Pancreatic cancer remains one of the deadliest malignancies due to its silent progression and lack of early diagnostic tools. Here, we report a light-addressable photoelectrochemical (LAMT-PEC) biosensing system featuring single-atom Au-TiO photoelec...
Immunotherapy has become a cornerstone in the treatment of advanced gastric cancer (GC). However, identifying reliable predictive biomarkers remains a considerable challenge. This study demonstrates the potential of integrating multimodal baseline da...
BACKGROUND: Prognostic tools for determining patients with indolent breast cancers (BCs) are far from optimal, leading to extensive overtreatment. Several studies have demonstrated mRNAs, lncRNAs and miRNAs to have prognostic potential in BC. Because...
Bladder cancer (BLCA) is a prevalent urological malignancy that exhibits a high degree of tumor heterogeneity and morbidity. Tumor angiogenesis, a vital hallmark of cancer, greatly influences the tumor microenvironment (TME). The emergence of anti-an...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jul 14, 2025
Over recent years, surface-enhanced Raman spectroscopy (SERS) has shown its unparalleled sensitivity and molecular specificity in biomedical applications. However, noninvasive and sensitive detection of biomarkers with conventional SERS for oral canc...
Clinica chimica acta; international journal of clinical chemistry
Jul 14, 2025
Gastrointestinal cancers (GICs) are a leading cause of cancer-related mortality worldwide, largely due to late-stage diagnosis. Liquid biopsy has emerged as a promising non-invasive diagnostic tool, utilizing circulating tumor DNA (ctDNA), circulatin...
The immune response to tumour development is frequently targeted with therapeutics but remains largely unexplored in diagnostics, despite being stronger for early-stage tumours. We present an immunodiagnostic platform to detect this. We identify a pa...
Glycosylation changes are closely related to various diseases, including cancer. The quantitative analysis of site-specific glycans at proteomics scale remains challenging due to low glycopeptide spectra interpretation. Here, we present GlyPep-Quant,...
Transcription factors (TFs) are pivotal in tumor initiation and progression, regulating downstream gene expression and modulating cellular processes. In this study, we conducted a comprehensive analysis of TF gene sets to define the molecular subtype...
Clinica chimica acta; international journal of clinical chemistry
Jul 12, 2025
Alpha-2-glycoprotein 1, zinc-binding (AZGP1), functions as a serum AZGP1 biomarker with applications in cancer detection, prognosis, and therapeutic monitoring. This review evaluates AZGP1's analytical performance and clinical utility in multiple mal...
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