mortality and therapeutic failure in cutaneous melanoma (CM) are mainly caused by wide metastasis and chemotherapy resistance. Meanwhile, immunotherapy is considered a crucial therapy strategy for CM patients. However, the efficiency of currently...
Machine Learning Prognosis Melanoma Humans Immunotherapy Gene Expression Regulation, Neoplastic Apoptosis Melanoma, Cutaneous Malignant Skin Neoplasms Tumor Microenvironment Biomarkers, Tumor
View on PubMed DOI

Identification of potential cell death-related biomarkers for diagnosis and treatment of osteoporosis.

BMC musculoskeletal disorders Mar 25, 2024
BACKGROUND: This study aimed to identify potential biomarkers for the diagnosis and treatment of osteoporosis (OP).
Biomarkers Apoptosis Cell Death Humans Machine Learning Databases, Factual
View on PubMed DOI

Robotic Actuation-Mediated Quantitative Mechanogenetics for Noninvasive and On-Demand Cancer Therapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Mar 21, 2024
Cell mechanotransduction signals are important targets for physical therapy. However, current physiotherapy heavily relies on ultrasound, which is generated by high-power equipment or amplified by auxiliary drugs, potentially causing undesired side e...
Robotics Mechanotransduction, Cellular Humans Animals Neoplasms Disease Models, Animal Apoptosis Cell Line, Tumor Mice
View on PubMed DOI

A Machine Learning Computational Framework Develops a Multiple Programmed Cell Death Index for Improving Clinical Outcomes in Bladder Cancer.

Biochemical genetics Feb 14, 2024
Comprehensive action patterns of programmed cell death (PCD) in bladder cancer (BLCA) have not yet been thoroughly investigated. Here, we collected 19 different PCD patterns, including 1911 PCD-related genes, and developed a multiple programmed cell ...
Humans Machine Learning Computational Biology Nomograms Urinary Bladder Neoplasms Apoptosis Prognosis Female Male
View on PubMed DOI

Paeonol impacts ovarian cancer cell proliferation, migration, invasion and apoptosis via modulating the transforming growth factor beta/smad3 signaling pathway.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Feb 7, 2024
Paeonol (2-hydroxy-4-methoxyphenylacetophenone) is a natural phenolic component isolated from the root bark of peony with multiple pharmacological activities and has been proven to have anti-cancer effects. The objective of this study is to investiga...
Apoptosis Cell Proliferation Humans bcl-2-Associated X Protein Signal Transduction Female Ovarian Neoplasms Acetophenones Cell Movement Cell Line, Tumor Transforming Growth Factor beta
View on PubMed DOI

T6496 targeting EGFR mediated by T790M or C797S mutant: machine learning, virtual screening and bioactivity evaluation study.

Journal of biomolecular structure & dynamics Jan 4, 2024
Acquired resistance to EGFR is a major impediment in lung cancer treatment, highlighting the urgent need to discover novel compounds to overcome EGFR drug resistance. In this study, we utilized in silico methods and bioactivity evaluation for drug di...
Protein Kinase Inhibitors Mutation Drug Resistance, Neoplasm ErbB Receptors Drug Discovery Antineoplastic Agents Cell Line, Tumor Apoptosis Drug Screening Assays, Antitumor Protein Binding Cell Proliferation Humans Machine Learning Molecular Docking Simulation
View on PubMed DOI

Mechanism of TNF- α inducing apoptosis and autophagy of chondrocytes by activating NF- κ B signal pathway.

Cellular and molecular biology (Noisy-le-Grand, France) Dec 31, 2023
This study aimed to explore the mechanism of apoptosis and autophagy of chondrocytes induced by tumor necrosis factor α (TNA-α) by activating the NF-κB signal pathway. For this purpose, 24 SD rats were selected for feeding. The knee cartilage was cut...
Rats Signal Transduction Interleukin-6 Tumor Necrosis Factor-alpha NF-KappaB Inhibitor alpha Rats, Sprague-Dawley Interleukin-12 Apoptosis Animals Cells, Cultured Chondrocytes Interleukin-1 Autophagy RNA, Messenger NF-kappa B
View on PubMed DOI

Influences of microRNA-451 on the expression of HMGB1 in myocardial cells and its mechanism in ischemia-reperfusion injury.

Cellular and molecular biology (Noisy-le-Grand, France) Dec 31, 2023
This work aimed to understand the underlying mechanism of micro-ribonucleic acid (MicroRNA) (miR)-451 in ischemia-reperfusion injury (IRI) and the influences of miR-451 on high mobility group box 1 protein (HMGB1) in myocardial cells, 30 specific pat...
MicroRNAs HMGB1 Protein Myocardial Reperfusion Injury Superoxide Dismutase Rats, Sprague-Dawley Apoptosis Animals Male Rats
View on PubMed DOI

Analysis of the improvement effect of Astragalus extract on oxidative stress injury in viral myocarditis through STAT3/IL-6.

Cellular and molecular biology (Noisy-le-Grand, France) Dec 31, 2023
The objective of this study was to investigate the improvement effect of Astragalus (AS) extract on oxidative stress (OS) and inflammatory response of myocarditis (MYO) cells through the STAT3/IL-6 axis. For this purpose, The MYO model cells prepared...
STAT3 Transcription Factor Inflammation Interleukin-6 Apoptosis Humans Oxidative Stress Myocarditis Cytokines
View on PubMed DOI

Postbiotic Activities of : Impacts on Viability, Structural Integrity, and Cell Death Markers in Human Intestinal C2BBe1 Cells.

Pathogens (Basel, Switzerland) Dec 23, 2023
Acute diarrheal disease (ADD) caused by rotavirus (RV) contributes significantly to morbidity and mortality in children under five years of age. Currently, there are no specific drugs for the treatment of RV infections. Previously, we reported the an...
Bifidobacterium adolescentis Cell Death Tight Junctions Apoptosis Cell Line Cell Survival Humans Rotavirus Probiotics Intestines Rotavirus Infections Bacterial Proteins
View on PubMed DOI
Popular Topics
Recent Journals