AIMC Topic: Cohort Studies

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Mitochondrial mt12361A>G increased risk of metabolic dysfunction-associated steatotic liver disease among non-diabetes.

World journal of gastroenterology
BACKGROUND: Insulin resistance, lipotoxicity, and mitochondrial dysfunction contribute to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). Mitochondrial dysfunction impairs oxidative phosphorylation and increases ...

Machine learning-based models for advanced fibrosis in non-alcoholic steatohepatitis patients: A cohort study.

World journal of gastroenterology
BACKGROUND: The global prevalence of non-alcoholic steatohepatitis (NASH) and its associated risk of adverse outcomes, particularly in patients with advanced liver fibrosis, underscores the importance of early and accurate diagnosis.

Predicting amyloid beta accumulation in cognitively unimpaired older adults: Cognitive assessments provide no additional utility beyond demographic and genetic factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association
BACKGROUND: Integrating non-invasive measures to estimate abnormal amyloid beta accumulation (Aβ+) is key to developing a screening tool for preclinical Alzheimer's disease (AD). The predictive capability of standard neuropsychological tests in estim...

A deep-learning retinal aging biomarker for cognitive decline and incident dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association
INTRODUCTION: The utility of retinal photography-derived aging biomarkers for predicting cognitive decline remains under-explored.

Developing and validating a prediction tool for cerebral amyloid angiopathy neuropathological severity.

Alzheimer's & dementia : the journal of the Alzheimer's Association
INTRODUCTION: Cerebral amyloid angiopathy (CAA) is a cerebrovascular condition, the severity of which can only be determined post mortem. Here, we developed machine learning models, the Florey CAA Score (FCAAS), to predict CAA severity (none/mild/mod...

Deep Learning Model for Predicting Immunotherapy Response in Advanced Non-Small Cell Lung Cancer.

JAMA oncology
IMPORTANCE: Only a small fraction of patients with advanced non-small cell lung cancer (NSCLC) respond to immune checkpoint inhibitor (ICI) treatment. For optimal personalized NSCLC care, it is imperative to identify patients who are most likely to b...

Machine learning models for predicting postoperative peritoneal metastasis after hepatocellular carcinoma rupture: a multicenter cohort study in China.

The oncologist
BACKGROUND: Peritoneal metastasis (PM) after the rupture of hepatocellular carcinoma (HCC) is a critical issue that negatively affects patient prognosis. Machine learning models have shown great potential in predicting clinical outcomes; however, the...

Improving precision instrument cleaning with a quality control module: implementation and outcomes.

Frontiers in public health
OBJECTIVE: To evaluate the effectiveness of a cleaning quality control module integrated into a hospital's Disinfection Supply Center (DSC) for improving the cleaning quality of precision surgical instruments.

Diagnosis Osteoporosis Risk: Using Machine Learning Algorithms Among Fasa Adults Cohort Study (FACS).

Endocrinology, diabetes & metabolism
INTRODUCTION: In Iran, the assessment of osteoporosis through tools like dual-energy X-ray absorptiometry poses significant challenges due to their high costs and limited availability, particularly in small cities and rural areas. Our objective was t...