BACKGROUND: Renal fibrosis is a critical factor in chronic kidney disease progression, with limited diagnostic and therapeutic options. Emerging evidence suggests RNA-binding proteins (RBPs) are pivotal in regulating cellular mechanisms underlying fi...
OBJECTIVE: We aimed at identifying acute phase biomarkers in Severe Fever with Thrombocytopenia Syndrome (SFTS), and to establish a model to predict mortality outcomes.
BACKGROUND: Juvenile idiopathic arthritis (JIA), superseding juvenile rheumatoid arthritis (JRA), is a chronic autoimmune disease affecting children and characterized by various types of childhood arthritis. JIA manifests clinically with joint inflam...
BACKGROUND: This study analyzed plasma cytokine patterns in individuals with schizophrenia (SCZ), major depressive disorder (MDD), and healthy controls, explored the link between cytokine levels and cognitive function, and created machine learning mo...
Journal of pharmaceutical and biomedical analysis
Nov 15, 2025
On account of the low concentration and complex background, most methods for detecting VOCs in exhaled breath samples required preconcentration prior to instrumental analysis. In the current study, a simple and rapid method is developed for analyzing...
Atherosclerosis (AS) is a systemic disease closely related to inflammatory cell infiltration and immune cell activation, often leading to myocardial infarction and stroke and is the leading cause of death worldwide. AS is asymptomatic in its early st...
The journal of applied laboratory medicine
Nov 4, 2025
BACKGROUND: The complete blood count (CBC) is widely used across nearly all areas of medicine. While standard CBC markers reflect basic summaries of the blood cells, modern hematology analyzers generate many additional markers from the underlying dat...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Oct 31, 2025
Dilated cardiomyopathy (DCM) is a progressive myocardial disorder lacking reliable molecular biomarkers for early diagnosis. Given the emerging role of protein lactylation in cardiovascular disease, we investigated lactylation-related genes (LRGs) in...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Oct 31, 2025
Glycosylation is a highly dynamic and complex post-translational modification that plays a pivotal role in regulating protein folding, trafficking, stability, and function. Accumulating evidence indicates that aberrant glycosylation is intimately inv...
Age-related hearing loss (HL) and sarcopenia (ARS) are prevalent geriatric syndromes sharing common risk factors. This study aimed to identify shared biomarkers and elucidate convergent pathogenic mechanisms. Transcriptomic datasets were obtained fro...
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