AIMC Topic: Biomarkers, Tumor

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Are we at a crossroads or a plateau? Radiomics and machine learning in abdominal oncology imaging.

Abdominal radiology (New York)
Advances in radiomics and machine learning have driven a technology boom in the automated analysis of radiology images. For the past several years, expectations have been nearly boundless for these new technologies to revolutionize radiology image an...

A novel machine learning-derived decision tree including uPA/PAI-1 for breast cancer care.

Clinical chemistry and laboratory medicine
Background uPA and PAI-1 are breast cancer biomarkers that evaluate the benefit of chemotherapy (CT) for HER2-negative, estrogen receptor-positive, low or intermediate grade patients. Our objectives were to observe clinical routine use of uPA/PAI-1 a...

A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic.

JCO clinical cancer informatics
PURPOSE: Dynamic network models predict clinical prognosis and inform therapeutic intervention by elucidating disease-driven aberrations at the systems level. However, the personalization of model predictions requires the profiling of multiple model ...

Machine learning approaches to decipher hormone and HER2 receptor status phenotypes in breast cancer.

Briefings in bioinformatics
Breast cancer prognosis and administration of therapies are aided by knowledge of hormonal and HER2 receptor status. Breast cancer lacking estrogen receptors, progesterone receptors and HER2 receptors are difficult to treat. Regarding large data repo...

Nomogram and Artificial Neural Network for Prognostic Performance on the Albumin-Bilirubin Grade for Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization.

Journal of vascular and interventional radiology : JVIR
PURPOSE: To construct the albumin-bilirubin (ALBI) grade and the Child-Turcotte-Pugh (CTP) score based on nomograms, as well as to develop an artificial neural network (ANN) to compare the prognostic performance of the 2 scores for hepatocellular car...

Ultrashort ssDNA in Retinoblastoma Patients Blood Plasma Detected by a Novel High Resolution HPLC Technique: a Preliminary Report.

Acta medica (Hradec Kralove)
A significant population of ultrashort (50-150n) single-stranded DNA fragments were found in exosome-free blood plasma of retinoblastoma patients (6.84 ng mL-1), but not in plasma of healthy donors. An original high resolution HPLC technique has been...

GIDB: a knowledge database for the automated curation and multidimensional analysis of molecular signatures in gastrointestinal cancer.

Database : the journal of biological databases and curation
Gastrointestinal (GI) cancer is common, characterized by high mortality, and includes oesophagus, gastric, liver, bile duct, pancreas, rectal and colon cancers. The insufficient specificity and sensitivity of biomarkers is still a key clinical hindra...

Radiomics with artificial intelligence for precision medicine in radiation therapy.

Journal of radiation research
Recently, the concept of radiomics has emerged from radiation oncology. It is a novel approach for solving the issues of precision medicine and how it can be performed, based on multimodality medical images that are non-invasive, fast and low in cost...