AIMC Topic: Case-Control Studies
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Morphological alterations of the thymus gland in individuals with schizophrenia.
Molecular psychiatry
Mar 4, 2025
Despite its critical function in the immune system and accumulating evidence of immunological abnormalities in schizophrenia, the thymus has long been overlooked. We aimed to investigate thymic morphological alterations and their corresponding hetero...
Bootstrap inference and machine learning reveal core differential plasma metabolic connectome signatures in major depressive disorder.
Journal of affective disorders
Mar 3, 2025
BACKGROUND: Major depressive disorder (MDD) involves molecular alterations and pathway dysregulation. Metabolic interconnections are crucial for normal functioning, yet current analysis focuses on individual pathways or biomarkers, overlooking intric...
The role of senescence-related genes in major depressive disorder: insights from machine learning and single cell analysis.
BMC psychiatry
Mar 3, 2025
BACKGROUND: Evidence indicates that patients with Major Depressive Disorder (MDD) exhibit a senescence phenotype or an increased susceptibility to premature senescence. However, the relationship between senescence-related genes (SRGs) and MDD remains...
Machine Learning-Based Identification of Novel Exosome-Derived Metabolic Biomarkers for the Diagnosis of Systemic Lupus Erythematosus and Differentiation of Renal Involvement.
Current medical science
Feb 28, 2025
OBJECTIVE: This study aims to investigate the exosome-derived metabolomics profiles in systemic lupus erythematosus (SLE), identify differential metabolites, and analyze their potential as diagnostic markers for SLE and lupus nephritis (LN).
Untargeted Lipidomic Biomarkers for Liver Cancer Diagnosis: A Tree-Based Machine Learning Model Enhanced by Explainable Artificial Intelligence.
Medicina (Kaunas, Lithuania)
Feb 26, 2025
: Liver cancer ranks among the leading causes of cancer-related mortality, necessitating the development of novel diagnostic methods. Deregulated lipid metabolism, a hallmark of hepatocarcinogenesis, offers compelling prospects for biomarker identifi...
Early detection of feline chronic kidney disease via 3-hydroxykynurenine and machine learning.
Scientific reports
Feb 26, 2025
Feline chronic kidney disease (CKD) is one of the most frequently encountered diseases in veterinary practice, and the leading cause of mortality in cats over five years of age. While diagnosing advanced CKD is straightforward, current routine tests ...
Serum Metabolomics Profiling Coupled with Machine Learning Identifies Potential Diagnostic and Prognostic Candidate Markers in Meningioma Using Raman Spectroscopy, ATR-FTIR, and LC-MS/MS.
Journal of proteome research
Feb 25, 2025
Meningioma, the most prevalent brain tumor, poses significant challenges due to its unclear transition from low-grade to aggressive forms, with limited knowledge about grade-specific markers. We have utilized vibrational spectroscopic techniques such...
Humans
Machine Learning
Prognosis
Female
Aged
Adult
Biomarkers, Tumor
Male
Meningioma
Meningeal Neoplasms
Metabolomics
Chromatography, Liquid
Liquid Chromatography-Mass Spectrometry
Middle Aged
Tandem Mass Spectrometry
Case-Control Studies
Spectrum Analysis, Raman
Spectroscopy, Fourier Transform Infrared
Cognitive performance classification of older patients using machine learning and electronic medical records.
Scientific reports
Feb 24, 2025
Dementia rates are projected to increase significantly by 2050, posing considerable challenges for healthcare systems worldwide. Developing efficient diagnostic tools is critical, and machine learning (ML) algorithms have shown potential for improvin...
Genetic association studies using disease liabilities from deep neural networks.
American journal of human genetics
Feb 21, 2025
The case-control study is a widely used method for investigating the genetic underpinnings of binary traits. However, long-term, prospective cohort studies often grapple with absent or evolving health-related outcomes. Here, we propose two methods, l...
Multi-cancer early detection based on serum surface-enhanced Raman spectroscopy with deep learning: a large-scale case-control study.
BMC medicine
Feb 21, 2025
BACKGROUND: Early detection of cancer can help patients with more effective treatments and result in better prognosis. Unfortunately, established cancer screening technologies are limited for use, especially for multi-cancer early detection. In this ...
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