AIMC Topic: Computational Biology

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A transformer architecture based on BERT and 2D convolutional neural network to identify DNA enhancers from sequence information.

Briefings in bioinformatics
Recently, language representation models have drawn a lot of attention in the natural language processing field due to their remarkable results. Among them, bidirectional encoder representations from transformers (BERT) has proven to be a simple, yet...

Why can deep convolutional neural networks improve protein fold recognition? A visual explanation by interpretation.

Briefings in bioinformatics
As an essential task in protein structure and function prediction, protein fold recognition has attracted increasing attention. The majority of the existing machine learning-based protein fold recognition approaches strongly rely on handcrafted featu...

Accurate prediction of multi-label protein subcellular localization through multi-view feature learning with RBRL classifier.

Briefings in bioinformatics
Multi-label proteins can participate in carrier transportation, enzyme catalysis, hormone regulation and other life activities. Meanwhile, they play a key role in the fields of biopharmaceuticals, gene and cell therapy. This article proposes a predic...

Anticancer peptides prediction with deep representation learning features.

Briefings in bioinformatics
Anticancer peptides constitute one of the most promising therapeutic agents for combating common human cancers. Using wet experiments to verify whether a peptide displays anticancer characteristics is time-consuming and costly. Hence, in this study, ...

XGSEA: CROSS-species gene set enrichment analysis via domain adaptation.

Briefings in bioinformatics
MOTIVATION: Gene set enrichment analysis (GSEA) has been widely used to identify gene sets with statistically significant difference between cases and controls against a large gene set. GSEA needs both phenotype labels and expression of genes. Howeve...

MSIsensor-ct: microsatellite instability detection using cfDNA sequencing data.

Briefings in bioinformatics
MOTIVATION: Microsatellite instability (MSI) is a promising biomarker for cancer prognosis and chemosensitivity. Techniques are rapidly evolving for the detection of MSI from tumor-normal paired or tumor-only sequencing data. However, tumor tissues a...

GAERF: predicting lncRNA-disease associations by graph auto-encoder and random forest.

Briefings in bioinformatics
Predicting disease-related long non-coding RNAs (lncRNAs) is beneficial to finding of new biomarkers for prevention, diagnosis and treatment of complex human diseases. In this paper, we proposed a machine learning techniques-based classification appr...

Towards deep phenotyping pregnancy: a systematic review on artificial intelligence and machine learning methods to improve pregnancy outcomes.

Briefings in bioinformatics
OBJECTIVE: Development of novel informatics methods focused on improving pregnancy outcomes remains an active area of research. The purpose of this study is to systematically review the ways that artificial intelligence (AI) and machine learning (ML)...