AIMC Topic: Drug Liberation
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Physicochemical characterization of an arabinoxylan-rich fraction from brewers' spent grain and its application as a release matrix for caffeine.
Food research international (Ottawa, Ont.)
Sep 18, 2018
The brewers' spent grain is a by-product generated during brewery process and is a potential source for arabinoxylans (AX) extraction. In the present work, the extraction and characterization of an arabinoxylan-rich fraction from brewers' spent grain...
Comparison of response surface methodology and artificial neural network to optimize novel ophthalmic flexible nano-liposomes: Characterization, evaluation, in vivo pharmacokinetics and molecular dynamics simulation.
Colloids and surfaces. B, Biointerfaces
Aug 23, 2018
To improve the topical delivery of pilocarpine hydrochloride (PN) to treat glaucoma, flexible nano-liposomes containing PN (PN-FLs) were prepared, optimized and characterized. Artificial neural network (ANN) and response surface methodology (RSM) wer...
Robotic microplate voltammetry for real-time hydrogel drug release testing.
Analytica chimica acta
Aug 20, 2018
Robotic square wave voltammetry (SVW) in 24-well microtiter plates has been developed as a reliable non-manual procedure for quantifying drug release from pharmaceutical hydrogels. The assay was established using 1% agarose disks containing Paracetam...
Cell-Like Micromotors.
Accounts of chemical research
Aug 3, 2018
In the past decade, versatile micro- and nanosized machines have emerged as active agents for large-scale detoxification, sensing, microfabrication, and many other promising applications. Micromachines have also been envisioned as the next advancemen...
Statistical moments in modelling of swelling, erosion and drug release of hydrophilic matrix-tablets.
International journal of pharmaceutics
Feb 1, 2018
Statistical moments were evaluated as suitable parameters for describing swelling and erosion processes (along with drug release) in hydrophilic controlled release matrix tablets. The effect of four independent formulation variables, corresponding to...
Enhanced antitumor efficacy of doxorubicin-encapsulated halloysite nanotubes.
International journal of nanomedicine
Dec 19, 2017
To improve the antitumor efficacy of doxorubicin (DOX) and provide novel clinical treatment of gastric cancer, halloysite nanotubes (HNTs) loaded with DOX were encapsulated by soybean phospholipid (LIP) and the formed HNTs/DOX/LIP was systematically ...
Medical capsule robots: A renaissance for diagnostics, drug delivery and surgical treatment.
Journal of controlled release : official journal of the Controlled Release Society
Jul 8, 2017
The advancements in electronics and the progress in nanotechnology have resulted in path breaking development that will transform the way diagnosis and treatment are carried out currently. This development is Medical Capsule Robots, which has emerged...
Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.
Journal of colloid and interface science
Dec 31, 2016
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Humans
Animals
Nanoparticles
Cell Line
Cell Survival
Drug Carriers
Hydrophobic and Hydrophilic Interactions
Polypropylenes
Surface Properties
Solubility
Fumarates
Ibuprofen
Anti-Inflammatory Agents, Non-Steroidal
Drug Liberation
Anhydrides
Micelles
Rabbits
Prodrugs
Hydrogen-Ion Concentration
HeLa Cells
Polyethylene Glycols
Hydrolysis
Graphene oxide as a nanocarrier for controlled release and targeted delivery of an anticancer active agent, chlorogenic acid.
Materials science & engineering. C, Materials for biological applications
Dec 5, 2016
We have synthesized graphene oxide using improved Hummer's method in order to explore the potential use of the resulting graphene oxide as a nanocarrier for an active anticancer agent, chlorogenic acid (CA). The synthesized graphene oxide and chlorog...
Delayed-Action Preparations
Hydrogen Bonding
Microscopy, Electron, Transmission
Thermogravimetry
Drug Liberation
HeLa Cells
Graphite
Chlorogenic Acid
X-Ray Diffraction
Antineoplastic Agents
A549 Cells
Spectrum Analysis, Raman
Oxides
Spectroscopy, Fourier Transform Infrared
Hydrogen-Ion Concentration
Hep G2 Cells
Nanocomposites
Cell Survival
Humans
Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen.
Pharmaceutical development and technology
Dec 20, 2015
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs.
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