AIMC Topic: Benzimidazoles

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Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET.

Molecular oncology Dec 22, 2015
BACKGROUND: Rationalization of antiangiogenics requires biomarkers. Vascular re-normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular...
Positron-Emission Tomography Quinolones Neovascularization, Pathologic Mice, Nude Pancreatic Neoplasms Breast Benzimidazoles Antimetabolites, Antineoplastic Deoxycytidine Pancreas Cell Hypoxia Fluorine Radioisotopes Female Breast Neoplasms Animals Cell Line, Tumor Mice Angiogenesis Inhibitors Humans Gemcitabine Misonidazole
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Field study analysis of the influences of deworming regimens and housing conditions on parasites and sperm output in 21 European boar studs.

Veterinary journal (London, England : 1997) Dec 2, 2015
The current study reports the parasitological results of a quality control audit in 21 European boar studs. Field investigations were performed over a 2-year period (2012-2013) during the winter and spring. From each stud, an average of 30 (range, 25...
Nematode Infections Nematoda Sus scrofa Communicable Disease Control Animals Male Germany Models, Theoretical Swine Seasons Housing, Animal Switzerland Lactones Benzimidazoles Swine Diseases Spermatozoa Austria Feces
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Drug-Drug interactions and special considerations in breast cancer patients treated with CDK4/6 inhibitors: A comprehensive review.

Cancer treatment reviews Jun 1, 2025
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have reshaped the treatment paradigm of hormone receptor positive (HR + )/HER2-negative breast cancer in both adjuvant and metastatic settings. However, their metabolism via the cytochrome P450 (CYP3A4...
Pyridines Piperazines Drug Interactions Female Humans Breast Neoplasms Antineoplastic Agents Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Protein Kinase Inhibitors Aminopyridines Benzimidazoles Purines
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DEVELOPMENT AND VALIDATION OF HPLC ANALYTICAL METHODS USED-FOR DETERMINATION OF ASSAY, CONTENT UNIFORMITY AND DISSOLUTION OF IMMEDIATE RELEASE CANDESARTAN CILEXETIL 32 MG TABLETS.

Acta poloniae pharmaceutica Mar 1, 2017
New analytical methods have been developed and validated on high performance liquid chromatography (HPLC) to assess the assay, content uniformity and dissolution of immediate release candesartan cilexetil 32 mg tablets. Method development studies wer...
Tetrazoles Benzimidazoles Angiotensin II Type 1 Receptor Blockers Chromatography, High Pressure Liquid Limit of Detection Temperature Solubility Biphenyl Compounds Hydrogen-Ion Concentration Linear Models Reproducibility of Results Drug Liberation Solvents Tablets Buffers Drug Compounding Chemistry, Pharmaceutical
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Effects of Candesartan Cilexetil Compared with Amlodipine on Serum Asymmetric Dimethylarginine Levels in the Chronic Stage of Cerebral Infarction: A Preliminary Study.

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi Jan 1, 2016
OBJECTIVE: Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor and a marker of vascular endothelial damage. Angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker (ARB) are reported to reduce the s...
Arginine Tetrazoles Benzimidazoles Aged Amlodipine Aged, 80 and over Male Antihypertensive Agents Humans Cerebral Infarction Biomarkers Biphenyl Compounds Hypertension Female Chronic Disease
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Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.

Neoplasia (New York, N.Y.) Sep 1, 2015
Cellular senescence is a barrier to tumorigenesis in normal cells, and tumor cells undergo senescence responses to genotoxic stimuli, which is a potential target phenotype for cancer therapy. However, in this setting, mixed-mode responses are common ...
Dose-Response Relationship, Drug Neural Networks, Computer Cellular Senescence User-Computer Interface HCT116 Cells Humans Benzimidazoles Gene Regulatory Networks G1 Phase
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