AIMC Topic: Brain

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Functional connectome-based predictive modeling of suicidal ideation.

Journal of affective disorders May 27, 2025
Suicide represents an egregious threat to society despite major advancements in medicine, in part due to limited knowledge of the biological mechanisms of suicidal behavior. We apply a connectome predictive modeling machine learning approach to ident...
Aged Young Adult Adult Male Machine Learning Brain Female Magnetic Resonance Imaging Connectome Neural Pathways Nerve Net Middle Aged Depressive Disorder, Major Adolescent Suicidal Ideation Humans
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Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy.

EBioMedicine May 27, 2025
BACKGROUND: The impact of high body mass index (BMI) states and associated proteomic factors on brain ageing and Alzheimer's disease (AD) remains unclear.
Male Alzheimer Disease Neuroimaging Aging Atrophy Middle Aged Female Proteomics Proteome Aged Humans Body Mass Index Aged, 80 and over Biomarkers Magnetic Resonance Imaging Brain Radiomics Obesity
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Automatic identification of Parkinsonism using clinical multi-contrast brain MRI: a large self-supervised vision foundation model strategy.

EBioMedicine May 27, 2025
BACKGROUND: Valid non-invasive biomarkers for Parkinson's disease (PD) and Parkinson-plus syndrome (PPS) are urgently needed. Based on our recent self-supervised vision foundation model the Shift Window UNET TRansformer (Swin UNETR), which uses clini...
Humans Neural Networks, Computer Brain Female Image Processing, Computer-Assisted Magnetic Resonance Imaging Parkinson Disease Aged Parkinsonian Disorders Male Middle Aged ROC Curve
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Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability.

Journal of nanobiotechnology May 26, 2025
The blood-brain barrier (BBB) represents a formidable challenge in the treatment of neurological disorders, as it restricts the passage of most therapeutic agents into the central nervous system (CNS). Research in brain-targeted delivery strategies a...
Brain Blood-Brain Barrier Drug Delivery Systems Animals Biological Products Humans Permeability
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Predicting treatment response in individuals with major depressive disorder using structural MRI-based similarity features.

BMC psychiatry May 26, 2025
BACKGROUND: Major Depressive Disorder (MDD) is a prevalent mental health condition with significant societal impact. Structural magnetic resonance imaging (sMRI) and machine learning have shown promise in psychiatry, offering insights into brain abno...
Adolescent Treatment Outcome Magnetic Resonance Imaging Remission Induction Gray Matter White Matter Adult Male Middle Aged Depressive Disorder, Major Brain Female Young Adult Humans Machine Learning
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Sex-related differences and associated transcriptional signatures in the brain ventricular system and cerebrospinal fluid development in full-term neonates.

Biology of sex differences May 25, 2025
BACKGROUND: The cerebrospinal fluid (CSF) is known to serve as a unique environment for neurodevelopment, with specific proteins secreted by epithelial cells of the choroid plexus (CP) playing crucial roles in cortical development and cell differenti...
Choroid Plexus Cerebrospinal Fluid Sex Characteristics Cerebral Ventricles Lateral Ventricles Male Transcriptome Magnetic Resonance Imaging Humans Brain Female Infant, Newborn
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A data-centric and interpretable EEG framework for depression severity grading using SHAP-based insights.

Journal of neuroengineering and rehabilitation May 25, 2025
BACKGROUND: Major Depressive Disorder is a leading cause of disability worldwide. An accurate assessment of depression severity is critical for diagnosis, treatment planning, and monitoring, yet current clinical tools are largely subjective, relying ...
Humans Machine Learning Algorithms Brain Female Adult Severity of Illness Index Male Depression Middle Aged Electroencephalography Depressive Disorder, Major
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SLIMBRAIN database: A multimodal image database of in vivo human brains for tumour detection.

Scientific data May 21, 2025
Hyperspectral imaging (HSI) and machine learning (ML) have been employed in the medical field for classifying highly infiltrative brain tumours. Although existing HSI databases of in vivo human brains are available, they present two main deficiencies...
Humans Machine Learning Brain Databases, Factual Brain Neoplasms Imaging, Three-Dimensional Hyperspectral Imaging
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Resting-State Functional MRI Reveals Altered Seed-Based Connectivity in Diabetic Osteoporosis Patients.

Clinical interventions in aging May 21, 2025
BACKGROUND: Diabetic osteoporosis (DOP) can cause abnormal brain neural activity, but its mechanism is still unclear. This study aims to further explore the abnormal functional connectivity between different brain regions based on the team's previous...
Osteocalcin Middle Aged Diabetes Mellitus, Type 2 Magnetic Resonance Imaging Humans Brain Osteoporosis Female Aged Male
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Virtual Electroencephalogram Acquisition: A Review on Electroencephalogram Generative Methods.

Sensors (Basel, Switzerland) May 18, 2025
Driven by the remarkable capabilities of machine learning, brain-computer interfaces (BCIs) are carving out an ever-expanding range of applications across a multitude of diverse fields. Notably, electroencephalogram (EEG) signals have risen to promin...
Brain-Computer Interfaces Algorithms Humans Brain Electroencephalography Neural Networks, Computer Signal Processing, Computer-Assisted Machine Learning
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