Over the past few decades, the number of health and 'omics-related data' generated and stored has grown exponentially. Patient information can be collected in real time and explored using various artificial intelligence (AI) tools in clinical trials;...
OBJECTIVES: Antidepressants are first-line treatments for major depressive disorder (MDD), but 40-60% of patients will not respond, hence, predicting response would be a major clinical advance. Machine learning algorithms hold promise to predict trea...
The process of bringing a drug to market involves innumerable decisions to refine a concept into a final product. The final product goes through extensive research and development to meet the target product profile and to obtain a product that is man...
Clinical trials require substantial effort and time to complete, and regulatory agencies may require two successful efficacy trials before approving a new drug. One way to improve the chance of follow-up success is to identify a subpopulation among w...
United European gastroenterology journal
Jun 7, 2021
BACKGROUND: Artificial intelligence (AI) using deep learning methods for polyp detection (CADe) and characterization (CADx) is on the verge of clinical application. CADe already implied its potential use in randomized controlled trials. Further effor...
Biochimica et biophysica acta. Reviews on cancer
May 31, 2021
Pharmaceutical agents in oncology currently have high attrition rates from early to late phase clinical trials. Recent advances in computational methods, notably causal artificial intelligence, and availability of rich clinico-genomic databases have ...
Cancer patients have a higher risk of cardiovascular disease (CVD) mortality than the general population. Low dose computed tomography (LDCT) for lung cancer screening offers an opportunity for simultaneous CVD risk estimation in at-risk patients. Ou...
In a time of rapid advances in science and technology, the opportunities for radiation oncology are undergoing transformational change. The linkage between and understanding of the physical dose and induced biological perturbations are opening entire...
INTRODUCTION: The SARS-CoV-2 pandemic has led to one of the most critical and boundless waves of publications in the history of modern science. The necessity to find and pursue relevant information and quantify its quality is broadly acknowledged. Mo...
There is a growing focus on making clinical trials more inclusive but the design of trial eligibility criteria remains challenging. Here we systematically evaluate the effect of different eligibility criteria on cancer trial populations and outcomes ...