AIMC Topic: Cells, Cultured

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Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways.

Environmental toxicology May 26, 2015
Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially ...
Chemotaxis, Leukocyte Diethylhexyl Phthalate Humans Interleukin-1beta Tumor Necrosis Factor-alpha NF-kappa B Benzhydryl Compounds Cell Migration Assays, Macrophage Middle Aged Cell Movement Cells, Cultured Estradiol Lipopolysaccharides Inflammation Macrophages Phenols Signal Transduction Cytokines Female
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Inter-species pathway perturbation prediction via data-driven detection of functional homology.

Bioinformatics (Oxford, England) Aug 22, 2014
MOTIVATION: Experiments in animal models are often conducted to infer how humans will respond to stimuli by assuming that the same biological pathways will be affected in both organisms. The limitations of this assumption were tested in the IMPROVER ...
Oligonucleotide Array Sequence Analysis Cells, Cultured Bronchi Cytokines Databases, Factual Phosphoproteins Animals Epithelial Cells Gene Expression Regulation Gene Expression Profiling Humans Models, Animal Phosphorylation Systems Biology Artificial Intelligence Species Specificity Translational Research, Biomedical Rats Software Signal Transduction Algorithms
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Annexin A2 Contributes to Release of Extracellular Vimentin in Response to Inflammation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology May 15, 2025
Vimentin, an abundant intracellular cytoskeletal protein, is secreted into the extracellular space, where it can amplify tissue destruction in inflammatory diseases. The mechanisms by which inflammation promotes the release of extracellular vimentin ...
Humans Cells, Cultured Inflammation Fibroblasts Periodontitis Interleukin-1beta Vimentin Gingiva Annexin A2
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Virtual white matter: a novel system for cross-dish neural interaction and modulation.

Journal of neural engineering May 14, 2025
. Biological neural networks (BNNs) are characterized by complex interregional connectivity, allowing for seamless communication between different brain regions.models traditionally consist of single-dish neural cultures that cannot recapitulate the ...
Humans Neural Networks, Computer White Matter Nerve Net Microelectrodes Electric Stimulation Cells, Cultured Animals Rats Neurons
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AI-guided laser purification of human iPSC-derived cardiomyocytes for next-generation cardiac cell manufacturing.

Communications biology May 13, 2025
Current methods for producing cardiomyocytes from human induced pluripotent stem cells (hiPSCs) using 2D monolayer differentiation are often hampered by batch-to-batch variability and inefficient purification processes. Here, we introduce CM-AI, a no...
Cell Separation Humans Induced Pluripotent Stem Cells Artificial Intelligence Cells, Cultured Cell Differentiation Myocytes, Cardiac Lasers
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[Evaluation of the efficacy of antifibrotic drugs on cell cultures in Salzmann's nodular degeneration].

Vestnik oftalmologii Jan 1, 2024
UNLABELLED: Excessive production of extracellular matrix is a key component in the pathogenesis of Salzmann's nodular degeneration (SND). studies of drugs that suppress excessive fibroblast activity may become crucial in developing pathogenetically ...
Cyclosporine Male Antifibrotic Agents Humans Myofibroblasts Cells, Cultured Cell Proliferation Fibroblasts Cornea Pyridones
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Scan-less machine-learning-enabled incoherent microscopy for minimally-invasive deep-brain imaging.

Optics express Jan 17, 2022
Deep-brain microscopy is strongly limited by the size of the imaging probe, both in terms of achievable resolution and potential trauma due to surgery. Here, we show that a segment of an ultra-thin multi-mode fiber (cannula) can replace the bulky mic...
Minimally Invasive Surgical Procedures Brain Microscopy, Fluorescence Neural Networks, Computer Green Fluorescent Proteins Neurons Animals Machine Learning Caenorhabditis elegans Neuroimaging Image Processing, Computer-Assisted Cells, Cultured Mice
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[Naringenin promotes osteogenic differentiation of BMSCs via SDF-1α/CXCR4 signaling axis].

Shanghai kou qiang yi xue = Shanghai journal of stomatology Dec 1, 2021
PURPOSE: To explore the influence of naringenin on osteogenic differentiation of bone mesenchymal stem cells(BMSCs), and the role of SDF-1α/CXCR4 signaling axis in the osteogenic differentiation by naringenin.
Bone Marrow Cells Flavanones Receptors, CXCR4 Cell Differentiation Osteogenesis Cells, Cultured Animals RNA, Messenger Rats Chemokine CXCL12
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Application of a deep learning-based image analysis and live-cell imaging system for quantifying adipogenic differentiation kinetics of adipose-derived stem/stromal cells.

Adipocyte Dec 1, 2021
Quantitative methods for assessing differentiative potency of adipose-derived stem/stromal cells may lead to improved clinical application of this multipotent stem cell, by advancing our understanding of specific processes such as adipogenic differen...
Adipogenesis Cell Differentiation Kinetics Stromal Cells Cells, Cultured Deep Learning Adipose Tissue
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Deep learning of gene relationships from single cell time-course expression data.

Briefings in bioinformatics Sep 2, 2021
Time-course gene-expression data have been widely used to infer regulatory and signaling relationships between genes. Most of the widely used methods for such analysis were developed for bulk expression data. Single cell RNA-Seq (scRNA-Seq) data offe...
Gene Regulatory Networks Mice Computational Biology Models, Genetic Time Factors Single-Cell Analysis RNA-Seq Epistasis, Genetic Humans Algorithms Cells, Cultured Animals Gene Expression Profiling Deep Learning
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